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The use of selective serotonin reuptake inhibitors can raise the risk of gastrointestinal bleeding. The aim of this research was to see if the introduction of SSRIs in patients already taking NSAIDs raises their risk of elevated GI bleeding. Patients with elevated GI bleeding on NSAIDs with SSRIs were found in patients with upper GI bleeding on NSAIDs with SSRIs, according to Cohort and case-u2013control studies, where NSAIDs with SSRIs were only included in comparison to controls on NSAIDs only. For an odds ratio of upper GI bleeding in patients on NSAIDs with concomitant SSRI use, dichotomous data was pooled to establish an odds ratio. Compared to NSAIDs alone, the main endpoint of the report was the risk of upper GI bleeding with SSRIs and NSAIDs relative to NSAIDs alone. Patients on NSAIDs with concomitant SSRI use had an elevated risk of upper GI bleeding, which was an additional risk of upper GI bleeding. The concomitant use of SSRIs in patients on NSAID therapy can greatly raise the risk of upper-GI bleeding in patients already on NSAID therapy.
Source link: https://doi.org/10.1038/s41598-022-18654-2
Background The use of a prescription of diclofenac or indomethacin was shown to be a safe prevention tool for post-endoscopic retrograde cholangiopancreatography pancreatitis. Only randomized controlled trials reported rectal administration of 100 mg or higher doses of diclofenac or indomethacin, with PEP as the primary outcomes that were eligible for inclusion, with PEP being the primary outcomes. PEP overall was 7. 2%, 5. 0% for mild PEP, and 1. 5% for moderate and severe PEP. Patients receiving rectal indomethacin were more likely than those receiving rectal diclofenac drugs, according to a study by patients receiving rectal diclofenac. PEP rates in high-risk patients and average-risk patients were 8. 9% and 6. 4% respectively, respectively. PEP in patients receiving 100 mg rectal indomethacin were higher than patients receiving 100 mg diclofenac. A new investigation into the effects of 100 mg diclofenac versus indomethacin on PEP may be needed.
Source link: https://doi.org/10.1007/s11605-022-05399-6
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