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Parkinson's Disease - U.S. Department of Veterans Affairs

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Last Updated: 27 April 2022

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Predictive Modeling of Alzheimer's and Parkinson's Disease Using Metabolomic and Lipidomic Profiles from Cerebrospinal Fluid.

Several statistical issues confronting metabolomic studies in which the number of measured metabolites far outnumbers sample size are discussed. We found significant differences in the metabolome between PD and controls, as well as between PD and AD, with less separation between AD and controls. Vitamin E and urea cycle metabolism pathways are associated with PD, according to untargeted and targeted metabolite profiles, and AD is linked to PD, while aspartate/asparagine and c21-steroid hormone biosynthesis pathways are associated with AD.

Source link: https://doi.org/10.3390/metabo12040277


Discussion of Research Priorities for Gait Disorders in Parkinson's Disease.

Development of Parkinson's disease and balance abnormalities are common in Parkinson's disease and are among the motor signs that are most disabling and refractory to dopaminergic or other medications, including deep brain stimulation.

Source link: https://doi.org/10.1002/mds.28883


Regional cerebral cholinergic nerve terminal integrity and cardinal motor features in Parkinson's disease.

Changes in some cardinal motor dysfunctions in Parkinson's disease are attributed to physiological changes in the pathophysiology of some cardinal motor impairments in Parkinson's disease. Model-selected regions were identified by regression with motor domain scores for model-selected areas, followed by a confounder review for the effects of age of onset, duration of motor disease, and levodopa equivalent dose were administered. Among seven model-derived regions associated with postural instability and gait difficulties, three of the three most prominent domains for confounder variable analysis remained significant: medial geniculate nucleus, lateral geniculate nucleus, and entorhinal cortex. The medial geniculate nucleus, entorhinal cortex, and globus pallidus pars interna were all shown by a sub-analysis of non-episodic postural variability and gait difficulties scores, as well as gait difficulties. Among the six tremor domain model-selected regions, two regions retained their significance in confounder variable analysis: cerebellar vermis section of lobule VIIIb and the putamen. paraphrasergic pathways' more granular signalling mechanisms with less reliance from cholinergic pathways are likely to be non-specific regional cholinergic nerve terminal affiliations with rigidity scores.

Source link: https://doi.org/10.1093/braincomms/fcab109


Does visuospatial motion perception correlate with coexisting movement disorders in Parkinson's disease?

The latest results revealed that PD patients had a poor sense of self-motion in the vestibular domain. Moving retinal picture or self-motion in space promotes the sense of self-motion. When subjects were moved en bloc using a moving platform, one's linear motion perception was determined by one's linear motion perception. The accuracy of perceived motion direction was determined from the responses fitted to the psychometric function curves, allowing the subjects to determine how accurately and precisely the subjects can distinguish rightward versus leftward motion. Using the Activities-Specific Balance Component Scale, we also linked heading estimation with the number of falls and subjective assessment of balance using the Activities-Specific Balance Component Scale. Differences in the clinical findings that relate to visual versus vestibular heading perception mean that the two heading perception processes have different mechanistic underpinnings. Visual representation can be used for balance therapy in PD patients, according to the correlation between discordance between vestibular and visual heading perceptions with disease severity and duration.

Source link: https://doi.org/10.1007/s00415-021-10804-2

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions