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Parkinson's Disease - Springer Nature

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Last Updated: 27 April 2022

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Associations of sleep disorders with cerebrospinal fluid α-synuclein in prodromal and early Parkinson’s disease

In healthy controls, and patients with prodromal and early Parkinson's disease, we intend to investigate sleep disorders in cerebrospinal fluid synuclein. Multiple linear regression models and linear mixed-effects models were used to investigate sleep disorders' correlations with baseline and longitudinal CSFsyn. Multiple linear regression models were used to analyze correlations between sleep disorder change rates and CSF syn. The connection between high hopes and lower CSF syn higher survived Bonferroni correction. When inactive-sitting in public places showed reduced CSF -syn, CSFs with daytime sleepiness decreased. In addition, increased chances of daytime sleepiness when sitting and reading contributed to a larger decrease in CSF -syn in HCs. Conclusions Sleep disorders were correlated with reduced CSF -syn's decreased CSF. Sleep control can be helpful in disease surveillance and preventing the development of syn pathology.

Source link: https://doi.org/10.1007/s00415-021-10812-2


Effect of onset age on the levodopa threshold dosage for dyskinesia in Parkinson's disease

Introduction With the levodopa threshold effect on dyskinesia found, a threshold dose of levodopa was found in the general Parkinson's disease population. Although early-onset PD and late-onset PD are both similar in their pathogenesis and clinical manifestations, a threshold dose for personalized care remains undetermined. Both physicians and LOPD patients were randomized to the recommended dosage of levodopa in EOPD and LOPD patients. To determine the levodopa threshold dosages for dyskinesia, the receiver operating characteristic curve was used. 6. 2 percent in the EOPD group and 24. 1% in the LOPD group, respectively. Optimo daily dose and levodopa response for EOPD patients and their levodopa daily dose, short levodopa treatment duration, low body mass, use of entacapone, and a large Hoehn–Yahr stage in off state for LOPD patients are among the dyskinesia risk factors identified for dyskinesia. Conclusion Using LOPD patients, EOPD patients had lower levodopa threshold dosages than LOPD patients.

Source link: https://doi.org/10.1007/s10072-021-05694-1


The impact of poor medication knowledge on health-related quality of life in people with Parkinson’s disease: a mediation analysis

Purpose This study was conducted to see whether inadequate medication knowledge as one component of health literacy could lead to poorer health-related quality of life in people with Parkinson's disease. Conclusions Overall, 43. 5% patients demonstrated deficiencies in at least one of the four knowledge items, including elevated age, number of medications per day, and depression severity, as well as impaired cognitive function, motor coordination, and lower education levels were all related to higher education. We discovered that medication knowledge had a significant effect on physical stability, social functioning, career limitations due to physical challenges, and emotional difficulties as a result of emotional disorders. The relationship between knowledge and SF-36 domains was fully mediated by Beck's Depression Inventory but not by Montreal Cognitive Assessment. Patients who expressed surprise with their medications did not necessarily have cognitive impairments; however, depressive symptoms may have arisen.

Source link: https://doi.org/10.1007/s11136-021-03024-8


Neuroinflammation in Parkinson's disease: a meta-analysis of PET imaging studies

However, brain imaging has not arrived to a unanimous conclusion that neuroinflammation is involved in Parkinson's disease pathogenesis. We systematically searched literature databases for case-control studies that used positron emission tomography to detect neuroinflammation in PD patients compared to healthy controls. When using 1st-generation ligands, PD patients' TSPO levels in midbrain, putamen, anterior cingulate, posterior cingulate, posterior cingulate, thalamus, striatum, thalamus, striatum, occipital, cortex, cerebellum, and caudate increased, compared to HC. As 2nd-generation ligands were used, TSPO levels were elevated in the midbrain of PD patients.

Source link: https://doi.org/10.1007/s00415-021-10877-z


Quantitative assessment of the effect of FGF20 rs1721100 and rs12720208 variant on the risk of sporadic Parkinson’s disease: a meta-analysis

Objectives While many studies have looked into the correlations between fibroblast growth factor 20 rs1721100 and rs12720208 polymorphisms and susceptibility to Parkinson's disease, Parkinson's disease, several research has been published, but the results are conflicting. According to our latest meta-analysis, there was a direct correlation between FGF20 rs1721100 and rs12720208 polymorphisms as a result of sporadic PD. The association of the FGF20 rs1721100 and rs12720208 polymorphisms, as well as sporadic PD risk were estimated using mixed odds ratios and 95% confidence intervals. Results Our results revealed that the FGF20 rs1721100 G allele frequency and genotype distribution did not differ between PD patients and controls, as shown by our analysis. In the same way, the FGF20 rs12720208 T allele frequency and genotype distribution did not vary significantly between the two groups. The same findings were obtained by a subgroup analysis of Asian and Caucasian populations. Conclusions The results of this meta-analysis revealed that neither the rs1721100 C/G nor the rs12720208 C/T variants were associated with sporadic PD susceptibility.

Source link: https://doi.org/10.1007/s10072-021-05754-6


Brain network topology and future development of freezing of gait in Parkinson’s disease: a longitudinal study

Symptoms of Parkinson's disease Background Freezing of gait is a common disabling gait disorder in Parkinson's disease. Methods We recruited 20 patients with PD who did not develop FOG during the follow-up period, 20 patients with PD who did not develop FOG during the follow-up period, and 20 healthy control subjects. No abnormalities were found in the PD-FOGt and PD-FOGn's global topological profiles of functional brain networks at baseline. Patients with PD-FOGn patients also showed reduced centrality in the left middle frontal gyrus, according to another study. The PD-FOGt group had the lowest nodal centrality values in the frontal cortex and visual cortex, as well as the highest nodal centrality values in the cerebellum among the three groups, although there were no significant differences between the two groups compared to PD-FOGn patients.

Source link: https://doi.org/10.1007/s00415-021-10817-x


Abnormal connectivity model of raphe nuclei with sensory-associated cortex in Parkinson’s disease with chronic pain

Background and Objective The following information and goals The presence of persistent pain in Parkinson's disease has been reported, and raphe nuclei may have been implicated. We looked at the functional connectivity pattern of raphe nuclei in Parkinson's disease with chronic pain in order to determine its potential pathophysiology. Methods Fifteen PDP patients with no pain suffered from pain for more than three months, sixteen Parkinson's disease patients without pain, and eighteen matched normal health controls were recruited. PDP demonstrated greater functional connectivity between raphe nuclei and pain-related brain regions, including parietal lobe, cingulum cortex, and prefrontal cortex, according to reports, which were significantly higher correlated with KPPs independent of the clinical variables. Conclusions Abnormal functional connectivity model of raphe nuclei may be partially responsible for the PD's pain pathophysiological pathway.

Source link: https://doi.org/10.1007/s10072-022-05864-9


Prevalence and Cost of Care for Parkinson’s Disease in Luxembourg: An Analysis of National Healthcare Insurance Data

It's current and expensive treatment of PD in Luxembourg are uncertain. Objective The aim of this survey was to determine the incidence of PD in Luxembourg and the cost of treatment for PD to the national healthcare insurance industry based on routinely obtained healthcare records. People with PD were classified based on drug reimbursement profiles and medication use histories. According to a comparative review of the healthcare services used by people with PD in comparison to an age- and sex-matched control group, the cost of care was estimated. Results in 2016 We found a PD prevalence of 928 per 100,000 people aged 50 years and older in men and women, who were older than in women. In 2016, the total cost of care for PD was estimated at €22,673 per patient per year, with the highest costs being associated with long-term care.

Source link: https://doi.org/10.1007/s41669-021-00321-3


Interval timing and midfrontal delta oscillations are impaired in Parkinson’s disease patients with freezing of gait

One of the causes of abnormal gait patterns in PD patients may be a strong correlation between gait abnormalities and cognitive impairment, according to new studies. However, the pathophysiological causes of cognitive impairment in PD patients with gait disorders are uncertain. We collected scalp electroencephalography data during a 7-s interval timing experiment to explore the possible cause of cognitive impairment in PD patients with and without freezing of gait, as well as control subjects. According to PDFOG- and control groups, the PDFOG+ group had the lowest maximum response density at around 7 s compared to PDFOG- and control groups, and this response density peak was found to be closely related to gait abnormalities as determined by FOG ratings. In PDFOG+, these results show that abnormal midfrontal activity in PDFOG + is related to cognitive impairment and affect cognitive dysfunction, as well as the mechanistic association between cognitive and gait functions.

Source link: https://doi.org/10.1007/s00415-021-10843-9


Metabolic correlates of olfactory dysfunction in COVID-19 and Parkinson’s disease (PD) do not overlap

We wanted to investigate the neurobiological causes of isolated persistent hyposmia after mild-to-moderate COVID-19 and to compare them with the metabolic signature of hyposmia in drug-nave PD patients. Patients with hyposmia were also compared to eighty-two drug-nave PD patients with hyposmia. In patients' subgroups, multiple regression analysis was used to determine correlations between olfactory test scores and brain metabolism. Patients exhibited significant hypogyria in the bilateral gyrus rectus and orbitofrontal cortex with respect to COVID-hyposmia, frontal gyri, medial/middle frontal gyri, and right insula with respect to PD-hyposmia, according to COVID-hyposmia. Patients with respect to COVID-hyposmia hypometabolism in inferior/middle occipital gyri and cuneus bilaterally. In COVID-hyposmia patients, and with bilateral cuneus/precuneus and left lateral occipital cortex in PD-hyposmia patients, blood glucose was directly related to metabolism in bilateral rectus and medial frontal gyri and in the right middle temporal and anterior cingulate gyri and left lateral occipital cortex and left lateral occipital cortex in gy.

Source link: https://doi.org/10.1007/s00259-021-05666-9

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions