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Oophorectomy - PubMed

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Last Updated: 06 January 2023

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Prophylactic oophorectomy and aromatase inhibitors for premenopausal deep angiomyxoma: A case report and literature review.

Deep angiomyxoma is a rare, infiltrative, hormone-dependent, benign-mesenchymal neoplasm that occurs in the deep soft tissues of the perineal zones. In total, 33% females with newly diagnosed deep angiomyxoma will relapse within five years after the recommended treatment of radical resection. Prophylactic oophorectomy in premenopausal women is often used to prevent recurrence, but the role of prophylactic oophorectomy in premenopausal women has yet to be fully understood. Prophylactic oophorectomy and postoperative adjuvant therapy with aromatase inhibitors may be a promising treatment strategy for deep angiomyxoma to optimize surgical treatment's success.

Source link: https://doi.org/10.3892/etm.2022.11702


Aromatase-Inhibitor-Induced Musculoskeletal Inflammation Is Observed Independent of Oophorectomy in a Novel Mouse Model.

Female BALB/C-Xen mice, which have a firefly luciferase reporter gene, were oophorectomized and treated with an AI. With AI treatment in the hind limbs, bioluminescent imaging enhanced NFu03baB activation significantly. In addition, an investigation of the knee joints and legs by MRI revealed enhanced signal detection in the joint space and the surrounding tissue. The responses observed with AI therapy were not related to oophorectomy, suggesting that inflammation is not mediated by physiological estrogen levels rather than physiological testosterone levels. Human PBMCs treated with letrozole/estrogen combinations did not have an AI-specific gene expression pattern, suggesting AIIA-mediated pathogenesis in other cell types. These findings, collectively, show an AI-induced rise in disease pathology and suggest that AI-induced pathogenesis may not be mediated by estrogen deficiency, as previously predicted.

Source link: https://doi.org/10.3390/ph15121578


Risk-Reducing Salpingo-Oophorectomy (RRSO) Combined with Simultaneous Mastectomy in Women with BRCA 1-2 Mutation Carriers: The Surgical Technique, the Feasibility and Patients' Satisfaction of Multiple Surgeries.

In patients with BRCA 1-2 mutation carriers, the main aim of our study was to determine the surgical technique, the safety, and patient satisfaction of many surgeries. BRCA 1-2 variants of breast cancer survivors who underwent RRSO combined with risk-reducing bilateral mastectomy or breast cancer surgery from January-2015 to December-2021 was analyzed in a retrospective study. Forty-eight patients underwent RRSO, and six patients underwent RRSO + Total laparoscopic hysterectomy. One breast seromas aspiration, one infectious reconstructive disease treated with antibiotics therapy, one Red-Breast-Syndrome, and one trocar abdominal hematoma associated with RRSO were all four major postoperative complications within 30 days. Five days in a row were five: two evacuations of a breast hematoma and three infectious reconstructive disorders treated with expander/implant removal. According to the satisfaction survey, more than 80% of patients were satisfied and that they would have combined surgery once more.

Source link: https://doi.org/10.3390/jcm11247502

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions