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Osteoporosis - Springer Nature

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Last Updated: 15 June 2022

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Neridronate for transient osteoporosis of the hip in a child

"We herein describe a case of TOH in a 10-year-old boy treated at our pediatric rheumatology center and summarize the pediatric cases of TOH that were previously reported in literature. In our case report, there are two points of concern, the first one being the rare complication of TOH with a femoral physis fracture, and the second being complete recovery after the off-label therapy with bisphosphonates. This is the first report of neridronate employment in children impacted by TOH, as far as we know.

Source link: https://doi.org/10.1007/s00198-022-06324-y


Osteoporosis in children and adolescents: when to suspect and how to diagnose it

"Genetic and acquired pediatric bone disorders are fairly common and cause significant morbidity. " Particularly, medications that can adversely affect bone health and immobilization due to acute and chronic illnesses are among the leading risk factors for secondary osteoporosis, providing an indication to screen for bone mineral density and vertebral fractures. Conclusions : Osteoporosis in children requires examination and/or referral to a pediatric bone specialist. Pediatricians have the opportunity to increase bone mass accrual and musculoskeletal stability in osteoporotic children as a result. What is New: U2022 Pediatricians have a chance to increase bone mass accrual and musculoskeletal stability in osteoporosis-prone children and children at risk of osteoporosis. 2022: U2022 We provide an extensive yet concise summary of osteoporosis risk factors and the diagnostic work-up of pediatric patients suspected of osteoporosis.

Source link: https://doi.org/10.1007/s00431-022-04455-2


Osteoporosis-pseudoglioma syndrome in four new patients: identification of two novel LRP5 variants and insights on patients’ management using bisphosphonates therapy

"Summary" is a film that compares four new patients with osteoporosis-pseudoglioma syndrome and determines their reaction to bisphosphonate therapy. Biallelic mutations in the gene encoding low-density lipoprotein receptor-related protein 5 (OPPG) are responsible for OPPG. Methods We present the clinical, radiological, and molecular findings of four new patients with OPPG from Egypt's four new patients. Conclusions All patients had decreased bone mineral density with a variety of fractures per year, rather than bone abnormalities and the typical phenotype associated with OPPG. Mutation studies of the LRP5 gene revealed three distinct homozygous variants, including two novel ones, c. 7delG and c. 3280G> A. The use of bisphosphonate therapy was benevolious, but intravenous bisphosphonate therapy produced a more positive reaction. Four patients with OPPG were analyzed and genetically modified by four researchers with OPPG, as well as two new LRP5 variants, thus broadening the mutational spectrum of OPPG. ".

Source link: https://doi.org/10.1007/s00198-022-06313-1


Comparative risk of acute myocardial infarction for anti-osteoporosis drugs in primary care: a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice Research Database and the Catalan SIDIAP Database

"Summary" is a short term used to assess the possibility of acute myocardial infarction in patients taking osteoporosis drugs. Patients with diabetes and persistent kidney disease were at an elevated risk of seizing SERMs. The findings point to alendronate's cardiovascular health as a first-line option for osteoporosis therapy. This research was published in two primary care record databases focusing on UK NHS and Catalan healthcare patients between 1995 and 2014, respectively. CPRD's findings An acute myocardial infarction risk was 10% in users of other bisphosphonates, as opposed to alendronate users within CPRD. Conclusions This report provides more insight into the danger of acute myocardial infarction in patients receiving osteoporosis therapy. The findings point to alendronate's cardiovascular stability as a first-line option for osteoporosis therapy.

Source link: https://doi.org/10.1007/s00198-021-06262-1


Supporting patients to get the best from their osteoporosis treatment: a rapid realist review of what works, for whom, and in what circumstance

"Summary Systematic reviews that evaluate the effectiveness of interventions to improve medicine optimization do not include information about how or why they work" summarizes the results. This realist analysis found that interventions that effectively optimize medications use in osteoporosis included opportunities to improve patient satisfaction with disease and treatment, as well as primary care clinician decision making. Conclusions We found 5 contextual timepoints for the individual with osteoporosis, as well as the healthcare system. In increasing rates of treatment acceptance and adherence, supporting primary care clinician decision making and integrating primary and secondary care services also appears to be important. "We found it necessary for further study to find a cost- and clinically cost-effective long-term care for people with osteoporosis" is needed.

Source link: https://doi.org/10.1007/s00198-022-06453-4


Global, regional prevalence, and risk factors of osteoporosis according to the World Health Organization diagnostic criteria: a systematic review and meta-analysis

"Abstract" is a form of osteoporosis that occurs worldwide, regionally, and risk factors. Osteoporosis is a common metabolic bone disorder in the elderly, often resulting in bone pain and an elevated risk of fragility fracture, but few systematic reviews have influenced global strategies for the condition. Hence, we assembled epidemiologic evidence to determine osteoporosis' global, regional incidence, and potential risk factors. To find population-based studies that reported osteoporosis based on World Health Organization criteria, we carried out a comprehensive literature search through PubMed, EMBASE, Web of Science, and Scopus. The global prevalence of osteoporosis and osteopenia was 19. 7% and 39. 4% respectively. The incidence in developing countries was higher than in developed countries than in developed countries. Our report shows a significant prevalence of osteoporosis among the general population based on WHO estimates, although the incidence varies widely between countries and regions. ".

Source link: https://doi.org/10.1007/s00198-022-06454-3


Sex-specific bi‑directional association between osteoporosis and depression from the national representative data of South Korea

"The odds ratio of the incident osteoporosis among depression patients without a history of osteoporosis was estimated by multivariable logistic regression adjusted for potential confounders. " As a result, male depression patients aged under the age of 50 years had higher ORs for osteoporosis than those without depression. Female osteoporosis patients had lower odds of depression than those without osteoporosis, particularly in women aged 50 years and older. Depression has a strong positive correlation with the occurrence of osteoporosis in young male adults, and osteoporosis has a negative relationship with female adult depression.

Source link: https://doi.org/10.1038/s41598-022-13401-z


The integrative analysis of competitive endogenous RNA regulatory networks in osteoporosis

"Osteoporosis is a common bone disease of old age due to the lack of bone resorption and bone formation. " A ceRNA network containing 7 target circRNAs, 5 target miRNAs, and 38 target genes was designed in the Netherlands, along with the prediction of the links between DEGs, DEMs, and DECs. Using total RNAs isolated from the femurs of normal and ovariectomized Wistar rats, the researchers found that MFAP5, CAMK2A, and RGS4 in the ceRNA network were closely associated with osteoporosis. Then a circRNA_0028877, hsa_circR_0028877, DIRAS2, and MAPK4 revealed a strong correlation with osteogenic genes, with osteogenic genes corresponding to osteogenic genes, according to the nephrologists. Our research revealed in OP that there were potential links between circRNAs, miRNAs, and mRNAs, indicating that the ceRNA mechanism may play a role in the occurrence of OP. ".

Source link: https://doi.org/10.1038/s41598-022-13791-0


Osteoporosis management and secondary fragility fracture rates in patients with multiple sclerosis: a matched cohort study

"Patients with multiple sclerosis had more primary hip fractures than controls, with much higher incidences of falls within three years post-fracture. " However, multiple sclerosis patients were more likely to be diagnosed with osteoporosis and treated with drugs than osteoporosis patients. Introduction This study was conducted to determine osteoporosis management, falls, and secondary fractures among patients with MS versus matched controls. Results The 2,320 controls were matched with 1,232 patients with primary fragility fractures in MS. Primary hip fractures were more common in the MS cohort. Patients with MS were significantly more likely to receive a formal osteoporosis diagnosis and osteoporosis pharmacotherapy after the initial fracture. Conclusions "Primary hip fracture fractures were significantly more prevalent in MS patients than in matched controls. ".

Source link: https://doi.org/10.1007/s00198-022-06451-6

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions