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Normal intraocular pressure, progressive retinal cell death, and glaucomatous visual field loss are all typical in optic neuropathy, characterized by normal intraocular pressure, progressive retinal ganglion cell death, and glaucoma. NTG-related medications such as monitoring intraocular pressure, neuroprotection, and reduction of RGC degeneration may be more effective for NTG. Glutamate neurotoxicity is induced by overstimulation of N-methyl-D-aspartate membrane receptors by glutamate, a chemical that occurs in RGCs and promotes progressive glaucomatous optic neuropathy. Oxidative stress has also contributed to NTG-related glaucomatous optic neuropathy. As a result of NTG, Endothelin 1 causes endothelial dysfunction and ocular blood flow, promotes vaping and glaucomatous optic neuropathy. In conclusion, we discussed development on potential RGC coverts, including TANK binding kinase 1 inhibitors regulating autophagy, N-methyl-D-aspartate receptor antagonists restricting mitochondrial function, ASK1 inhibitors regulating mitochondrial function, and antioxidants inhibiting oxidative stress. RGC death in NTG is controlled by a network of mechanisms, but various potential targets shield RGCs, according to various potential targets.
Source link: https://europepmc.org/article/MED/35799514
Normal intraocular pressure is a normal intraocular pressure glaucoma, which is characterized by retinal ganglion cell death leading to cupping of the optic nerve head and visual field loss at normal intraocular pressure. We're posting a single nucleotide mutation in exon 2 of the methyltransferase like 23 gene of a three-generation Japanese NTG family. METTL23 is a histone arginine methyltransferase found in murine and macaque RGCs. However, Mettl23 expression in RGCs of Mettl23G/G mice decreased because of both clinical and genetic phenotypes, which recapitulated both clinical and genetic phenotypes. These results point to an etiologic role for METTL23 in NTG with tissue-specific pathology.
Source link: https://europepmc.org/article/MED/36099048
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