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Fresh yeast could prevent both beriberi and pellagra, respectively, but the u2019 antipolyneuritis factor is thermolabile, in particular, although the antipellagra factor is heat-soluble, implying that there are at least two water-soluble vitamins. Vitamin B 2 was ultimately discovered to be a complex of several chemically unrelated heat-stable causes, including niacin, biotin, and pantothenic acid, although vitamin B 1 was initially determined to be a single chemical compound. Morbid pellagra: recognition that niacin is a vitamin in the early twentieth century resulted from attempts to diagnose and treat a common human disease. In comparison, the discovery that biotin and pantothenic acid are vitamins came a few years later as a result of research into microbial growth factors. Symptomatic nutritional deficiencies of biotin and pantothenic acid were, and continue to be, extremely rare.
Source link: https://doi.org/10.1159/000343115
Excreted chyme was cultured for more than five days, as well as niacin, and pantothenic acid levels in the food and chyme samples were determined microbiologically. The food used changed intestinal bioavailability of niacin and pantothenic acid. Wholemeal bread had a statistically significant negative effect on the apparent dietary niacin availability relative to other foods, which was averaged by 40%. The pantothenic acid digestibility results were higher than those observed with niacin, according to food-related differences. The digestibility values of pantothenic acid from wheat, potatoes, and meat meals varied between 65% and 81%, indicating the order wheat diet > pork diet > beef diet, although statistically insignificant. Pantothenic acid from the coarse wholemeal bread diet was less digestible by more than 30%.
Source link: https://doi.org/10.1024/0300-98220.127.116.11
For the samples collected from plants, a good correlation of the MA and the SIDA of total PA was found, but for the animal origin products, higher percentages were determined by MA than by SIDA. On the one hand, the findings of santetheinase and phosphatase treatments, as well as papain and diastase on the other, has been shown that MA is able to determine a significant amount of bound PA. In addition, the results show that microbial enzymes were able to cleave PA conjugates more efficiently than pantetheinase and phosphatase treatment.
Source link: https://doi.org/10.1024/0300-9818.104.22.168
Abstract: Acoustic and viscometric measurements are increasingly being used to investigate pure components's structure as well as the presence, and order of intermolecular interactions among constituents in solution. The following information was obtained: The tenacity, viscosity, and ultrasonic velocity of aqueous D-Pantothenic acid hemi-calcium salt at 298. 15K and 300. 15K were measured. Acoustic measurements are useful in determining molecular interactions in binary liquid mixtures.
Source link: https://doi.org/10.22214/ijraset.2022.41366
The XRD pattern indicated that HP'u03b2-CD/PA NFs were achieved due to the construction of a new amorphous structure, and the appearance of a new amorphous structure. The phase solubility test demonstrated increased solubility of PA as a result of integration integration; in addition, the stoichiometry of HP-u03b2-CD/PA was determined to be 1:1. The release of PA from HPu03b2-CD/PA NFs delayed Escherichia coli and Staphylococcus aureus bacteria colonization to a great extent, as shown by the antibacterial activity tests. 93. 1% indicates that the cell viability of HCT-116 cells treated with 100 ml of HP/PA NFs was at 97. 5 u00b1 NFs, not 91 percent. Due to the solubility increase, HP's CD/PA NFs had increased anticancer activity than pure PA and HP (u03b2-CD).
Source link: https://doi.org/10.1177/15280837221082032
In juvenile blunt snout megalobram amblycephala, this study was to clarify the effects of dietary pantothenic acid on growth, lipid metabolism, and antioxidant status in juvenile blunt snout bream Megalobrame amblycephala. For eight weeks, fish were fed with four experimental diets containing two lipid levels and two PA supplementation levels. The muscle's EPA, DHA, and EPA + DHA content of the muscle was found in a strong negative relationship between dietary lipid and PA supplementation on EPA, DHA, and EPA + DHA content. With an dietary lipid level rise, saturated fatty acid and polyunsaturated fatty acid levels in the liver were noticeably raised, while liver monounsaturated fatty acid were significantly reduced. Muscle SFA, DHA, and EPA + DHA levels were all significantly reduced when the dietary fat content increased.
Source link: https://doi.org/10.1155/2022/4229905
The decrease in pantothenic acid uptake in all diabetic animals occurred when hearts were perfused with 1. 2 m palmitate or 1. 2 m palmitate with 11 mM glucose. A dramatic rise in pantothenic acid uptake was observed when insulin was added to the perfusion medium of spontaneously diabetic rats perfused with palmitate and glucose. Insulin had no effect on pantothenic acid uptake in hearts from spontaneously diabetic rats perfused with palmitate alone, according to insulin. These results show that insulin, in the presence of glucose, may elevate pantothenic acid uptake in diabetic rats.
Source link: https://doi.org/10.2337/diab.37.10.1335
CoA is also the only source of the phosphopantetheine prosthetic group for enzymes shuttle intermediates between the active enzymes involved in fatty acid, nonribosomal peptide, and polyketide synthesis. Pantothenate can be synthesized de novo and/or transported into the cell by a pantothenatepermease. CoA is made in five enzymatic steps, beginning with the phosphorylation of pantothenate to phosphopantothenate catalyzed by pantothenate kinase, the coaA gene product. The production of phosphopantothenate by pantothenate kinase in some bacteria is the fastest restricted step in the biosynthetic pathway, with rate limits and most tightly controlled steps.
Source link: https://doi.org/10.1128/ecosalplus.22.214.171.124
Toxoplasma gondii is a common food pathogen and neglected parasitic disease that causes eye disease, birth defects, and fetal abortion, and is responsible for AIDS-related opportunistic disease. We investigated pantothenic acid biosynthesis in T. gondii in this research. The complete repertoire of enzymes for pantothenate manufacturing and subsequent metabolism to coenzyme A has been found and expressed in T. gondii. A panel of inhibitors designed to inhibit Mycobacterium tuberculosis pantothenate synthetase growth was tested and found to have a variety of values for T. gondii inhibition.
Source link: https://doi.org/10.1128/aac.02640-14
ABSTRACT The growth and expansion of the human malaria parasite Plasmodium falciparum are dependent on the parasite's ability to obtain essential nutrients. A series of pantothenic acid analogs that maintain the 2,4-dihydroxy-3,3-dimethylbutyramide core of pantothenic acid but differ in structure from one another and pantothenic acid's substitute component attached to the amide nitrogen were synthesized using a simple single-step synthetic route in this study. In vitro, eight of the ten closest analogs tested inhibited the proliferation of intraerythrocytic P. falciparum parasites, doing so at 50% inhibitory concentrations between 15 and 200 u03bcM.
Source link: https://doi.org/10.1128/aac.49.11.4649-4657.2005
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