Advanced searches left 3/3

Osteoporosis - PubAg

Summarized by Plex Scholar
Last Updated: 15 October 2021

* If you want to update the article please login/register

Botanicals in Postmenopausal Osteoporosis

Osteoporosis is a systemic bone illness defined by decreased bone mass and the deterioration of bone microarchitecture causing bone delicacy and a boosted threat of cracks. Conventional anti-osteoporotic pharmaceutics work in the treatment and prophylaxis of osteoporosis, nevertheless they are connected with various side effects that push many women into seeking botanicals as an alternate therapy.

Source link: https://pubag.nal.usda.gov/catalog/7388563


Effects of bisphosphonates on osteoporosis: Focus on zoledronate

Osteoporosis is a bone disease that primarily influences older people and postmenopausal women. This family has several positive results on bone cells, consisting of promoting bone recovery, improving bone mineral density, decreasing bone resorption, avoiding pathologic cracks, suppressing bone turnover, and modulating bone makeover. On the other hand, there have additionally been undetermined reports that BPs may have a desirable and even damaging effect on osteoporotic patients. Zoledronate is an amino-BPs and nitrogen-containing drug which is the most effective BPs on osteoporosis treatment or prevention.

Source link: https://pubag.nal.usda.gov/catalog/7159539


Osteoporosis: A role for lipids

An inverse relationship between bone marrow adiposity and bone mass has been described in various physical and pathological problems, consisting of osteoporosis. In osteoporotic patients, lower bone mass thickness is undoubtedly connected with greater BM fat content, recommending a potential duty for bone lipids in the OP pathogenesis. Human data are in some way contradictories pertaining to bone lipid trademark relevant to OP, and animal data are required to support on one or another way the human monitorings. Bone lipid signature linked to OP needs to be cleared up if we wish to recognize better their roles in OP. In that context, by utilizing an ovariectomy-induced OP murine design and looking at lipids in 2 bone areas: BM and mineralized tissue, our first obstacle was to recognize local lipid adjustments in connection with OP, in sight to discover later on the mechanisms through which those substances could change bone top quality, specifically during the mineralization procedure.

Source link: https://pubag.nal.usda.gov/catalog/7081911


Reprogrammed intestinal functions in Astragalus polysaccharide-alleviated osteoporosis: combined analysis of transcriptomics and DNA methylomics demonstrates the significance of the gut–bone axis in treating osteoporosis

Researchers have noted that organ-- organ communication in between bone and intestine has considerable effects on bone wellness and its associated illness. In this research study, we collected colonic epithelial cells from dexamethasone-induced osteoporotic rats and Astragalus polysaccharide -relieved osteoporotic rats and utilized transcriptome sequencing to examine the useful changes that took place in the intestine. Principal element evaluation showed that both dexamethasone and APS reprogrammed the genetics expression profile of the intestinal tract. More evaluation showed that APS could restore digestive functions by reversing the expression of 53 DEGs in osteoporotic rats. Recovery of osteoclast distinction and the calcium signalling pathway may add to the enhancement of osteoporosis. Using methylC-capture sequencing, we researched the changes in DNA methylation and carried out epigenetic evaluation of dexamethasone- and APS-induced gene expression changes. Our results support the existence of an intestine-- bone axis and recommend new restorative opportunities for the treatment of osteoporosis via the intestine-- bone axis.

Source link: https://pubag.nal.usda.gov/catalog/7390840


Plastrum testudinis extract suppresses osteoclast differentiation via the NF-κB signaling pathway and ameliorates senile osteoporosis

Plastrum testudinis essence has been authorized to advertise the osteogenic differentiation of bone marrow-derived mesenchymal stem cells in vitro. However, the mechanism by which PTE minimizes osteoclast differentiation has not yet been reported. To explore the capacity of PTE as a therapeutic treatment for bone loss brought on by senescent osteoporosis. We evaluated whether PTE might inhibit RANKL-induced osteoclast differentiation both in vitro and in vivo, and investigated PTE-induced phenotypes of human peripheral blood monocytes. We discovered that PTE hindered osteoclast differentiation and bone traction in vitro in a concentration-dependent manner which PTE treatment is most effective during the beginning of osteoclastogenesis. Significantly, we additionally found that PTE hindered RANKL-induced osteoclast differentiation in human outer blood monocytes. Our results recommend that PTE treatment reduces osteoclastogenesis and relieves bone loss triggered by SOP by uniquely blocking the nuclear translocation of NF-κB/ p50.

Source link: https://pubag.nal.usda.gov/catalog/7369493


Lycopene ameliorates diabetic osteoporosis via anti-inflammatory, anti-oxidation, and increasing Osteoprotegerin/RANKL expression ratio

Lycopene treatment improved bone mineral density, brought back bone mechanical and bone Micro-CT specifications of diabetic rats. Ultimately, lycopene decreased serum inflammatory cytokines levels and increased lotion anti-oxidant signs levels. The bone and serum OPG, RUNX 2 expression levels were up-regulated by lycopene in diabetic rats, and the OPG/RANKL proportion was also up-regulated. This study showed that lycopene might relieve diabetic person induced bone loss through anti-inflammatory, anti-oxidation, and enhancing OPG/RANKL ratio in diabetic person rats. Lycopene might be used for nutritional intervention in patients with diabetic osteoporosis.

Source link: https://pubag.nal.usda.gov/catalog/7402271


Physicochemical properties, digestibility and anti-osteoporosis effect of yak bone powder with different particle sizes

There is little research about the result of bit size on the physicochemical properties and digestibility of yak bone powder, as well as its anti-osteoporosis task. The outcomes revealed that smaller sized MPS significantly increased water holding capacity and protein solubility without transforming make-up. The bone mineral thickness of ovariectomized rats was undoubtedly boosted by controling bone turnover pens, therefore potentially losing light on osteoporosis remission. As a result, YBP can be generated in relatively large particle size without compromising food sensory top quality, the processing time of which could be reduced for higher productivity and reduced expense.

Source link: https://pubag.nal.usda.gov/catalog/7369848


Effects of compound deer bone extract on osteoporosis model mice and intestinal microflora

The preventive and therapeutic mechanisms of CDBE on osteoporosis were examined by observing the lotion bone‐related biochemical indicators, bone trabecular micro‐structure and digestive tract vegetation in ovariectomized osteoporosis model mice, in order to offer a scientific theoretical basis for the further research study on the effect of CDBE on osteoporosis, and the prevention and treatment of osteoporosis with scientific standard Chinese medications. The biochemical signs connected to osteoporosis were spotted, the right proximal tibia was checked by Micro‐CT, the intestinal microflora in the colon materials were examined, and the adjustments of microflora were taken as the major target to evaluate the result of CDBE on the digestive tract microflora in the design mice. CDBE can make the intestinal plants of osteoporosis version mice have a tendency to healthy mice in varieties and amount. CDBE can boost the symptoms of postmenopausal osteoporosis in mice, with a positive effect on the intestinal flora of postmenopausal mice.

Source link: https://pubag.nal.usda.gov/catalog/7414149


Strontium gluconate potently promotes osteoblast development and restores bone formation in glucocorticoid-induced osteoporosis rats

Glucocorticoid-induced osteoporosis has emerged as a difficulty after lasting glucocorticoid administration throughout the clinical therapy of varied illness. Thirty-two SD rats were separated into 4 groups to discover the impacts of GluSr on osteoporosis rescue in vivo. GluSr properly advertised osteoblast survival, prevented osteoclast differentiation and brought back bone development in GIOP rat models. Microarray evaluation of the thigh from GIOP rats treated with GluSr exposed that the signalling paths of the glucocorticoid receptor, oestrogen receptor gene and vitamin D receptor were entailed in bone repair by GluSr.

Source link: https://pubag.nal.usda.gov/catalog/7326600

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions