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The reduction of bone mineral content and bone strength that leads to fractures are two features of osteoporosis. " Bone growth and their ability to repair appear in osteoporosis therapy, according to a promising tool in osteoporosis therapy. Our findings revealed that PRHD and its reduction of osteoclast function by a large margin. Furthermore, in this instance, we also observed good anti-inflammatory activity in pre-osteoblasts and osteoclasts, which was also illustrated by reduced expression of Il1b, Tnfa, and Tgfb. "through the ALP-OCL axis, increased recognition of bone remodeling, namely osteopontin, osteocalcin, and alkaline phosphatase, appear to establish the role of PRHD@MnFe2O4 in the promotion of differentiation of pre-osteoblasts. ".
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