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Open Angle Glaucoma - Springer Nature

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Last Updated: 21 July 2022

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Single Administration of Intracameral Bimatoprost Implant 10 µg in Patients with Open-Angle Glaucoma or Ocular Hypertension

terogrogucoma or ocular hypertension in adults with open-angle glaucoma or ocular hypertension was investigated by this report, lowering the sensitivity and safety of a single intracameral administration of bimatoprost implant 10 u00b5g in adults with open-angle glaucoma or ocular hypertension. A 24-month, phase 2 clinical trial compared one or two implants implanted in the study eye with once-daily topical bimatoprost 0. 03% in the comparison eye. Results in the 10-u00b5g bimatoprost implant and comparator treatment arms following a single implant delivery or rescue with IOP-lowering drugs were determined by separate analyses of the pooled phase 3 and phase 2 study findings, up to the time of implant re-administration or rescue with IOP-lowering drugs. No reports of corneal edema, corneal endothelial cell loss, or corneal touch were found in either research, and no patients had 20% or more loss in corneal endothelial cell density in each study after a single implant procedure, and no patients suffered from corneal endothelial cell loss, corneal endothelial cell loss, or corneal touch; no reports of corneal endothelial cell loss, or corneal touch, and corneal endo.

Source link: https://doi.org/10.1007/s40123-022-00527-6


Effect of prostaglandin analogues on the biomechanical corneal properties in patients with open-angle glaucoma and ocular hypertension measured with dynamic scheimpflug analyzer

Purpose of the Study The aim of the investigation is to investigate the effect of topical prostaglandin therapy on the corneal biomechanical characteristics in treatment-naefve patients with either primary open-angle glaucoma or ocular hypertension using the Corvis ST system. Using the most recent applications available, we analyzed the Corvis ST dynamic corneal response parameters of our database. Patients were compared at baseline and after 6 months of protaglandin analogue therapy. Results After six months of therapy, the IOP decrease values obtained with the various tonometers were u0394GAT 3. 7, 4. 3, 4. 1 btu00b1 5. 4, and 84. Conclusion The Corvis ST's SSI seems to have decreased dramatically following topical prostaglandin therapy. If GAT is used for IOP testing, we believe that our findings support the assertion that topical PG therapy does decrease corneal stiffness and, therefore, that the ocular hypotensive effect of these medications is exaggerated.

Source link: https://doi.org/10.1007/s00417-022-05752-0


Border tissue morphology is associated with the pattern of visual field progression in open-angle glaucoma

This investigation looked at potential risk factors, such as the morphology of the border tissue that influence eye field progression in eyes with OAG. At least in one direction, the eyes of 166 OAG patients with an externally oblique border tissue at least in one direction were included in a row. Using logistic regression analysis, the odds ratio of VF progression for each risk factor was estimated. In conclusion, the VF pattern in OAG eyes is related to the location of the longest EOBT as well as other known risk factors.

Source link: https://doi.org/10.1038/s41598-022-16186-3


Waardenburg syndrome type 4 coexisting with open-angle glaucoma: a case report

Waardenburg Syndrome is a disorder that has four main features. We review a case of Waardenburg syndrome type 4 in combination with open-angle glaucoma. Case report The 43-year-old Han Chinese man underwent trabeculectomy due to increased visual field impairment and uneven intraocular pressure in both eyes, as well as inconsistent intraocular pressure. A diffuse iris hypopigmentation in the left eye and hypopigmentation of a portion of the iris in the right eye were shown by a Slit-lamp examination. The normal portion of the iris showed a strong hyperreflective response of the anterior border layer, while the pigmented anterior border layer showed a hyporeflective region of the anterior layer, resulting in reduced light absorption. In this review, two mutations of the endothelin receptor type B gene were found. Conclusion Waardenburg syndrome has a remarkable degree of clinical appearance and morphology.

Source link: https://doi.org/10.1186/s13256-022-03460-1


iStent Trabecular Micro-bypass Stent Implantation Combined with Phacoemulsification for Open-Angle Glaucoma: A 2-Year Post-marketing Surveillance Study in Japan

Introduction We report two-year findings after the introduction of iStent stent with phacoemulsification in Japanese patients with mild to moderate open-angle glaucoma. Patients included adults with OAG on antiglaucoma drugs who had cataract surgery as well as one iStent implanted. Outcomes were collected in the general cohort and the glaucoma subtypes: primary OAG, normal-tension glaucoma, and exfoliative glaucoma. Mean u00b1 standard deviation IOP decreased from 17. 6 mmHg preoperatively to 14. 3 mmHg mean deviation IOP decreased from 17. 6 mmHg to 14. 3 mmHg, and the number of medications decreased from 2. 2 1. 2 preoperatively to 0. 8 1. 2 u00b1. At 24 months, there were 67. 6% medication-free eyes compared to 3. 2 percent medication-free eyes preoperatively. Conclusions Following iStent implantation in phacoemulsification, clinically relevant and statistically significant reductions in IOP and number of medications were found in Japanese eyes with OAG over 2 years, with favorable safety characteristics.

Source link: https://doi.org/10.1007/s12325-022-02207-0


CO_2 Laser-Assisted Sclerectomy Surgery Alone or Combined with Phacoemulsification in Primary Open-Angle Glaucoma: Comparison of 1-Year Outcomes

Introduction To compare the 1-year results of CO_2 laser-assisted sclerectomy surgery alone or combined with phacoemulsification in eyes with primary open-angle glaucoma. A total of 46 eyes with POAG underwent either CLASS or CLASS + Phaco were followed up for a year. BCVA's progress in the CLASS + Phaco group increased dramatically in BCVA, but there was no difference between BCVA before and after CLASS, but there was no difference in BCVA before and after CLASS. At 1 year after surgery, the overall success rate in the class was higher than the CLASS + Phaco group at 1 year. In a CLASS + Phaco group, the incidence of peripheral posterior synechiae was significantly lower than that of CLASS alone. Conclusion CLASS alone resulted in a greater IOP reduction, more common functional bleb formation, and a higher success rate than CLASS combined with Phaco, while combined with Phaco, resulting in a greater BCVA increase and a lower PAS incidence than CLASS alone.

Source link: https://doi.org/10.1007/s40123-022-00539-2


Comparative analysis of OCT-defined parapapillary beta and gamma zones between primary open angle glaucoma and primary angle closure glaucoma

The parapapillary atrophy ophthalmoscopic beta zone has been recently divided into a gamma zone and a beta zone based on OCT imaging. Primary open angle glaucoma and primary angle closure glaucoma were compared and compared the microstructural characteristics of parapapillary gamma and beta zones in order to determine the determining factors between primary open angle glaucoma and primary angle closure glaucoma. Seventy-three PACG patients with no evidence of an acute attack were excluded, while 78 POAG patients were enrolled. Patients were matched by propensity scores for age and visual field mean defect value, according to a matched by propensity scores for age and visual field mean defect rate. Compared to the PACG and POAG groups that adjusted for age and MD value, the gamma zone was larger and more prevalent in the POAG group, while the beta zone showed no significant difference. The size of parapapillary beta zone may be a more reliable predictor of glaucoma severity in eyes with PACG than in POAG.

Source link: https://doi.org/10.1038/s41598-022-15457-3


Combined phacoviscocanalostomy versus phacoemulsification alone in patients with coexisting cataract and mild-to-moderate open-angle glaucoma; a randomized-controlled trial

Background/Objective Management of concomitant cataract and glaucoma can be dependent on the stage of glaucoma and the patient's situation. In these patients, we aimed to compare the one-year results of phacoemulsification alone against phacoviscocanalostomy. We evaluated 89 patients with mild-to-moderate primary OAG or pseudoexfoliative glaucoma with visually significant age-related cataracts. The mean IOP dropped significantly in the phaco-visco group during the first and third months as compared to the phaco group, but it was not statistically significant at 6th and 12th months. Conclusions Although only phacoemulsification and phacoviscolostomy treatments can be used for patients with moderate to moderate OAG, we found higher success rates using phacoemulsification alone and phacoemulsification alone. Therefore, if the surgeon is an expert in this procedure, this non-penetrating surgery may be used in patients with visually impaired cataract and earlier stages of OAG, especially in patients with PEXG.

Source link: https://doi.org/10.1038/s41433-022-02152-w

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions