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Organ Transplantation - DOAJ

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Last Updated: 19 April 2022

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Overall mental distress and health-related quality of life after solid-organ transplantation: results from a retrospective follow-up study

Abstract Background The aim of this retrospective review was to determine the degree of general psychological distress in a group of solid-organ transplantation recipients after liver, heart, or lung transplantation. Methods 123 SOT patients enrolled in this investigation during the study period were enrolled in the study for a total of 24. 6 months after transplantation. The Transplant Evaluation Rating Scale was used to rate the degree of change in psychosocial functioning among transplantation candidates before transplantation. 39 transplantation recipients suffered clinically significant overall mental disturbance, somatization disorders, anxiety disorders, depression, and phobic anxiety signs were all present, according to the Global Severity Index of the SCL-90-R. Obsessive-compulsive symptoms, somatization signs, depression symptoms, anxiety alerts, and phobic anxiety indicators were among the most common findings. As measured in the TERS, transplantation recipients with significant emotional distress had significantly lower rates of adjustment in psychosocial functioning before transplantation than those without general mental distress.

Source link: https://doi.org/10.1186/1477-7525-11-15


Nanoparticle-Based Modulation and Monitoring of Antigen-Presenting Cells in Organ Transplantation

During allograft rejection, antigen-presenting cells predominate, resulting in a tense environment in which allograft rejection and initiation of allograft rejection establishes a highly inflammatory environment in which allospecific T cells are primed. A variety of drugs that are safe in the short-term, but with significant long-term side effects and high toxicity, are among the current clinical protocols to prevent allograft rejection. Nanoparticles are also used as an integrative imaging moieties to measure inflammation for diagnostic purposes. Therefore, nanotechnology technologies could be a cost-effective way to provide and monitor the success of immunosuppressive therapy in organ transplantation with the ability to increase transplant patients' clinical care.

Source link: https://doi.org/10.3389/fimmu.2017.01888


The enigmatic nature of altruism in organ transplantation: a cross-cultural study of transplant physicians' views on altruism

A new breed of living organ donation, anonymous and non-directed, as well as living altruistic donation, has brought the subject into sharper focus. Transplant doctors' thoughts on altruism may have a deterministic donor's attitude and behavior toward living altruistic donors. Results of 27 French and 19 Quebec transplant physicians participated in individual, semi-structured interviews between October 2004 and December 2005. Conclusions The transplant physicians' discourses on altruism were remarkably diverse, prompting us to question the validity of organ transplantation and the appropriateness of the term "living altruistic donation" in the context.

Source link: https://doi.org/10.1186/1756-0500-3-216


Organ transplantation from deceased donors with cancer: is it safe?

Low-level evidence must continue to be based on low-level evidence, given the anecdotal quality of case studies and assembled collection of evidence that will continue to be based on clinical findings related to organ use from donors with malignancy. Despite this limitation, the evidence shows that not all donor neoplasms have the same risk of transmission to the recipient, and that it is crucial to determine whether or not a donor organ transplant or discard a given organ. This research explores the case for investigating organ transplantation in the case of certain donor malignancies, as well as the reasons that should be considered in such decisions. Organ transplantation, donor organs, malignancy, and complications are among the key words being considered in addition to those patients' transplantation.

Source link: https://doaj.org/article/46f339c691474b839cd725d402324a32


Ethical and Legal Implications of Elective Ventilation and Organ Transplantation: “Medicalization” of Dying versus Medical Mission

The shortage of organ donation is offset by the availability of organ donation. Elective ventilation, i. e. the use of ventilation for the sole purpose of retrieving the organs of patients close to death, is a viable option. In the Italian context, we have investigated the legal context of the organ donor's death and the possibility of EV in the Italian context. We believe that the real problem is in the patient's and his/her orientation toward the specific goal of organ donation.

Source link: https://doi.org/10.1155/2014/973758


Gene Expression Profiling in Organ Transplantation

Patients at risk of allograft rejection or those who will develop tolerance so immunosuppression could be safely minimized or even completely banned within the transplant community. However, gene expression analysis using the RTPCR method is now recommended because microarray experiments are costly and time-consuming, and their statistical analysis is often difficult. A variety of studies have shown that gene expression profiling is feasible, and there are several studies proving that gene expression profiling is possible.

Source link: https://doi.org/10.4061/2011/180201


Interprofessional communication in organ transplantation in Gauteng Province, South Africa

The transplant process is essential to the transplant process in South Africa, but it is difficult in South Africa due to the country's healthcare system's inherent health problems, the design of transplantation as a medical procedure with inherent psychological problems, and the large number of professionals involved. Transplant communication in SA has yet to be investigated, and this research was the first to use health communication technologies to collect empirical data related to it. In Gauteng Province, SA, To explore communication in transplant settings. SA To gather data across six hospitals and transplant centers in Gauteng, qualitative techniques were used. The importance of good practice and cohesive individual transplant teams was emphasized by the facilitators of interprofessional transplant cooperation. Recommendations for addressing some of the gaps include including integrating a health communications specialist into the transplant process, "knotworking," the use of apology, and a sophisticated warning text-message system for transplant professionals.

Source link: https://doi.org/10.7196/SAMJ.2017.v107i7.12355


Tolerogenic Dendritic Cells in Solid Organ Transplantation: Where Do We Stand?

Cell therapies have been shown as a novel promising tool to minimize the use of IS in transplantation at this time. Cell therapy's primary strength is its ability to breed allograft-specific immunity, which promotes in this way long-term allograft survival. Tolerogenic monocyte-derived dendritic cells appear to be a promising candidate for cell therapy due to their ability to produce specific antigen presentation and to polarize immune responses to immunotolerance. Both human Tol-MoDCs and rodent tolerogenic bone marrow-derived DCs are described in this study. Tol-MoDC is now used in the first phase I/II clinical trials in transplantation in addition to autoimmune disease clinical trials. In this study, the conversion of Tol-MoDCs to clinical use in transplantation will also be addressed.

Source link: https://doi.org/10.3389/fimmu.2018.00274


Perceived Barriers to and Facilitators of Physical Activity in Recipients of Solid Organ Transplantation, a Qualitative Study.

paraphrasedoutput:BACKGROUND: A key role for healthy organ transplant recipients is adequate physical fitness. The apparent barriers to and facilitators of physical fitness in this population are largely unknown. METHODS: In order to find out about actual barriers and facilitators, we conducted semi-structured in depth interviews with well-organ transplant recipients in order to investigate perceived barriers and facilitators. Personnel factors acting as a barrier or facilitator were self-efficacy and knowledge of employees. There was no agreement between transplant recipient groups, no overt differences were found. CONCLUSION: Several personal and environmental factors have been reported, and several environmental factors have been discussed in intervention design to raise physical fitness in healthy organ transplant recipients.

Source link: https://doi.org/10.1371/journal.pone.0162725

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions