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Parkinson's Disease - Astrophysics Data System

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Last Updated: 27 April 2022

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Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson's disease

The transcriptional repressor PARIS, which was largely responsible for dopamine neuron survival by increasing PGC-1–dependent mitochondrial biogenesis, is of direct relevance to dopamine neuron survival. Notably, the knockout of PARIS reduces dopaminergic neurodegeneration in mouse models, meaning that interventions that prevent dopaminergic accumulation of PARIS may have therapeutic potential in PD. CYLD is a negative regulator of dopamine neuron survival, and inhibition of CYLD may be helpful in PD by lowering PARIS levels and encouraging mitochondrial biogenesis.

Source link: https://ui.adsabs.harvard.edu/abs/2022SciA....8H1824P/abstract


Early downregulation of hsa-miR-144-3p in serum from drug-naïve Parkinson's disease patients

Advanced age is one of Parkinson's Disease's most common risk factors. However, the connection between microRNA remodelling and Parkinson's Disease has yet to be fully understood. Therefore, the main purpose of this research is to determine the relevance of microRNAs as biomarkers of Parkinson's Disease within the ageing context. We used Next Generation Sequencing to analyze serum microRNAs from samples of Parkinson's Disease and healthy ageing as well as Parkinson's Disease patients, age-matched with Parkinson's Disease patients. Potential microRNA candidates markers, which were derived from the combination of differential expression and network analysis, were further validated in an independent cohort that included both drug-nave and advanced Parkinson's Disease patients and healthy siblings of Parkinson's Disease patients, who are at a higher risk of developing the disease. Early Parkinson's Disease and Ageing patients have consistently poorer hsa-miR-144-3p, although we did not find evidence that microRNAs co-regulated in Parkinson's Disease and ageing, we do know that hsa-miR-144-3p is consistently down-regulated.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..12.1330Z/abstract


Comparison of Montreal cognitive assessment and Mattis dementia rating scale in the preoperative evaluation of subthalamic stimulation in Parkinson's disease

Introduction The preoperative evaluation of Parkinson's Disease patients for subthalamic nucleus deep brain stimulation includes the examination of the patient's neuropsychological condition as well as brain stimulation. The Montreal psychological examination has also been found to be a fast, time-sparing device with high diagnostic reliability in PD. We investigate the use of the MoCA as a preoperative screening measure for PD patients receiving bilateral STN-DBS. In PD patients undergoing STN-DBS, the MoCA, but not the MDRS, has documented significant postoperative cognitive decline. Patients with a MoCA score of 23 points had a dramatic decrease in quality of life after DBS surgery, relative to patients with more than 20 points. Conclusion This research identifies the MoCA as an alternative measure in the preoperative evaluation of PD patients for the detection of neuropsychological abnormalities and prediction of postoperative quality of life.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1765314G/abstract


Factors affecting postural instability after more than one-year bilateral subthalamic stimulation in Parkinson's disease: A cross-sectional study

Background: Parkinson's disease is multifactorial, and symptoms related to subthalamic stimulation vary in different studies. Objective We wanted to investigate the combination of predictive clinical causes of balance impairment in Parkinson's disease patients treated with bilateral subthalamic stimulation for at least one year. Methods We recruited 24 patients with Parkinson's disease who were treated with bilateral subthalamic stimulation and 24 healthy controls. With four experiments, we investigated four stimulation conditions: eye open and closed, stance on a concrete ground with eyes open and closed, and closed stance on a foam platform with eyes open and closed. In each plane of the three dimensions, the distance between the subthalamic motor center and the stimulation center was calculated individually. We compared the sway values in the four stimulation conditions in the patient group to the control values.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1764114K/abstract


Changes in elbow flexion EMG morphology during adjustment of deep brain stimulator in advanced Parkinson's disease

Objective Deep brain stimulation is a safe therapy for motor symptoms of advanced Parkinson's disease. For 13 patients with advanced PD and were receiving DBS, Methods Muscle activation tests were performed. The measured EMG signals were analyzed with parameters that characterize the EMG signal morphology, and the results were compared to the adjustment's clinical findings. The most noticeable signal recurrence rate was affected by the DBS adjustment, which raised the signal recurrence rate the most. With optimized stimulation settings, the patients' Unified Parkinson's Disease Rating Scale motor part score decreased by 35% on average, relative to turning the device off. However, the changes in UPRDS-III arm tremor and rigidity scores did not change significantly in any settings relative to the optimal stimulation settings. Conclusion The adjustment of DBS therapy alters the muscle activation patterns in PD patients.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1766936R/abstract


Striatal origin of the pathologic beta oscillations in Parkinson's disease

Enhanced oscillations at beta frequencies are a hallmark neural pathology in Parkinson's disease patients's basal ganglia and cortex. Population oscillations in the beta frequency range are caused by the interaction of the synaptic GABAa currents with the intrinsic membrane M-current. We show experimentally that direct infusion of the cholinergic agonist carbachol into the striatum but not into the awakened cortex of the awake, normal rodent, results in significant beta frequency oscillations in the local field potential.

Source link: https://ui.adsabs.harvard.edu/abs/2011PNAS..10811620M/abstract


Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain

Parkinson disease is a common cause of Parkinson's disease owing to mutations in the gene encoding for leucine-rich-repeat kinase 2. We use the results to investigate two conflicting models of Roc oligomerization by quantitatively demonstrating its GTPase activity in both monomeric and dimeric states. Both GTP binding and GTPase activity of Roc are affected by a PD-causing mutation, according to the researchers.

Source link: https://ui.adsabs.harvard.edu/abs/2014PNAS..111.4055L/abstract


Alternate fluency in Parkinson's disease: A machine learning analysis

The aim of this research was to see if patients with Parkinson's Disease had changes in their level of participation in extra-dimensional shift by implementing a novel analysis technique, using the latest alternate phonemic/semantic fluency test. Methods We used machine learning to produce high-accuracy classification of PD patients with high and low scores in the alternate fluency test. The most accurate cut-off of a decision rule based on this test gave a rate of 86. 96 percent. Following the removal of the semantic fluency test from the system, the phonemic fluency test was the parameter that most accurately contributed to the classification. Conclusion We found that ML analysis of semantic and phonemic verbal fluency could be used to identify simple rules with high precision and excellent out of sample generalization, allowing the detection of executive deficits in patients with PD.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1765803F/abstract


Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease

Autosomal recessive early-onset Parkinson disease is the product of autosomal recessive early-onset Parkinson disease. These mice also experience age-dependent bilateral degeneration at the locus ceruleus nucleus and mild motor behavior deficits at age-old time points. Therefore, the DJ1-C57 mouse provides a platform to investigate neurodegeneration's pre- and postnatal processes. We discover candidate gene editing genes that segregate with the phenotype, providing potentially useful information into how certain genes can influence mouse genomics, which can lead to mutations of DJ-1-related degeneration.

Source link: https://ui.adsabs.harvard.edu/abs/2012PNAS..10915918R/abstract


Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease

Here, we have evidence that P7C3 also protects mature neurons in brain regions outside of the hippocampus. According to Dose-response reports, the P7C3 derivative P7C3A20 blocks cell death with even greater potency and effectiveness, which correlates the relative potency and effectiveness of these agents in blocking apoptosis of newborn neural precursor cells of the dentate gyrus. Both P7C3 and P7C3A20 block 1-methyl-4-pyridinium-mediated neuro death in Caenorhabditis elegans and C. elegans' mobility following MPP + exposure. In vitro testing of P7C3 analogs for proneurogenic activity in the hippocampus may also prove a reliable way of predicting neuroprotective activity in the hippocampus. P7C3 and P7C3A20's physical chemistry scaffolding, we suggest, provides a basis for developing and marketing pharmacologic agents for the care of patients with PD.

Source link: https://ui.adsabs.harvard.edu/abs/2012PNAS..10917010D/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions