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Ovulation - BioProject

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Last Updated: 06 February 2022

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Ovulation suppression protects against chromosomal abnormalities in mouse eggs at advanced maternal age

With maternal age, the number of egg aneuploidy and trisomic pregnancies rises. These results show that ovulation suppression shields against Rec8 loss, thus preserving both sister chromatid cohesion and 3D chromatin structure and encouraging the production of euploid eggs. In mice, we find that the "maternal age effect" can be postponed. Long-term ovulation-suppressing conditions, according to the researchers, may possibly reduce the risk of Down's syndrome pregnancies in women of advanced maternal age. From GV oocytes of C57BL/6J 2-2. 5 month old and 20 snHi-C libraries of C57BL/6J 14-18 month aged mice, we created 20 snHi-C libraries of C57BL/6J 14-18 month age mice. We created 12 snHi-C libraries from GV oocytes of C57BL/ICRFat 14-15 month old virgin oocytes, 14 snHi-C libraries from GV oocytes of C57BL/ICRFat 14-15 month aged virgin oocytes of C57BL/ICRFat 14-15 month aged constant-mated mice, 14 snHi-C libraries from C57BL/ICRFat 14-15 month old oocytes of 2-2. 5 month old oocytesnHi-C libraries from C57BL/ICRFat oocytes of C57BL/ICRFat oocytes of C57BL/ICRFat oocytes of C57BL/ICRFat oocytes of C57BL/ICRFat oocytes of C57BL/ICRFat oocytes of C57BL/ICRFat 14-15 month aged oocytes of C57BL/ICRFat oocytes of C57BL/ICRFat oocytes of C57B/ICRFat 14-15 month aged o.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/718570

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions