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Osteoporosis - ClinicalTrials.gov

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Last Updated: 15 June 2022

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Osteoporosis Patient Education in Danish Municipalities: an Evaluation of Existing Programs and Recommendations for Further Practice

"In this quasi-experimental review, the investigators will conduct an effect review that compares an intervention group of osteoporosis patients who have been involved in patient care in a municipality with a control group who has not participated. " The intervention group is made up of people who have already participated in osteoporosis patient education from 2016 to 2020. The control group will be withdrawn via the Danish Health Data Authority, and it will include people who have not participated in osteoporosis patient education. For each individual in the intervention group, one control will be matched on gender, age, disease, time of diagnosis, and type of fracture before the index date. The Danish Health Data Authority will conduct the register extraction, which will include details on fractures and adherence as well as statistics on adherence and adherence. The intervention group and the control group will be compared in the reports with respect to all outcomes. ".

Source link: https://clinicaltrials.gov/ct2/show/NCT05401968


Comparing Strategies Targeting Osteoporosis to Prevent Recurrent Fractures: C-STOP# Randomized Trial

"Guidelines recommend aggressive therapy in older patients with osteoporosis-related fractures because the likelihood of another fracture is 20 percent within one year and because bisphosphonate therapy reduces fracture risk by half. " However, only about 10% of older outpatients are treated for osteoporosis in the year post-fracture, and the most potent multifaceted therapies tested so far have only raised post-fracture osteoporosis treatment rates with bisphosphonates to 22%. Osteoporosis case-managers will identify older fracture patients in Emergency Departments and Fracture Clinics; order bone mineral density tests; consult with patients to advise them and discuss their findings; and finally administer and prescribe bisphosphonate treatment to those with low BMD. Hypothesis: In comparison to a previously proven effective and cost-saving multifaceted osteoporosis treatment, an osteoporosis case-manager will efficiently and cost-effectively raise the incidence of BMD testing and bisphosphonate therapy in older high-risk patients with upper extremity fractures in older high-risk patients with upper extremity fractures. Objectives: To determine whether an osteoporosis case-manager's approach could: Increase rates of osteoporosis treatment more than a multifaceted approach. More information about case-managers and standard care can be obtained. More than a multifaceted intervention is more cost-effective than a multifaceted approach. a scopist approach Increased rates of osteoporosis treatment are more effective than a multifaceted intervention. More information about case-managers or regular care can be blinded The case-manager's incremental costs and effectiveness will then be compared to both the multifaceted intervention and normal care based on 1-year results and micro-costing results from the trial and our published Markov decision analytic model for osteoporosis quality improvement initiatives.

Source link: https://clinicaltrials.gov/ct2/show/NCT01401556


Feasibility of a Novel Resistance Exercise in Individuals With Osteoporosis

"Osteporosis and osteoporosis-related fractures in 2008 was expected to cost osteoporosis and osteoporosis-related fractures in 2008. " The aim of this research is to determine the success of novel progressive muscle endurance training in overweight postmenopausal women with low bone mass. Via activity monitors will monitor physical fitness. Blood will be collected to determine bone and muscle biomarkers. The findings from this study will help us to determine the feasibility of a resistance muscle training program in postmenopausal women with low bone mass.

Source link: https://clinicaltrials.gov/ct2/show/NCT05060380


Novel Precision Medicine Approach to Treatment of Osteoporosis Based on Bone Turnover

"High bone turnover and increased bone turnover can be characterized by increased bone turnover and increased bone turnover, as well as bone formation. " The primary abnormality is age-related bone loss, which is often associated with decreased bone turnover and reduced bone formation. The investigators intend to develop two specific goals: Aim 1 to establish a novel precision medicine approach to osteoporosis prevention and initial treatment with anabolics are based on low bone turnover and initial treatment with anabolics; and Aim 2 to find a non-invasive means for diagnosing osteoporosis in osteoporosis treated in osteoporosis in osteoporosis in osteoporosis in osteoporosis in osteopo In addition, blood samples of carboxylated osteocalcin will be tested to see whether they are good - alone or in combination with other bone markers - for detecting low bone turnover that occurs in age-related bone loss. Participants in Low-turnover are either randomized 1:1 to treatment with the anabolic teriparatide Group 1 or the care antiresorber alendronate Group 2 for one year. For one year, normal-high turnover participants Group 3 will be treated with the appropriate comparison group for non-invasive turnover monitoring. Bone mineral density measurements at baseline and one-year will be performed by DXA and 1-year changes in BMD will be compared between groups. Low turnover, age-related osteoporosis, needs to be diagnosed and treated differently from estrogen deficiency-related osteoporosis, according to the investigators' central hypothesis.

Source link: https://clinicaltrials.gov/ct2/show/NCT05151484


A Multi Center, Randomized, Open-label, Parallel, Phase IV Clinical Trial to Evaluate Efficacy and Safety of MASI BONE S (Alendronate Sodium Trihydrate) in Postmenopausal Women With Osteoporosis

"The effect of Masibone S and Fosamax on bone mineral density in postmenopausal women with osteoporosis will be measured and analysed. " The primary endpoint is the difference between bone mineral density change at lumbar spine measured by DEXA between two groups, which is the main endpoint.

Source link: https://clinicaltrials.gov/ct2/show/NCT05387200

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions