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Purpose of the Paper Purpose The results of subthreshold micropulse laser trabeculoplasty in a series of patients affected by primary open angle glaucoma are published here. Eye-drops in use were used at baseline and in each consultation after MLT, providing evidence on IOP, best corrected visual acuity, local and systemic side effects, and various other critical variables. Mean baseline IOP was 18. 4 mmHg with 1. 43 u00b1 0. 85 glaucoma drugs at 57. 68 u00b1 8. 0 years, with mean baseline IOP of 18. 4 mmHg, and median age of 4. 8 years was 8. 68 u00b1 8. 0 years. MLT treatment resulted in significantly lower IOP at both 1 month and 24 months compared to baseline. No statistically significant difference was found between IOP at 1 month and 12 months, and between IOP at 1 month and at 12 months after treatment, with the IOP around 1 month and 24 months later. During or after MLT, no local or systemic side effects were recorded. MLT in POAG's first prospective research is the first prospective study to determine long-term effects of MLT in POAG.
Source link: https://doi.org/10.21203/rs.3.rs-1750450/v1
The effect of dosed endobronectomy in combination with non-penetrating deep sclerectomy on the level of intratocular pressure and aqueous humor outflow from the anterior chamber can be determined. The study involved 12 patients who underwent dosed endotrabeculectomy with an ab interno approach in conjunction with non-penetrating deep sclerectomy surgery. According to Maklakov, measurement of IOP was done before and after surgery. IOP was lower in the 6th month after surgery, and the IOP dropped to 8. 67 mm Hg in the 12th month, with 7. 83 mm Hg lower. The outflow facility coefficient was much improved from 0. 14 mm3/min to 0. 32 mm3/min, up from 0. 15 mm3/min to 0. 32 mm3/min. In patients with primary open-angle glaucoma and non-penetrating deep sclerectomy in combination with non-penetrating deep sclerectomy have all shown the significant hypotensive effect, as well as the rise in outflow facility coefficient and the decrease in Becker's coefficient during the postoperative period.
Source link: https://doi.org/10.14739/2310-1210.2022.3.246307
At a six-month follow-up, we review the surgical results and early complications involved with their care of the Preserflo MicroShunt. When analyzing all patients, BCVA is significantly higher one day after the surgery than before the therapy. When analyzing only patients treated with MMC 0. 2 or 0. 5 mg/mL, such dependency is not present. Overall IOP is significantly lower at any time point after treatment than before surgery. The IOP level among patients treated with MMC 0. 2 mg/mL is also lower at every time point after treatment than before treatment. Patients with MMC = 0. 4 percent u2014 The IOP level is much lower at any time point after treatment than before therapy. Early findings reveal that Preserflo MicroShunt is safe and effective at lowering IOP; however, it is not free from transient issues.
Source link: https://doi.org/10.3390/ijerph19148679
We investigated the mechanism of Qing-Gan Li-Shui's use in treating primary open glaucoma by network pharmacology and in vitro experiments in this research. The active pharmaceutical ingredients of GLQSF were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, as well as another traditional Chinese Medicine database. STRING online plotted a protein-protein network. Finally, the benefits of APIs were demonstrated by a model of chloride hexahydrate-induced retinal ganglion cells-5. Nine clusters of QGLSF targets were found by the PPI network analysis, including AKT-1, TP53, and JUN. As shown by RT-PCR, the mRNA levels of AKT-1, TP53, JUN, and RAGE decreased. To combat POAG, the QGLSF may use the age-RAGE signaling pathway to counter POAG. This report preliminarily clarifies the role and mechanism of QGLSF in the treatment of POAG.
Source link: https://doi.org/10.1155/2022/8336131
In patients with open-angle glaucoma or ocular hypertension, the aim of this review was to demonstrate the equivalence of generic dorzolamide 2% eye drops therapy versus the innovator's formulation. Patients were randomized to a reference product or test kit for a 4-week period after washing out. Therapy compliance was demonstrated by self-reporting and weighing bottle weighing. An ANOVA with medicine, sequence, study period, and patient within the sequence as effects were administered and an additional post hoc ANCOVA including baseline IOP was also performed. The 90 percent confidence interval for the average change of the IOP 20120. 27 mmHg is included in the acceptance range u22121. 5 mmHg to +1. 5 mmHg, which had mistakenly posted high therapy adherence under the ANCOVA scheme. This report demonstrated the equivalence of the tested generic dorzolamide 2% eye drops solution to the reference product Trusoptu00ae eye drops solution.
Source link: https://doi.org/10.1155/2022/5249922
According to glaucoma severity, this research was designed to determine the rate of thinning between retinal nerve fiber layer thickness and Bruchu2019s membrane opening minimum rim width in open-angle glaucoma. Thinching was the fastest in the high-end medical field and the superotemporal sector of the other two groups. Thinching in the inferotemporal sector in the BMO-MRW group made no difference, but in the medium MD and low MD groups, it was quicker than in the high MD group. In the inferotemporal sector, the fastest rate of RNFLT thinning was consistently observed, but BMO-MRW announced a change in the fastest thinning market, from inferotemporal to superotemporal, with increasing severity in early to moderate OAG.
Source link: https://doi.org/10.21203/rs.3.rs-1838147/v1
Objective: To determine the progression of primary open-angle glaucoma and serum cytokine IL-6 and IL-10 ratios as biomarkers for diagnosis of primary open-angle glaucoma. Methods: 20 POAG patients and 21 healthy people from the Indonesian community were included in this research. The serum concentrations of IL-6 and IL-10 were determined. POAG patients had a higher IL-6 and IL-10 ratio than controls, with a higher IL-6 and IL-10 ratio than controls. Among the POAG patients, advanced-stage patients had a higher IL-6/IL-10 ratio than those in the early-moderate stage. Conclusion: The resulting mash-up of IL-6 and IL-10 serum levels can be very helpful in discriminating POAG severity.
Source link: https://doi.org/10.1177/11206721211037133
Purpose: Mutations in the CYP1B1 gene have played a role in primary open angle glaucoma pathogenesis, according to the current genetic association studies, but contradictory findings were published. Methods An comprehensive review of studies that correlated the risk of carrying CYP1B1 gene polymorphisms with POAG formation was carried out. In our meta-analyses, we included 19 case-control studies, including 3855 POAG patients and 4125 control subjects. POAG patients were more frequent than those in all controls.
Source link: https://doi.org/10.1177/11206721221077621
Purpose: To discuss a new discovery of TGFBI variants with congenital glaucoma in a family with GAPO syndrome, as well as in other Juvenile onset open angle glaucoma cases, as well as the mechanistic effects of the protein variants. Methods: This review of one family of GAPO with congenital glaucoma and three unrelated patients of JOAG explored a common link to glaucoma pathogenesis. We present the physical characteristics of three girls with GAPO syndrome born of consanguineous marriage in a multi-generation consanguineous family. In the two siblings with congenital glaucoma and GAPO syndrome, a rare missense variant of the TGFBI gene was present. We also discovered three other unrelated patients with JOAG without known glaucoma causing gene mutations but with three distinct TGFBI gene variants.
Source link: https://doi.org/10.22541/au.165812674.48680553/v1
Primary open-angle glaucoma is a progressive optic neuropathy with retinal ganglion cells destruction and narrowing of the eye's viewing fields with a gonioscopic open angle. However, concerns regarding the role of POAG genetic predisposition remain unveiled. Objective: a review of existing research on the mechanisms of progressive neuropathy in POAG and the role of genetic predisposition. Around 60 million glaucoma patients in the world, 20% of whom have an incurable disease. Prolonged inflammation process leads to hypersecretion of inflammatory mediators and infiltration of inflammatory cells into ischemic tissue, exacerbating the effects of elevated IOP and ischemia. In different ethnic groups, a promising direction is to investigate the role of TLR4 mutations to the POAG genes, which will reveal immune disorders and determine the genetic risk of individual mutations.
Source link: https://doi.org/10.32345/2664-4738.2.2022.11
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