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We report a case of a 63-year-old woman with normal-tension glaucoma who developed a shallow anterior chamber with moderately low intraocular pressure after combining ab-interno trabeculotomy and phacoemulsification. This is the first case to illustrate the clinical course of spontaneous CDC closure in a patient with NTG following ab-interno trabeculotomy. If CDC is established, it is advisable to warn the patient of a sudden closure after CDC is confirmed.
Source link: https://doi.org/10.7759/cureus.23276
Comparing to conventional controls in Korean, we aimed to obtain microRNA profiles of patients with pseudoexfoliation glaucoma or normal-tension glaucoma. In AH samples of PEX glaucoma and NTG patients, respectively, a total of 334 and 291 discrete miRNAs were discovered.
Source link: https://doi.org/10.1038/s41598-022-09572-4
Patients with NTG or POAG with more than one outpatient or discharge diagnosis from the ophthalmology department were included in the study. Patient data were obtained from Taiwan's Longitudinal Health Insurance Database 2000 for the 2008 to 2013 period, which was used to determine fine particulate matter exposure levels in patients with normal-tension glaucoma and primary open-angle glaucoma. The OR of the PM2. 5 Q3 level was 1. 009 compared to the PM2. 5 Q1 level of 1. 241, and the PM2. 5 Q4 level was 1. 246 compared to the PM2. 5 Q1 level of 1. 009. The risk of developing NTG is more closely linked to PM2. 5 exposure than with POAG, according to our studies, and PM2. 5 has a concentration-dose effect.
Source link: https://doi.org/10.3390/ijerph19074224
The mechanism of autonomic dysfunction and glaucoma progression is unclear. Autonomic dysfunction can be directly controlled by the autonomic nervous system, contributing to irregular or fluctuating blood pressure. Autonomic disorders, according to the hypotheses, can impair ocular blood flow and contribute to glaucoma formation. However, no scientific study has yet to investigate the correlation between ocular blood flow and autonomic nervous function. We recently had a 152 open angle glaucoma patient. vessel density was determined by using optical coherence tomography angiography, and autonomic nervous function was evaluated with heart-rate variability parameters. The deep parapapillary VD's diminished LF/HF ratio was attributed to a higher LF/HF ratio. In multivariate analysis, linear regression analysis revealed a strong negative correlation between parapapillary choroidal VD and LF/HF ratio. We demonstarted the connection between impaired ocular blood supply and autonomic dysfunction.
Source link: https://doi.org/10.1038/s41598-022-09162-4
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