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We wanted to investigate the relationship between hysterectomy or bilateral salpingo-oophorectomy, as well as the risk of subsequent thyroid cancer. According to the extent of surgery, the surgical group was divided into two groups: hysterectomy with ovarian conservation and BSO with or without hysterectomy. Compared to those in the no surgery group, women in the hysterectomy-only and BSO groups had an elevated risk of thyroid cancer. Unlike hormone therapy, there was no significant correlation between hysterectomy-only or BSO in postmenopausal women who had undergone hormone therapy. Conclusions: Our results do not support the hypothesis that estrogen levels, whether sudden or early decline in estrogen levels is a risk factor for thyroid cancer development, or that exogenous estrogen is a risk factor for thyroid cancer.
Source link: https://doi.org/10.1530/eje-20-0686
In patients with metastasising breast tumors, the depletion of oestrogen excretion caused by oophorectomy infused with cortisone therapy was investigated. Patients with disseminating breast cancer excreted substantial amounts of oestriol in comparison to healthy women of the same age, whether preor postmenopausal or prenatal. Both oestrone and oestradiol-17b2 excretion were similar in cancer patients and healthy women of corresponding age. Not only in premenopausal cases but also in a number of postmenopausal patients, particularly those who were already exorbiting significant amounts of oestrogens, but also in those who were still excusing significant amounts of oestrogens. Oophorectomy, coupled with adequate cortisone therapy, seems to be a back-to-the-invasive surgical procedures used to reduce oestrogen production in breast cancer patients.
Source link: https://doi.org/10.1530/acta.0.0470015
However, there are practically no studies examining the effects of OvX on breast tumour biology. We therefore, characterized OvX's endocrine and genome-wide transcriptional effects in 56 premenopausal women with ER + breast cancer for two weeks before mastectomy. Plasma estradiol concentrations decreased from 406 mb1 to 20. 7 pmol/l 24 h after OvX, and to 8. 1 0. 8 pmol/l 2 weeks later at mastectomy, decreasing from 406 u00b1 41 to 20. 7 pmol/l 2 weeks later. The gene expression changes did not differ according to HER2 status, and they closely followed the changes reported earlier after aromatase inhibitor therapy in postmenopausal women. In conclusion, tumour gene expression after OvX were largely similar, but of a larger extent than those observed after AI in postmenopausal patients; however, OvX seemed to have a greater effect on progesterone-regulated genes than AI.
Source link: https://doi.org/10.1038/s41523-017-0049-z
Aromatase Inhibitors inhibit estrogen production and improve survival in patients with hormone-receptor-positive breast cancer. Female BALB/C-Xen mice, which have a firefly luciferase reporter gene, were oophorectomized and treated with an AI. With AI treatment in the hind limbs, bioluminescent imaging showed substantial rise in NFu03baB activation. Moreover, an analysis of the knee joints and legs by MRI revealed enhanced signal detection in the joint space and the surrounding tissue. The reactions observed with AI therapy were surprisingly independent of oophorectomy, suggesting that inflammation is not mediated by physiological estrogen levels, not mediated by physiological estrogen levels. Human PBMCs treated with letrozole/estrogen combinations did not have an AI-specific gene expression pattern, suggesting AI-mediated pathogenesis by other cell types. These results, taken collectively, reveal an AI-related rise in disease pathology and suggest that AI-induced disease pathology can not be mediated by estrogen deficiency, as previously predicted.
Source link: https://doi.org/10.3390/ph15121578
The primary aim of our investigation was to determine the surgical procedure, the safety, and patient satisfaction of multiple surgeries: Risk-reducing salpingo-oophorectomy combined with mastectomy in patients with BRCA 1u20132 mutation carriers. From January-2015 to December-2021, we conducted a retrospective review of patients with BRCA 1u20132 variants who underwent RRSO combined with risk-reducing bilateral mastectomy or breast cancer surgery. Six patients underwent RRSO, and six others underwent RRSO + Total laparoscopic hysterectomy. Three seromas aspiration, one infectious reconstructive syndrome treated with antibiotics, one red-Breast-Syndrome, and one trocar abdominal hematoma associated with RRSO were all within 30 days. Five major postoperative complications were contained within 30 days, including two evacuations of a breast hematoma and three infectious reconstructive disorders treated with expansion expander/implant. More than 80% of patients were happy and will have combined surgery again, according to the satisfaction questionnaire.
Source link: https://doi.org/10.3390/jcm11247502
After bilateral oophorectomy and luteectomy, pregnancy proceeded well, and the serum levels of oestrogens and progesterone were similar to those in intact monkeys, but progesterone levels were still low, although progesterone levels were relatively low after parturition. During dexamethasone injections into intact and oophorectomized pregnant monkeys, there were abrupt and dramatic decreases in total oestrogens, oestrone, and oestradiol levels, but no significant changes were observed in plasma progesterone levels. These results show the relative influence of the ovaries, adrenals, and placenta on maternal plasma levels of oestrogens and progesterone in the pregnant rhesus monkey.
Source link: https://doi.org/10.1530/acta.0.0750601
In one-third of females with anti-N methyl-D-aspartate receptor encephalitis, an anti-N -methyl-D-aspartate receptor encephalitis has been present in one-third of females with enzymatic encephalitis. If a teratoma is detected on imaging, its removal is first-line therapy. And despite numerous imaging techniques, occasionally, the teratoma is found only on subsequent imaging, long after initial presentation. We have a patient in whom teratoma removal, which is not apparent on conventional imaging, resulted in significant clinical improvement. Patients are often females of childbearing age and who at the time lack the skills to make medical decisions, which makes this decision even more difficult.
Source link: https://doi.org/10.1136/practneurol-2020-002676
The article describes a clinical investigation into a patient with primary infertility despite morbid obesity and massive cystic teratoma of the right ovary, who underwent bariatric surgery u2013 laparoscopic right-sided oophorectomy. The use of many infertility treatment options in obese women is ineffective, and pregnancy results are often disappointing. Bariatric surgery is the only proven effective treatment for morbid obesity. However, the polyetiological constituency of primary infertility in women, rather than uterine, dictates the need for a multi-layered approach to therapy. U2013 was the target achieved u2013 After ten months, the patient was diagnosed with a progressive uterine pregnancy for a period of 11 weeks, with a decrease in body weight by 49. 9% of overweight. The patient began to shed body weight after the birth of the baby, and 29 months after surgery, she gained 67% of her excess weight.
Source link: https://doi.org/10.21518/1995-1477-2022-19-2-134-140
Background: Little is known about the long-term risks of stroke and ischemic heart disease in women who had a hysterectomy alone or with bilateral oophorectomy for benign diseases, particularly in China, where the burden of cardiovascular disease is high. In Chinese women who had a HA or HBO, we estimated mean values of cardiovascular risk factors and relative risks of stroke and IHD. Women with HA and 19% higher risk of CVD after HBO had a 9% higher risk of CVD than those without. Both HA and HBO were linked to elevated risks of ischemic stroke and IHD, but not with hemorrhagic stroke. Women who had either HA or HBO increased risks of ischemic stroke and IHD, and these risks should be considered when assessing these interventions.
Source link: https://doi.org/10.1161/strokeaha.121.037305
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