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To determine the potential diagnostic value of retrobulbar hemodynamic changes in NTG patients. With significant heterogeneity among NTG patients, there was a substantial decrease of PSV with moderate heterogeneity and a significant decrease of EDV in OA. RI in CRA and TPCA showed statistically significant increases in RI among significant heterogeneities, but RI in OA and NPCA showed no statistical changes with significant heterogeneities.
Source link: https://doi.org/10.1155/2015/919610
Purpose In glaucoma subjects, the aim was to investigate the correlations between optic nerve head strains under intraocular pressure elevation with retinal sensitivity. Methods For one eye of each patient, we imaged the ONH using spectral-domain optical coherence tomography under the following conditions: acute IOP elevation caused by ophthalmodynamometry and primary gaze. In each ONH, a three-dimensional strain-mapping system was used to determine IOP-induced ONH tissue strain. Results For HTG participants, we found significant negative linear correlations between ONH strains and retinal sensitivity, high strain regions co-localized with anatomically-mapped areas of high visual field loss, and the most prominent negative associations were recorded in the superior region and PLT. Conclusion In a relatively large glaucoma population, there were clear negative associations between IOP-induced ONH strains and retinal sensitivity. Specifically, HTG patients with elevated ONH strains were more likely to have lower retinal sensitivities.
Source link: https://doi.org/10.1101/2021.12.15.472712
Purpose: Objective: To investigate optic nerve head deformations and strains during adduction, abduction, and intraocular pressure elevation in subjects with high-tension glaucoma and normal-tension glaucoma. For all scenarios, we also digitally linked the OCT volumes obtained from - to the primary gaze volume before performing digital volume correlation analysis to determine IOP- and gaze-induced ONH tissues three-dimensional displacements and effective strain. Interestingly, the LC of HTG subjects demonstrated significantly higher strain resistance than those of NTG subjects under IOP elevation. Interestingly, the LC tissue of NTG patients under adduction displayed notably higher strain than that of HTG subjects. NTG subjects were also affected by increased strains due to adduction than HTG controls, while HTG subjects suffered greater strain due to IOP elevation than NTG controls, according to the LC tissue, and that these differences were most evident in the LC tissue.
Source link: https://doi.org/10.1101/2021.08.25.457300
Background: Mydriasis' effect on intraocular pressure in normal tension glaucoma eyes has not been investigated. In addition, although filtration surgery is a method that can lower IOP under normal conditions and reduce IOP fluctuation, the effect on IOP after mydriasis is unknown. Against this backdrop, we investigated the effect of mydriasis on IOP and trabeculectomy on mydriasis-induced IOP and trabeculectomy in the same patients with NTG. Methods: We discovered results for NTG patients who were regularly monitored for more than five years before and after surgical periods. The IOP difference between the mydriatic and non-mydriatic states was determined as the IOP difference between the mydriatic and non-mydriatic states. Conclusions: For the first time, we found that pharmacological mydriasis significantly raised IOP, but trabeculectomy may have reduced not only IOP but also mydriasis-induced IOP changes in patients with NTG.
Source link: https://doi.org/10.21203/rs.3.rs-1423076/v1
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