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Organ Transplantation - U.S. Department of Veterans Affairs

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Last Updated: 11 February 2022

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Evolution of Cytomegalovirus-Responsive T Cell Clonality following Solid Organ Transplantation.

In the first year after transplantation in human subjects, we used single cell TCR sequencing to see how memory inflation affected the clonality and variety of the CMV-responsive CD8 and CD4 T cell repertoire. We observed CD8 T cell inflation in clonal diversity but there were no shifts in clonal consistency, indicating homeostatic stability in clones. Contrarily, the CD4 repertoire remained varied and stable over time, with no signs of CMV-responsive CD4 T cell expansion apparent.

Source link: https://doi.org/10.4049/jimmunol.2100404


Functional Consequences of Memory Inflation after Solid Organ Transplantation.

Memory inflation occurs as a result of CMV reactivation, which causes memory expansion, in which CD8 T cells increase over time. We used single-cell-matched TCR and targeted gene expression sequencing to determine whether memory inflation in human subjects improves T cell differentiation and function in the first year after transplantation in human subjects changes T cell differentiation and function, leading to T cell differentiation and function. Expanded T cell clones exhibited a terminally differentiated, immunosenescent, and polyfunctional phenotype, whereas rare clones were less distinct, with a terminally distinguishable, expanded T cell clone phenotype. During the post-transplant clonal expansion, CMV-responsive CD8 T cells differed during the transition period from pre- to posttransplantation period, but they retained their differentiation state and functional capacity.

Source link: https://doi.org/10.4049/jimmunol.2100405

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions