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Object Although neuron transplantation to restore the nervous system has shown promise in animal models, there are no reliable neuron source for clinical use and ineffective strategies to overcome significant nerve damage in patients. Due to their cultural robustness, the authors chose to investigate human dorsal root ganglion neurons. In addition, dissociated human DRG neurons were placed in a specially created axon expansion chamber that causes constant mechanical tension on axon fascicles spanning two populations of neurons plated 100 m apart. Stretch-growth of axon fascicles in the expansion chamber increased at a rate of 1 mm/day to a length of 1 cm, creating the first engineered living human nervous tissue constructs. These results, as well as organ donors, serve as an allograft source of neurons.
Source link: https://doi.org/10.3171/jns/2008/108/2/0343
In rat interscapular brown adipose tissue, the effect of cold exposure or prolonged norepinephrine infusion was investigated. In denervated pads from rats kept at 25°C and suppressed in these pads, the cold-induced rises in both GyK activity and mRNA levels resulted in reductions of 50% and 30 percent in GyK activity and mRNA levels, respectively. After 6 h of continuous subcutaneous infusion of norepinephrine with phenoxybenzamine, the increase in GyK activity triggered by cold exposure was not affected by phenoxybenzamine, but it was severely limited by previous use of propranolololol or actinomycin D. BAT GyK activity did not change dramatically after 6 h of infusion, but it did not rise much after 72 hours of infusion. In BAT from rats exposed to cold, the incorporation of glycerol into glyceride-glycerol was up in vitro.
Source link: https://doi.org/10.1152/ajpregu.00764.2002
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