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Open Angle Glaucoma - Crossref

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Last Updated: 21 June 2022

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Adult-Onset Primary Open Angle Glaucoma Does Not Localize to Chromosome 2cen-q13 in North American Families

Glaucoma is one of the world's most common causes of irreversible blindness, and it is characterized by elevated intraocular pressure, optic nerve atrophy, and progressive visual field loss. Primary open angle glaucoma is the most common form of glaucoma in the United States. Recently, Stoilova and coworkers [Genomics 1996:36:142, u2013150] established a locus for POAG on chromosome 2 in families primarily located in the United Kingdom. We investigated families with POAG names in the United States for connection to the 2cen-q13 locus. These findings reveal that the chromosome 2cen-q13 locus does not account for a substantial amount of genetic variation in familial POAG.

Source link: https://doi.org/10.1159/000022812


Ocular Tolerability of Bimatoprost 0.1 mg/mL Preservative-Free versus Bimatoprost 0.1 mg/mL with Benzalkonium Chloride or Bimatoprost 0.3 mg/mL Preservative-Free in Patients with Primary Open-Angle Glaucoma

This research sought to see if the conversion from a Bimatoprost 0. 1 mg/mL preservative-free to a Bimatoprost 0. 1 mg/mL preservative-free formulation could lead to improved eye surface conditions in patients with glaucoma; intraocular pressure was also assessed. Both Bimatoprost 0. 1 mg/mL preservative-free at 14 and 28 days were measured, revealing significant differences in OSDI and BUT between BAK and Bimatoprost 0. 1 mg/mL at baseline vs. Bimatoprost 0. 1 mg/mL preservative-free at 14 and 28 days were observed between BAK and BUT. Both at baseline and after 28 days, there were significant differences in OSDI and BUT among Bimatoprost 0. 3 mg/mL preservative-free at baseline and Bimatoprost 0. 1 mg/mL preservative-free at 14 and 28 days.

Source link: https://doi.org/10.3390/jcm11123518


The structure of human retinal vasculature and interstitium in the terminal stage of primary openangle glaucoma

Purpose: To investigate the vascular bed of human retina in the vascular bed of primary open-angle glaucoma in the terminal phase. Using the endothelium CD34 markers, we carried out a comparative immunohistochemical investigation of vessels in the retina of 13 eyes of patients in the terminal stage of POAG, enucleated for medical reasons, and 17 eyes with uveal melanoma. Patients in the terminal stage of POAG's retina were shown a significant increase in the volume density of the interstitium and a decrease in the volume density of CD34+-blood vessels in the retina of patients in the terminal stage of POAG, as well as uveal melanoma. The increased volume density of luminal and basal caveolae, as well as the emergence of transendothelial channels in blood capillary endotheliocytes' cytoplasm indicate transcytosis and the blood-retinal barrier's permeability.

Source link: https://doi.org/10.21516/2072-0076-2022-15-2-supplement-121-128


Combined surgery for cataract and open-angle glaucoma by a modified technique of partially fistulizing surgery

Comparing the medical and surgical outcomes of a combined intervention of one-stage cataract phacoemulsification and a newly developed version of partially fistulizing antiglaucoma surgery of patients with primary open-angle glaucoma surgery in comparison to those of phacoemulsification in combination with penetrating and non-penetrating antiglaucoma treatment, according to the comparison. Patients with a combination of incompletely comprehensible cataract and previously unoperated stages Iu2013III POAG. Patients were divided into three groups, group 1 with ultrasonic cataract phacoemulsification and non-penetrating deep sclerectomy; two groups 2 control, 25 patients, 28 eyes patients with PEC and trabeculectomy; and group 3 with PEC and the newly formed PFS; and group 3 with PEC and the newly formed PFS. In both the main group and the control group 1, the best visual results over the relevant period were recorded over the same period.

Source link: https://doi.org/10.21516/2072-0076-2022-15-2-supplement-31-37


Evaluation of morphometric parameters of the optic disc in patients with diverse clinical forms of openangle glaucoma

To determine the thickness of the prelaminar layer of nerve fibers and the depth of the lamina cribrosa in patients with several forms of open-angle glaucoma, measured by optical coherence tomography. Patients aged 71. 4 – 8. 7 with stage II glaucoma were divided into three groups based on the severity of glaucoma, including group 1 of 39 patients with primary openangle glaucoma; group 2 of 26 patients with primary openangle glaucoma; group 3 of 22 patients with pseudoexfoliative glaucoma; group 2 of 39 patients with stage II glaucoma. In the OCT Disk + Macula 3D regimen and the Disk Raster regimen Optopol Revo 60 OCT device, all patients were tested for the optic disc and macular areas, as well as the Disk + Macula 3D regiment and the Macular areas. No significant differences were discovered between the LC depth in patients with various types of glaucoma compared to the control group.

Source link: https://doi.org/10.21516/2072-0076-2022-15-2-supplement-24-30


Dietary Nitrate Intake Is Associated with Decreased Incidence of Open-Angle Glaucoma: The Rotterdam Study

Previous research shows that nitric oxide is involved in the regulation of the intraocular pressure and in the pathophysiology of open-angle glaucoma. However, prospective studies examining the relationship between dietary nitrate intake, a source of nitric oxide, and incident OAG risk are limited. We wanted to see if there was a correlation between dietary nitrate intake and iOAG, as well as investigate the relationship between dietary nitrate intake and IOP. Both nitrate and nitrate intakes from non-vegetable food sources were associated with a reduced iOAG risk. Dietary nitrate intake was not connected with IOP, not connected to IOP.

Source link: https://doi.org/10.3390/nu14122490


Analysis of the trabecular pigmentation in patients with primary open-angle glaucoma using the colorimetric scale

In patients with primary open-angle glaucoma, the development of a photocolorimetric scale to determine the presence of trabecula pigmentation along its circumference. Primary open-angle glaucoma was found in 36 patients. We did colorimetric analysis of the iridocorneal angle pigmentation at 360 u00b0 using the Pixelmator Pro and the photographic images. Using the Nidek GS-1 gonioscope, photochrometric measurement of trabecular pigmentation along the circumference of the iridocorneal angle in patients with primary open angle glaucoma was possible. Patients with glaucoma are able to determine with high accuracy the differences between the levels of trabecular pigmentation in patients with glaucoma. Using a photocolorimetric scale helps to determine objectively the effectiveness of laser procedures aimed at lowering the degree of trabecular pigmentation along the entire circumference of the iridocorneal angle.

Source link: https://doi.org/10.25276/2312-4911-2022-3-163-168


Features of local hypotensive therapy in patients with primary open-angle glaucoma

A retrospective review of the administration of local antihypertensive drugs to patients with primary open u2013 angle glaucoma was conducted to determine the effectiveness of local antihypertensive therapy. There was a significant decrease by 18. 4 percent in the number of people who were prescribed monotherapy in the dynamic sequel to patients with glaucoma, as well as a notable rise by 19. 2 % in the number of people who received combination therapy, with a dramatic decline by 19. 4 percent. Keywords: primary open-angle glaucoma, drug therapy, eye drops, in 76. 6 percent of cases with POAG II st. , in 57. 3 % with POAG III st. , and in 47. 1 percent with POAG IV st. , in 57. 3 % with POAG III st. , with 56. 6 % with POAG II st. , in 56. 6 % with POAG III st. , and in 47. 1 st.

Source link: https://doi.org/10.25276/2312-4911-2022-3-50-55


Bioinformatic Prioritization and Functional Annotation of GWAS-Based Candidate Genes for Primary Open-Angle Glaucoma

The most common glaucoma subtype is primary open-angle glaucoma, but the exact cause is uncertain. We sought to prioritize the most likely u2019u2019 genes to identify functional characteristics and underlying biological pathways of POAG candidate genes in this research. Methods: We used the results of a large POAG genome-wide association analysis study from GERA and UK Biobank cohorts to analyze their results. Next, we did functional enrichment studies to find overrepresented functional pathways and tissues. Prioritized gene expression was shown by ocular tissues, sclera and trabecular meshwork, which highlighted enrichment in prioritized gene expression. We found pleiotropy of POAG with intraocular pressure and optical-disc measurements, as well as genetic correlations with hypertension and diabetes-related eye disease in our research. Conclusions: Our findings contribute to a greater understanding of the molecular mechanisms involved in glaucoma pathogenesis, and we've prioritized many novel candidate genes for functional follow-up studies.

Source link: https://doi.org/10.3390/genes13061055


Deep Sclerectomy in Primary Open-Angle Glaucoma and Exfoliative Glaucoma

Purpose: In primary open-angle glaucoma and exfoliative glaucoma, the purpose is to investigate the effects of deep sclerectomy. In a Cox regression model, we investigated several factors relating to the outcome of surgery. Results in the POAG group The mean IOP decreased from 22. 6 mm Hg preoperatively to 16. 8 mm Hg, with qualified success in 70% of eyes. IOP went from 25. 5 mm Hg preoperatively to 16. 5 mm Hg postoperatively, in 66% of eyes, with qualified success achieving in 66% of eyes. 1 week IOP between 2 and 14 mm Hg without medication reduced the chance of achieving complete success by 44%, while the hazard rate of losing qualified candidates by 54% was 54%. Conclusions The IOP 1 week postoperatively seems to be a good measure of surgical success. Deep sclerectomy is cost-effective in lowering IOP in the POAG and EXG subgroups, with reoperations more common in EXG eyes.

Source link: https://doi.org/10.5301/ejo.5000762

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions