Pkd - Europe PMC

Potential Therapeutic Effects of Long-Term Stem Cell Administration: Impact on the Gene Profile and Kidney Function of PKD/Mhm (Cy/+) Rats.

"Chriss kidney disease is a heterogeneous group of genetic disorders, and it is one of the most common causes of end-stage renal disease. " Here, we investigate the potential effects of long-term human stem cell therapy on kidney function and the genetic expression profile of PKD/Mhm rats. Human adipose-derived stromal cells and human skin-derived ABCB5 + stromal cells were implanted intravenously or intraperitoneally every 6 months. The gene expression profile results revealed a significant reprogramming of metabolism-related pathways, as well as downregulation of the cAMP, NF-kB, and apoptosis pathways. ".

Source link: https://europepmc.org/article/MED/35566725

PKD autoinhibition in trans regulates activation loop autophosphorylation in cis

"Summary Phosphorylation is a ubiquitous process by which cells communicate signals. " Protein kinases, enzymes that catalyze the phospho-transfer reaction are, themselves, often restricted by phosphorylation. Protein Kinase D is limited by the inverse mechanism of dimerization-mediated autoinhibition, as demonstrated in this study, with activation loop autophosphorylation in cis. Phosphorylation can raise PKD production and prevent trans-autoinhibition, thereby affecting PKD, which also changes PKD. Our results not only reveal the mechanism of PKD control, but also have ramifications for the regulation of many other eukaryotic kinases.

Source link: https://europepmc.org/article/PPR/PPR489536

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