Osteoporosis - DOAJ

Osteoblast lineage Sod2 deficiency leads to an osteoporosis-like phenotype in mice

"Using a mouse model of osteoblast lineage cells with Sod2 deficiency, bone loss in trabecular and cortical bones was followed by decreased osteoblast development, increased adipocyte accumulation in the bone marrow, and enhanced osteoblast differentiation and osteoclastogenesis, which can be explained by altered mesenchymal progenitor cell differentiation and osteoclastogenesis. " To date, there are only a few studies that show a causal correlation between mtROS and cell senescence in tissue in vivo. Targeting SOD2 to improve redox homeostasis could be a potential therapeutic tool for preserving bone health during aging. ".

Source link: https://doi.org/10.1242/dmm.049392

Advances in Our Understanding of the Mechanism of Action of Drugs (including Traditional Chinese Medicines) for the Intervention and Treatment of Osteoporosis

"Osteoporosis is a silent disease in which bone mass loss and bone density does not cause obvious signs, resulting in ineffective care and preventive steps. " Patients with OP-related fractures become more prominent over time, and only a small number of patients are diagnosed with bone mass and bone density as a result of OP-related fractures. In this review, scientific progress related to common anti-OP drugs in these three classes as well as targeted therapies is analyzed to help researchers and clinicians understand their behavior and support novel drug discovery.

Source link: https://doi.org/10.3389/fphar.2022.938447

Histological and histomorphometric aspects of continual intermittent parathyroid hormone administration on osseointegration in osteoporosis rabbit model

"The aim of this research was to examine the histological and histomorphometric effects of intermittent PTH administration on osseointegration in a glucocorticoid-induced osteoporotic rabbit model. " With ovariectomy and glucorticoid administration, fifteen female New Zealand rabbits were set for the osteoporosis model. The maximum removal torque of the implanted implant and bone implant contact ratio was determined after four weeks. In the PTHa group, the RT and BIC values were significantly higher than those of the PTHa and Control groups, respectively. In addition, bone mineral densities and Hounsfield units in the PTHa group were significantly higher in the PTHa group than those in the PTHb and Control groups. Continuous administration of PTH led to bone density and bone formation around the implant placement site, as well as systemic bone formation," according to Histologic and histomorphometric studies.

Source link: https://doaj.org/article/fcbbb25b1b534b0386c704b3259557ff

Combination of Calcitriol and Zoledronic Acid on PINP and β-CTX in Postoperative Patients with Diabetic Osteoporosis: A Randomized Controlled Trial

"To investigate the effects of calcitriol and zoledronic acid in posterior cruciate ligament tibial avulsion fractures of the knee joint in diabetic osteoporosis patients. " The two groups were compared with respect to bone mineral density and bone metabolism indexes, pain tolerance, knee joint mobility, and incidence of refracture. VAS scores decreased in both groups, and Lysholm scores increased in the two groups after therapy, with more notable changes in the observation group compared to the control group. After the posterior cruciate ligament tibial attachment fracture of the knee joint yields, Calcitriol and zoledronic acid were used in diabetic osteoporosis patients, a promising result in raising bone mineral density and bone metabolism measurements, relieving pain, improving knee joint function, and reducing the chance of refracture were present in patients with diabetic osteoporosis.

Source link: https://doi.org/10.1155/2022/6053410

The integrative analysis of competitive endogenous RNA regulatory networks in osteoporosis

"Abstract Osteoporosis is a common bone disease of old age that results from a combination of bone resorption and bone formation. " CircRNAs are a class of endogenous non-coding RNAs involved in gene regulation that may play a role in the formation of OP. A ceRNA network containing 7 target circRNAs, 5 target miRNAs, and 38 target genes was built based on the ne's findings, as well as the analysis of the ties between DEGs, DEMs, and DECs. MFAP5, CAMK2A, and RGS4 in the ceRNA network were closely associated with osteoporosis, according to then the RNA-seq analysis by using total RNAs isolated from the femurs of normal and ovariectomized Wistar rats' femurs. Then a circRNAu2013miRNA gene subnetwork was developed, and the qRT-PCR analysis of human bone tissue from the femoral head revealed a significant correlation with osteogenic genes, according to the researcher.

Source link: https://doi.org/10.1038/s41598-022-13791-0

Sex-specific bi‑directional association between osteoporosis and depression from the national representative data of South Korea

"The odds ratio of the incident osteoporosis among depression patients without a history of osteoporosis was estimated by multivariable logistic regression adjusted for potential confounders. " As a result, male depression patients aged under the age of 50 years had higher ORs for osteoporosis than those without depression. Female osteoporosis patients had lower odds of depression than those without osteoporosis, especially in women aged 50 years and older. Depression has a strong positive correlation with the occurrence of osteoporosis in young male adults, and osteoporosis has a negative association with female adult depression.

Source link: https://doi.org/10.1038/s41598-022-13401-z

Genetic variation in WNT16 and its association with bone mineral density, fractures and osteoporosis in children with bone fragility

Several genome-wide association studies, GWAS meta-analysis, and mouse studies have shown that wingless-related integration site 16 gene is positively linked to bone mineral density, cortical bone thickness, bone density, and fracture risk. " We hypothesized that pathogenic variants and genetic variations in WNT16 may have contributed to skeletal fragility in affected children. WNT16 gene expression at a mRNA level in fibroblast cultures was shown to be elevated in fibroblast cultures. This variant was also related to increased WNT16 gene expression at a mRNA level in fibroblast cultures. Genetic WNT16 variation may have a role in childhood osteoporosis, but it is not a common cause of childhood skeletal fragility. ".

Source link: https://doi.org/10.1016/j.bonr.2022.101525

Diagnostic yield of bone fragility gene panel sequencing in children and young adults referred for idiopathic primary osteoporosis at a single regional reference centre

"Methods: In this study, sixty-six patients diagnosed with primary osteoporosis were included; patients with signs of osteogenesis imperfecta or other recognized osteoporosis disorders were excluded; patients with osteoporosis were excluded. In all of these patients, a bone fragility gene panel analysis was performed as part of the initial assessment procedure. The children had a significantly lower incidence of vertebral fractures and a higher risk of peripheral fractures compared to the adults. The heterozygous pathogenic variant in 27% of patients and the heterozygous p. LRP5 variant in 11% of them allowed the identification of the heterozygous pathogenic variant in 27 percent of patients and the heterozygous pathogenic variant in 11% of them. Both children and adults had the same frequency of the p. LRP5 variant. In this report, we reported the presenting findings and bone characteristics in a large population of children and young adults with idiopathic primary osteoporosis. ".

Source link: https://doi.org/10.1016/j.bonr.2022.101176

Intravenous Zoledronate 4 mg for the treatment of post-menopausal osteoporosis: A prospective open-labeled study

"Zoledronate 4 mg, which is approved for the treatment of cancer-related hypercalcemia, may be a good alternative for Asian women with smaller stature. " Objectives: To determine the efficacy and safety of Zoledronate 4 mg IV once a year for the treatment of post-menoporosis. All patients were given a dose of IV Zoledronate 4 mg. Bone mineral density was determined at baseline and 12 months after treatment. After treatment, the lumbar spine BMD increased by 0. 833 g/cm2 to 0. 862 after treatment. BMDs were not significant different between baseline and femoral neck BMDs at 12 months after treatment. After 12 months of therapy, Zoledronate 4 mg increased lumbar BMD and reduced u03b2-CTX and P1NP dramatically. Zoledronate 4 mg may be a cheaper alternative to Zoledronate 5 mg for the treatment of post-menopausal osteoporosis.

Source link: https://doi.org/10.1016/j.bonr.2021.101153

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