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Nsaid - DOAJ

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Last Updated: 25 September 2022

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NSAID-Induced Enteropathy Affects Regulation of Hepatic Glucose Production by Decreasing GLP-1 Secretion

In animals that eat a high-fat diet, chronic administration of multiple NSAIDs to C57Blk/6J mice leads to ileal ulceration and weight loss in animals. Despite losing weight, NSAID-treated mice show no improvement in their glucose tolerance despite losing weight. Exendin-9u2014a GLP-1 receptor antagonistry reduces glucose tolerance in the control group but not in the NSAID-treated group. Endogenous glucose production, total glucose disposal, and their associated insulin levels remained unchanged among an ibuprofen-treated group and its control group, according to the hyper-insulinemic clamp report. insulin levels in the ibuprofen group have been reduced relative to their controls for the same glucose exchange rates in both directions. Conclusions: Chronic NSAID use can lead to small intestinal ulcerations, which can influence intestinal GLP-1 production, hepatic insulin sensitivity, and, ultimately, hepatic glucose production.

Source link: https://doi.org/10.3390/nu14010120


Potential for Detection of Safety Signals for Over-the-Counter Medicines Using National ADR Spontaneous Reporting Data: The Example of OTC NSAID-Associated Gastrointestinal Bleeding

The results of the National spontaneous adverse drug reaction survey findings are a valuable potential data source for the detection of safety signals related to OTC drugs, but no information is available regarding the possibility of detecting safety signals for OTC drugs within these datasets. As an example, OTC non-steroidal anti-inflammatory drugs and gastrointestinal bleeding were examples used to investigate safety signals for OTC medications in National ADR spontaneous reporting data. The ability of using spontaneous reporting data, determining the relationship between gastrointestinal bleeding and the use of OTC NSAIDs was tested using OTC NSAIDs from the Australian Adverse Drug Reactions System and the Canadian Vigilance Adverse Reaction Online Database. This research shows that spontaneous ADR reporting results can be used in pharmacovigilance to track OTC medication safety.

Source link: https://doi.org/10.3390/pharmacy8030174


Effect of Combined Bee Venom Acupuncture and NSAID Treatment for Non-Specific Chronic Neck Pain: A Randomized, Assessor-Blinded, Pilot Clinical Trial

This research was designed to determine the safety of a combination of bee venom acupuncture and non-steroidal anti-inflammatory drugs for the treatment of non-specific chronic neck pain. Patients with NCNP for u22653 months were randomly assigned to a BVA, NSAIDs, or mixed group, receiving six sessions of BVA, loxoprofen, or a mixture, respectively, for 3 weeks. Bothersomeness, pain, disability, and depressive symptoms all improved after therapy. For the treatment of NCNP, combined BVA and NSAID therapy is cost-effective, demonstrating high persistence, reliability, and safety.

Source link: https://doi.org/10.3390/toxins13070436


Fetal adverse effects following NSAID or metamizole exposure in the 2nd and 3rd trimester: an evaluation of the German Embryotox cohort

Methods This is a summary of the study The results of a survey conducted in the 2nd and/or 3rd trimester found that the pregnancies with NSAID and/or metamizole exposure in pregnancy was compared to pregnancies exposed to NSAID and/or metamizole in the 1st trimester only. To determine causality between study medication and study endpoints, the WHO-UMC protocol was used to determine causality. Results Ductus arteriosus constriction was diagnosed in 5/1092 in the study cohort compared to 0/1154 pregnancies in the comparison group, which was consistent. After long-term NSAID exposure, in one fetus, ductus arteriosus constriction, and oligohydramnios occurred in the late 2nd trimester. In the study cohort, 41/1092 cases were diagnosed in the study cohort relative to 29/1154 in the comparison cohort [RR, 1. 5 ]. During multiple weeks, At least four of the two first trimesters' exposed pregnancies. However, using oligohydramnios and ductus arteriosus constriction in longer stretches in the advanced 2nd trimester may result in oligohydramnios and ductus arteriosus constriction similar to those seen after 3rd trimester use.

Source link: https://doi.org/10.1186/s12884-022-04986-4

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions