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Osteoporosis - U.S. Department of Veterans Affairs

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Last Updated: 15 March 2022

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A role for the MEGF6 gene in predisposition to osteoporosis.

Osteoporosis is a common skeletal disorder characterized by bone tissue degeneration. Genes that may be attributed to disease susceptibility were found in high-risk osteoporosis pedigrees. Evidence of segregation with the disease phenotype was shown by a rare variant of MEGF6. The variant, according to predicted protein folding, could break the consistency of an EGF-like calcium-binding domain of MEGF6. Functional tests showed that complete absence of the requisite genes megf6a and megf6b in zebrafish resulted in significant delay in cartilage and bone formation. Various studies, including silico protein structure analysis, and functional assays point to a role for MEGF6 in osteoporosis in predisposition to osteoporosis.

Source link: https://doi.org/10.1111/ahg.12408


Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin.

Excess glucocorticoids, whether related to disease or iatrogenic, has bone resorption and decreases bone formation, and is a common cause of osteoporosis and bone fractures around the world. Sost-/-mic mice's increased bone mass with unchanged resorption is attributed to increased bone formation and improved resorption. However, bone mass and strength in Sost-/- mice's preservation was not due to the reduction of bone mass and strength, not to bone regeneration. Despite significantly reduced bone formation and increased apoptosis, activation of Wnt/+-catenin signaling by Sost/sclerostin deficiency maintains bone stability in the context of glucocorticoid excess. This crosstalk between glucocorticoids and Wnt/Catenin signaling may be able to halt bone loss caused by glucocorticoids and bone loss in diseases of unwanted hyperactivation of Wnt/>-catenin signaling and bone damage.

Source link: https://doi.org/10.1002/jbmr.2869

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions