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"Background: Glucocorticoid-Induced osteoporosis is the most common secondary osteoporosis, alendronate, and teriparatide are commonly used in GIOP therapy. Glucocorticoid doses greater than 7. 5 mg/d were observed for more than three months before diagnosis with ALE and TPTD. The influence index of continuous measurements uses the risk ratio and its 95% confidence interval as the influence index of discontinuous results, while the standardized mean difference and its 95% CI are used as the influence index for continuous measurement. TPTD can reduce the incidence of new vertebral fractures in comparison to ALE, according to our study. Compared to ALE, TPTD improved LS bone mineral density, TH BMD, and FN BMD BMD. Conclusions: TPTD is a safer drug to minimize vertebral fracture risk in patients with GIOP, compared to ALE. "In addition, long-term use of TPTD can raise the bone mineral density of LS, FN, and TH. ".
Source link: https://doi.org/10.1371/journal.pone.0267706
"The purpose of this research was to determine the histological and histomorphometric effects of intermittent PTH administration on osseointegration in a glucocorticoid-induced osteoporotic rabbit model. " With ovariectomy and glucocorticoid administration, fifteen female New Zealand rabbits were ready for the osteoporosis model. The maximum removal torque of the implanted implant and bone implant contact ratio were determined after four weeks. Compared to those of the PTHa and Control groups, the RT and BIC values were significantly higher in the PTHa group. In addition, the bone mineral densities and Hounsfield units in PTHa's PTHa group were significantly higher in the PTHa group than those in the PTHb and Control groups. Continuous administration of PTH increased bone density and bone growth around the implant placement site, as well as systemic bone formation," according to histologic and histomorphometric studies.
Source link: https://doi.org/10.1371/journal.pone.0269040
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