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Last Updated: 25 August 2022

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An IBD-associated pathobiont synergises with NSAID to promote colitis which is blocked by NLRP3 inflammasome and Caspase-8 inhibitors

ABSTRACT BACKING CONCERNIAL bowel disease is a disorder that occurs when a combination of non-steroidal anti-inflammatory drugs intake is linked to chronic inflammatory bowel disease progression. We show inflammation of colitis in AIEC-colonized rabbits fed NSAID, using IL10-/- mice. Inhibition of NLRP3 or Caspase-8 infection exacerbated colitis, with decrease in NLRP3 production, cell death markers, and activated T-cells and macrophages, improved histology, and a greater number of Clostridium cluster XIVa species. Hence, targeting the NLRP3 inflammasome and Caspase-8 may be a potential therapeutic strategy in patients with NSAID-worsened inflammation.

Source link: https://doi.org/10.1101/2022.08.18.504384


OP0153 PRECONCEPTIONAL NSAID TREATMENT IS ASSOCIATED WITH LONGER TIME-TO-CONCEPTION IN WOMEN WITH SPONDYLOARTHRITIS: ANALYSIS OF THE PROSPECTIVE GR2 COHORT

Spondyloarthritis is one of the most common chronic inflammatory disorders that affects women of childbearing age 1. Objectives The aim of the study was to discover factors associated with time-to-conception in women with SpA. Methods We performed an investigation of SpA patients from 2015 to June 2021 in the national multicenter cohort GR2 from 2015 to 2021. Patients may have been included either as a result of a pregnancy wish or as a result of a clinical pregnancy: for this review, only patients who were preconceptionally were included. To account for heterogeneity of practices among participating centers, we conducted survival studies using a Cox model with a random effect for the center. Among the 207 patients with SpA enrolled in the GR2 study, 88 were selected for time-to-conception analysis. Subtility was present in 40 women, and the median time-to-conception was 16. 1 months. The mean preconceptional BASDAI score was 2. 9, which was the lowest. Conclusion This article contains original results on fertility in women with SpA. Age and the NSAIDs used during the preconception period were the two primary factors behind a longer time to conception, which argued for their cautious use in the case of pregnancy wish in patients needing continuous NSAID intake for the treatment of their disease. According to the use of NSAIDs in the preconception period, Cumulative incidence curves for pregnancies in women with SpA differed. Acknowledgements The GR2 Cohort is sponsored by the French Society of Rheumatology, the French Internal Medicine Society, and unrestricted grants from the University of Cambridge.

Source link: https://doi.org/10.1136/annrheumdis-2022-eular.2031


ICAM-1 and P-selectin expression in a model of NSAID-induced gastropathy

In a model of NSAID-induced gastropathy, the aim of this study was to determine whether endothelial cell adhesion molecules is improved. The intercellular adhesion molecule 1 or P-selectin was present in the Indo administration at 1 and 3 h after the use of a dual radiolabeled monoclonal antibody method. After Indo regime, P-selectin expression was dramatically increased at 1 h but not 3 h after Indo administration, but not 3 h after Indo administration, whereas ICAM-1 expression was substantially elevated at both 1 and 3 h after Indo treatment. However, Indo-induced gastropathy was not related to significant PMN penetration into the gastric mucosal interstitium, nor did Indo reduce gastric mucosal blood flow. The synthesis of P-selectin and ICAM-1 may be responsible for this NSAID-induced gastric mucosal injury, according to we; however, this mucosal injury does not appear to be dependent on inflammatory cells transplantation or mucosal ischemia.

Source link: https://doi.org/10.1152/ajpgi.1998.274.2.g246


Comprehensive Evaluation and Unique Morphologic Features of Nonsteroidal Anti-Inflammatory Drug (NSAID) Enteropathy in the Terminal Ileum

Differentiating NSAID enteropathy from Crohn disease can be difficult on terminal ileum biopsy. The comparisons were made between 30 patients with NSAID enteropathy and 30 patients with Crohn disease on terminal ileal biopsy. MRI results that were not present before biopsy were found by none of the patients in the NSAID cohort. Patients with Crohn disease had imaging findings ranging from minimal improvements to significant bowel wall and/or luminal changes, depending on disease severity. Patients with chronic Crohn disease were found to have erythema, ulcers, closeures, and/or visible inflammation throughout the distal ileum and colon. Compared to the NSAID cohort, the Crohn disease cohort had notably elevated degrees of lymphoplasmaemic inflammation in the lamina propria.

Source link: https://doi.org/10.1177/10668969221076549


Selecting an NSAID

Nonsteroidal anti-inflammatory drugs are a key component of multimodal analgesia. First, tell the world that the pain is expected to be related to NSAIDs. The most effective for nociceptive pain, and especially from an inflammatory source, is NSAIDs. To minimize the risk of gastrointestinal adverse effects, use COX-2 specific NSAIDs and proton pump inhibitors. Patients with a history of or high risk of cardiovascular disease should avoid COX-2 selective agents.

Source link: https://doi.org/10.1093/med/9780197542873.003.0009


Effects of anti-inflammatory (NSAID) treatment on human tendinopathic tissue

According to the Victorian Institute of Sports Assessment-Achilles' scores for tendon function, tendon thickness, and color Doppler were measured before and 1 h after therapy. The placebo treatment improved the Doppler's color when compared to the ibuprofen group, as well as the perception of pain at rest. There was no evidence that short-term ibuprofen treatment influences gene expression in human chronic tendinopathic tendonopathy or leads to any significant changes in tendon pain or function. In vivo, we find that 1 wk of ibuprofen therapy has no effect on gene expression of collagen and other growth factors in adult human tendinopathic tendinopathy, suggesting that tendinopathic cells are not sensitive to ibuprofen.

Source link: https://doi.org/10.1152/japplphysiol.00281.2017


Synthesis of Nonsteroidal Anti-Inflammatory Drug (NSAID) 2,4,5-Trimethoxybenzaldehyde from Indonesian Calamus oil and Its In Silico Pharmacokinetic Study

Those new Nonsteroidal Anti-inflammatory Drugs used as an inflammation adjunct therapy in the COVID-19 patients, including Parasol, Ibuprofen, and Celecoxib, are also in need of emergency delivery of a new potent NSAID. An article on the synthesis of 2,4,5-trimethoxybenzydehyde from Indonesia Sweet Flag and as well as its pharmacokinetic properties investigated by silico calculation was published. After doing reduced pressure distillation of the crude Indonesian Sweet flag oil, a typical Asian tetraploid calamus oil was yielded in 90 percent pure.

Source link: https://doi.org/10.1139/cjc-2022-0121

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions