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Open Angle Glaucoma - DOAJ

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Last Updated: 21 July 2022

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An Agreement of Two Tonometers: Goldmann Applanation and Non-Contact Scheimflug Technology in Healthy, Ocular Hypertension and Open-angle Glaucoma Patients

Objective: In healthy, ocular hypertension, and primary open-angle glaucoma, Goldmann applanation tonometry and Corvis' goal was to find an agreement of intraocular pressure tested by Goldmann applanation tonometry and Corvis. GAT and Corvis' secondary aim was to find a consistency of intra-examiner and inter-examiner IOP testing. Methods: Fifty three eyes from 53 people were registered and divided into healthy, OHT, and POAG groups. Except one patient with only left eye eligible, only right eyes were selected for further statistical investigation, except one patient with only left eye eligibles. GAT and Corvis were randomly administered with the random sampling procedure. Measurement IOP fluctuation, five minutes and two minutes difference between measurements were strictly applied to Corvis and GAT respectively, but strictly applied for Corvis and GAT respectively. Per machine, the first ten patients's first 10 patients were administered three measurementr and two analyzers to determine intra-examiner and inter-examiner reliability. To determine the accuracy of the IOP measuring device, the Intraclass correlation coefficient was used. When comparing IOP between two measurers who used the same machine that demonstrated excellent inter-examiner fidelity, High ICCs were found. GAT tends to produce a higher IOP score, according to a GAT that provides higher IOP results. The highest mean difference and widest standard deviation could have occurred from poor communication between 2 machines, which could be due to poor communication. According to a Bland & Altman graph, the values were mixed, and no trend was found, suggesting that higher or lower average IOP would result in higher or lower difference between the two machines. Because of the poor relationship with the gold standard GAT-IOP, the use of Corvis-IOP in clinical practice is limited, especially in POAG patients.

Source link: https://doaj.org/article/493bfd3d2e8d4835bc6e1f1810489daf


Open-Label Extension Study Comparing Latanoprost 0.005% Without vs With Benzalkonium Chloride in Open-Angle Glaucoma or Ocular Hypertension

Patients: Patients who had previously completed a phase 3 noninferiority research were included in this phase three multicenter, open-label, nonrandomized, single group assignment. In the affected eye, patients self-administered 1 drop of latanoprost BAK-free nightly for 36 weeks. In all patients relative to baseline during the trial, Latanoprost BAK-free maintained lowered IOP for both the study and non-study eye. In 5 patients, clinically significant retinal or optic nerve changes were found. Ocular AEs occurred in 66 versus 74 patients on prior latanoprost BAK-free and reference, respectively; the most common complaints were eye pain and ocular hyperemia.

Source link: https://doaj.org/article/e4fa3dccfe7f4355b9144831fd38f5cf


Correlation between Heidelberg Retinal Tomography (HRT II) Parameters and Visual Field Indices in Primary Open Angle Glaucoma Patients

Until now, there had been no correlation between the perimetry and HRT measurements in Caucasian eyes. Mission: To compare the HRT parameters and visual field indices in Indian eyes, including established glaucoma and glaucoma suspect patients. The correlations between global parameters measured by HRT and global visual field indices were discovered to be significant for rim area, rim volume, height variation contour, mean RNFL thickness, and the finding of RNFL cross sectional area. Conclusion: With the highest correlation coefficient of 0. 32, there was a good correlation between global visual field indices and HRT II parameters. Since we had multiple parameters relating to glaucoma in early glaucomatous damage, HRT II is as sensitive as perimetry and HRT II can be a useful tool in analysis and diagnosis of glaucoma.

Source link: https://doi.org/10.4103/2321-7006.301928


Border tissue morphology is associated with the pattern of visual field progression in open-angle glaucoma

This research looked at potential risk factors, such as the morphology of the border tissue, which could influence the pattern of visual field transition in eyes with OAG. At least in one direction, 166 eyes of 166 OAG patients with an externally oblique border tissue at least in one direction were included. Each point in the VF was used to determine VF progression by using a pointwise linear regression method to determine VF progression by determining each point in the VF. In conclusion, the VF change pattern in OAG eyes is correlated with the location of the longest EOBT as well as other common risk factors.

Source link: https://doi.org/10.1038/s41598-022-16186-3


Waardenburg syndrome type 4 coexisting with open-angle glaucoma: a case report

There are four forms of Waardenburg syndrome with differing symptoms. Herein, we describe a case of Waardenburg syndrome type 4 mixed with open-angle glaucoma. Case description A 43-year-old Han Chinese man had undergone trabeculectomy due to visual field impairment progression and unstable intraocular pressure in both eyes, and case presentation. A diffuse iris hypopigmentation in the left eye and hypopigmentation of a portion of the iris in the right eye were found in the iris hypopigmentation. The normal portion of the iris showed a clear hyperreflective signature of the anterior border layer, while the darker anterior border layer showed a thinned anterior border layer, resulting in reduced light absorption. In this research, two new mutations of the endothelin receptor type B gene were identified. At codon 185, the other mutation results in a amino acid change from vaping to methionine.

Source link: https://doi.org/10.1186/s13256-022-03460-1


Depicting Developing Trend and Core Knowledge of Primary Open-Angle Glaucoma: A Bibliometric and Visualized Analysis

Objection The prevalence of glaucoma is on the rise due to an aging population. Metadata from 2000 to 2021 in the Web of Science database were collected and analyzed by bibliometrics, assessing primary open angle glaucoma, the most common type of glaucoma, to determine its present status, global trend, and state of clinical research. The Journal of Glaucoma has published the most papers and had the most citations, as well as the most citations, while the Journal of Glaucoma has published the most papers on this topic. Many areas of research have been explored, from epidemiology to pathogenesis and diagnosis, then to therapy. Conclusion: Studies on primary open angle glaucoma go beyond epidemiology and epidemiology, to biochemistry molecular biology, general internal medicine, pharmacy, science technology, and other areas have spanned the globe. Primary open angle glaucoma is on the rise, with increasing interest, study, and publications on the subject.

Source link: https://doi.org/10.3389/fmed.2022.922527


Patients with Retinitis Pigmentosa May Have a Higher Risk of Developing Open-Angle Glaucoma

The similarities in genetic variations and pathophysiology between RP and OAG have been documented. We wanted to know if patients with RP had a significantly elevated risk of OAG formation. We recruited patients with RP into the RP group through Taiwan's National Health Insurance Research Database from 2001 to 2013; we also included a comparison group of 1 : 4 age-and-gender individuals without RP among the population without RP. The cumulative incidence of OAG in patients with RP was 1. 7%, significantly higher than that in the comparison group. The risk of OAG growth in the RP group was significantly higher than in the comparison group, which had unadjusted HR of 2. 86 percent. According to this national population-based cohort analysis, people with a RP are at a significantly higher risk of experiencing OAG than those without it.

Source link: https://doi.org/10.1155/2022/9719095


Bioinformatic Prioritization and Functional Annotation of GWAS-Based Candidate Genes for Primary Open-Angle Glaucoma

Background: Primary open-angle glaucoma is the most common glaucoma subtype, but its precise etiology is uncertain. We sought to prioritize the most likely u2018causalu2019 genes and determine functional characteristics and underlying biological pathways of POAG candidate genes in this research. Methods: We used the results of a large POAG genome-wide association analysis report from GERA and UK Biobank cohorts to analyze gene expression in a large POAG genome-wide association analysis research. To find overrepresented functional pathways and tissues, we next performed functional enrichment studies. Gene expression priorities in cellular tissue like sclera and trabecular meshwork showed enhancement in prioritized gene expression. POAG's pleiotropy with intraocular pressure and optical-disc measurements, as well as genetic correlation with hypertension and diabetes-related eye disease were found by researchers. Conclusions: Our results support a greater understanding of the biological mechanisms responsible for glaucoma pathogenesis, and have prioritized several novel candidate genes for functional follow-up studies.

Source link: https://doi.org/10.3390/genes13061055


Modified suture-assisted canaloplasty in Asians with primary open-angle glaucoma: a prospective study with 12-month follow-up

Abstract Background: In Asians with primary open-angle glaucoma, modified suture-assisted canaloplasty evaluates the efficacy and safety of suture-assisted canaloplasty. Methods An Asian POAG patient was treated with a prospective, consecutive cases study, evaluating a modified canaloplasty by twisting 6/0 suture. Within 5/0, twisted 6/0 polypropylene sutures, and the microcatheter, the twisted 6/0 suture was chosen as a probe based on characteristical analysis of size and contact measurement, as well as chemical analysis conducted in 5/0, twisted 6/0 polypropylene sutures, and the microcatheter. Forty eyes from 40 consecutive patients were included in a mean follow-up of 14. 8 u00b1 3. 0 months, with a mean follow-up of 14. 8 u00b1 3. 0 months. Mean IOP went from 26. 2 mmHg to 14. 5 mmHg at 12 months postoperatively, meaning IOP fell from 26. 2 u00b1 6. 9 mmHg to 14. 5 mmHg. Conclusion Twisted 6/0 suture can be a good material for cannulation. Trial registration This trial was approved in the Chinese Clinical Trial Registry, according to the Chinese Clinical Trial Registry.

Source link: https://doi.org/10.1186/s12886-022-02424-9


Waveform changes of laser speckle flowgraphy in the temporal optic nerve head and peripapillary atrophy after trabeculectomy in open-angle glaucoma

After trabeculectomy, a prospective study was conducted on 33 eyes of 33 patients with open-angle glaucoma who underwent trabeculectomy to examine hemodynamic changes in the temporal optic nerve head and peripapillary atrophy. MT in the ONH and u03b3PPA regions remained unchanged at all time points, while those in the ONH and u03b3PPA regions remained unchanged. Despite regional differences between the regions, IOP decrease-associated BOS rise in all regions occurred postoperatively, indicating that IOP reduction might reduce vascular pressure and aid in steady blood flow uniformly.

Source link: https://doi.org/10.1038/s41598-022-13989-2

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions