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Organ Transplantation - Europe PMC

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Last Updated: 19 April 2022

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Challenges facing Indigenous transplant patients living in Canada: exploring equity and utility in organ transplantation decision-making.

Indigenous peoples in Canada and in the Circumpolar North face a higher incidence of disease resistance, which contributes to end-stage organ failure and organ transplantation, among other things. Think tank members, made up of Indigenous cultural leaders, elders, and people with lived experience in ODT, as well as medical and advocacy exports, have highlighted equity and utility issues as top concerns over the past three years, as well as ways in which these problems can be addressed.

Source link: https://europepmc.org/article/MED/35200099


Solid Organ Donation and Transplantation Activity in the Eurotransplant Area During the First Year of COVID-19.

Background Transplantation work during the first wave of the coronavirus disease 2019 pandemic was severely affected around the world. During the first 12 months of the pandemic, this retrospective review sought to investigate the effect of COVID-19 on organ donation and transplantation in the Eurotransplant zone. Overall, the number of organ donors decreased by 18. 3% and the number of organ transplantations by 12. 5% compared to previous years. In period 2 by 5. 2% and 16. 4% respectively, and in period 3 by 21. 9 percent and 16. 4%, respectively, in period 1 by 23. 2 percent and 16. 5%. During the second wave's severity, organ donation and transplantation decreased dramatically; however, during the second wave's severity, the decline was similar to that of the first wave.

Source link: https://europepmc.org/article/MED/35411875


The Global Impact of COVID-19 on Solid Organ Transplantation: Two Years Into a Pandemic.

With transplant rates returning to pre-emic rates, transplant rates have increased in tandem infections of acute respiratory syndrome coronavirus 2 infection risk and excess deaths among transplant recipients. Vaccine outcomes in SOT recipients are considerably lower than the general population, and SOT recipients remain at a greater risk of adverse outcomes if they develop COVID-19. We summarize the global impact of COVID-19 on transplant activity, donor monitoring, and patient outcomes over the past two years, and suggest that transplant recipients be prepared for future pandemics.

Source link: https://europepmc.org/article/MED/35404911


Necroptosis in Solid Organ Transplantation: A Literature Overview

During solid organ transplantation, Ischemia-reperfusion disease is present in various stages. Although the pattern of sterile inflammation during IRI is similar among different organs, the underlying mechanisms are not clear. Receptor-interacting protein kinase 3 and mixed-lineage kinase pseudokinase are thought to be crucial in the introduction of necroptosis. In this review, we summarized information on the mechanisms of sterile inflammation processes in SOT, with a special emphasis on necroptosis and IRI, as well as protective strategies.

Source link: https://europepmc.org/article/MED/PMC8998671


Necroptosis in Solid Organ Transplantation: A Literature Overview.

Although the cycle of sterile inflammation during IRI is similar among various organs, the underlying mechanisms are not clear. Receptor-interacting protein kinase 3 and mixed-lineage kinase domain-like pseudokinase are considered to be instrumental in the preparation of necroptosis. In this review, we summarize information on the mechanisms of sterile inflammation processes in SOT, with a special emphasis on necroptosis and IRI and discussion of protection strategies.

Source link: https://europepmc.org/article/MED/35409037

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions