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Oedema - Crossref

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Last Updated: 24 July 2022

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Goreisan alleviates cerebral oedema by inhibiting aquaporin 4 function: In vivo study using an established mouse model of cerebral oedema

Consequently, we investigated the mechanisms of action of GRS against headaches by focusing on brain fluid dynamics. To determine the effects of GRS on related symptoms and brain water content, we used a well-established mouse model of cerebral oedema. To determine water balance in the brain, the mouse model was also exposed to magnetic resonance imaging using H 217 O. In vitro, the effect of GRS on water permeability by aquaporin 4 was investigated. By reducing the increase in brain water content, GRS reduced the loss of righting reflex and survival in the mouse model. According to a MRI review of water dynamics, GRS reduced water flow into the brain. GRS inhibited AQP4 function in Xenopus laevis oocytes that expressed AQP4 in a study. These findings reveal more insight into the reducing effects of GRS on headaches caused by cerebral oedema.

Source link: https://doi.org/10.21203/rs.3.rs-1751338/v2


Goreisan alleviates cerebral oedema by inhibiting aquaporin 4 function: In vivo study using an established mouse model of cerebral oedema

Methods We evaluated the effects of GRS on related signs and brain water content using a well-established mouse model of cerebral oedema. In vitro, the effect of GRS on water permeability by aquaporin 4 was investigated to elucidate the mechanism of action. Results GRS reduced the loss of righting reflex and survival in the mouse model by reducing the increase in brain water content by reducing the increase in brain water content. GRS reduced the maximum signal intensity change in the cortex and the areas under the curve in the cortex and lateral ventricle, according to the same mouse model, and MRI analysis of water dynamics using H 217 O-derived signal changes. GRS decreased water permeability in Xenopus laevis oocytes expressing AQP4 by suppressing AQP4 function, according to an analysis of water permeability in Xenopus laevis oocytes expressing AQP4 mutation. GRS prevents cerebral oedema and related conditions in part by limiting AQP4 water permeability.

Source link: https://doi.org/10.21203/rs.3.rs-1751338/v1


Anti-Inflammatory Activity of Salvadora persica L. against Carrageenan Induced Paw Oedema in Rat Relevant to Inflammatory Cytokines

The anti-inflammatory activity of aqueous alcoholic crude extract and ethyl acetate extract of miswak sticks in carrageenan's induced rat oedema was investigated in terms of immunological characteristics. Adult male sapargue dawely rats were divided into four groups, group I was given the kit, group II received crude alcoholic extract orally at 100 mg/kg, and group III was notified as standard reference, and group IV received indomethyl acetate extract orally. The inhibition percentage of inflammation in a time-dependent manner was 7 percent for crude extract and 27 percent for ethyl acetate extract, with a significantly reduced oedema thickness in a time-dependent manner. The ethyl acetate extract from the last hour of follow-up shows potent behaviour to be nearly the same as indomethacin use on all measured parameters. The experimental findings revealed that Salvadora persica extracts had remarkable anti-inflammatory activity.

Source link: https://doi.org/10.15835/nsb346378


THE EFFECT OF ESTRIOL-16,17-DIHEMISUCCINATE ON VASCULAR PERMEABILITY AS EVALUATED IN THE RAT PAW OEDEMA TEST

When cobra venom was used as an inducer, it was a rapid and long-lived form. Furthermore, cyproheptadine reacted to the rapid onset of the cobra venom oedema caused by kaolin or the delayed phase of the cobra venom oedema. Phenylbutazone responded to the slow and long-lasting swelling induced by kaolin and the snake venom's postponed phase of swelling, but had no effect on any immediate and transient oedema or early stages of oedema caused by snake venom, as well as the early stage of oedema caused by snake venom.

Source link: https://doi.org/10.1530/acta.0.0490403


Precocious puberty secondary to massive ovarian oedema in a 6-month-old girl

Breast and pubic hair growth was credited to a 6-month-old baby. Both solid and cystic changes were found bilaterally enhanced ovaries in bilaterally enlarged ovaries, according to Ovarian ultrasound scans. There were no signs of neoplasia, only evidence of neoplasia, but there was stromal oedema associated with a diagnosis of widespread ovarian oedema. This entity is poorly understood in the paediatric literature as a source of sexual precocity, and has never been mentioned in such a young patient.

Source link: https://doi.org/10.1530/eje.0.1500119


Peripheral Oedema

On the other hand, lymph oedema refers to the swelling that normally occurs in either one or both arms or legs due to a blockage of the lymphatic system, leading to a feeling of heaviness and tightness, persistent infection, and skin fibrosis. Although lymphoedema also affects the back of the foot and toes, lipoedema spares foot and toes are also involved.

Source link: https://doi.org/10.1093/med/9780198850311.003.0022


Approach to the patient with oedema

One starts quickly after convulsive heart disease, the nephrotic syndrome, or primary sodium retention, using mostly loop diuretics. Patients with cirrhosis and ascites have fluid removal, but those without peripheral oedema must go further, often only 0. 5 kg/day or less. For other signs of generalized oedema, loop diuretics are usually used, and higher split doses may be required. Patients with receptive oedema from any cause may require high-dose loop diuretics as a result of a diuretic's action in the nephron, primarily a thiazide diuretic but also occasionally potassium sparing drugs.

Source link: https://doi.org/10.1093/med/9780199592548.003.0030_update_001


Pathophysiology of oedema in nephrotic syndrome

The mechanism by which serum proteins are leaking into the urine leads to an increase in extracellular fluid volume and oedema has become more apparent. Low colloid oedema as a result of serum oedema omission, leading to the influx of extracellular fluid from the intravascular compartment. Although low osmotic pressure may play a role in the clinical presentation of nephrotic syndrome, a number of studies indicate that underfilling is not a common symptom other than in the most severe nephrotic syndrome. In addition, the varying in colloid osmotic pressure between serum and interstitium appears to be stable in nephrotic syndrome. excess extracellular fluid in patients with nephrotic syndrome is noticeably different in patients with glomerular filtration reduction as the cause of sodium retention in patients with glomerular filtration rate reduced.

Source link: https://doi.org/10.1093/med/9780199592548.003.0053


Raised intracranial pressure, cerebral oedema, and hydrocephalus

CSF-rich cerebrospinal fluid, CSF, and the blood contained within the brain vessels are also embedded within the intracranial compartment. Because of brain oedema, changes in CSF flow, mass lesions, and cerebral engorgement of the brain, Intracranial pressure can be disrupted. The proper control of intracranial pressure is outlined in this chapter, as well as some common disease states in clinical neurology that are characterized by either primary or secondary difficulties in intracranial pressure dynamics are described.

Source link: https://doi.org/10.1093/med/9780198569381.003.0604

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions