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PKD - U.S. Department of Veterans Affairs

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Last Updated: 02 January 2022

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Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR PROTEIN KINASE D (PKD).

Our outcomes reveal that stimulation of digestive epithelial IEC-18 cells with the G protein-coupled receptor agonist angiotensin II, a potent mitogen for these cells, generated rapid translocation of YAP from the core to the cytoplasm and a concomitant rise in YAP phosphorylation at Ser and Ser Angiotensin II generated YAP phosphorylation and cytoplasmic buildup in a dose-dependent way. In yap, turn and taz are essential for the stimulation of the proliferative response of intestinal tract epithelial cells to GPCR agonists that act using PKD. The exploration of interaction between YAP and PKD paths determines unique cross-talk in signal transduction and shows, for the very first time, that the PKDs feed into the YAP pathway.

Source link: https://doi.org/10.1074/jbc.M115.711275


PKD signaling and pancreatitis.

Severe pancreatitis is a severe clinical condition without current therapies routed to the molecular pathogenesis of the disorder. An unique serine/threonine protein kinase D family has become key participants in signal transduction, and this family is significantly being implicated in the regulation of several cellular functions and diseases.

Source link: https://doi.org/10.1007/s00535-016-1175-3

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions