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Oophorectomy - Europe PMC

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Last Updated: 06 January 2023

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Risk-Reducing Salpingo-Oophorectomy (RRSO) Combined with Simultaneous Mastectomy in Women with BRCA 1-2 Mutation Carriers: The Surgical Technique, the Feasibility and Patients' Satisfaction of Multiple Surgeries.

In patients with BRCA 1-2 mutation carriers, the primary aim of our study was to investigate the surgical technique, the safety, and patient satisfaction of multiple surgeries: risk-reducing salpingo-oophorectomy with mastectomy in patients with BRCA 1-2 mutation carriers. Patients with BRCA 1-2 variants who underwent RRSO combined with risk-reducing bilateral mastectomy or breast cancer surgery from January-2015 to December-2021 were followed retrospectively by a retrospective review of patients with BRCA 1-2 variants who underwent RRSO combined with risk-reducing bilateral mastectomy or breast cancer from January-2015 to December-2021. Six patients underwent RRSO, and six others underwent RRSO + Total laparoscopic hysterectomy. One breast seromas aspiration, one infectious reconstructive syndrome treated with antibiotics therapy, one Red-Breast-Syndrome, and one trocar abdominal hematoma associated with RRSO were all within 30 days. Two evacuations of a breast hematoma and three infectious reconstructive disorders treated with expander/implant implantation were the major postoperative complications within 30 days. According to the satisfaction survey, more than 90% of patients were happy and that combined surgery will be performed again.

Source link: https://europepmc.org/article/MED/36556118


Aromatase-Inhibitor-Induced Musculoskeletal Inflammation Is Observed Independent of Oophorectomy in a Novel Mouse Model.

In patients with hormone-receptor-positive breast cancer, aromatase Inhibitors block estrogen production and improve survival. Female BALB/C-Xen mice, which have a firefly luciferase reporter gene, were oophorectomized and treated with an AI. With AI therapy in the hind limbs, bioluminescent imaging showed significant elevation in NFu03baB activation with AI treatment. In addition, an investigation of the knee joints and legs using MRI revealed improved signal detection in the joint space and the surrounding tissue. The reactions observed with AI therapy were remarkably independent of oophorectomy, showing that inflammation is not mediated by hormonal estrogen levels rather than by physiological estrogen levels. Human PBMCs treated with letrozole/estrogen combinations did not have an AI-specific gene expression pattern, suggesting AI-mediated pathogenesis in other cell types. These results reveal an AI-induced rise in disease pathology and indicate that AI-induced disease pathology does not arise from estrogen deficiency, as previously assumed.

Source link: https://europepmc.org/article/MED/36559029

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions