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Necrotizing fasciitis is a rare and serious infectious disease that is often fatal, and it is characterized by extensive necrosis of subcutaneous tissue and fascial planes. Both 12 and 26 patients with necrotizing fasciitis and cellulitis, respectively, were recruited retrospectively by 38 patients, including 12 and 26 patients with necrotizing fasciitis and cellulitis. The results of routine blood tests were obtained at disease onset and at baseline, which was defined as the time point in disease diagnosis. No significant differences were found between the necrotizing fasciitis and cellulitis groups in age or sex. However, significant differences were noted in hemoglobin, lymphocyte count, platelet count, neutrophil-to-lymphocyte ratio, neutrophilto-lymphocyte ratio, sodium, creatinine, albumin, Ddimer, and Laboratory Risk Indicator for Necrotizing Fasciitis score at disease onset, as shown by the following figures: At disease onset. In conclusion, the present findings revealed pre-critical abnormalities in routine blood tests in patients with necrotizing fasciitis. Therefore, people susceptible to necrotizing soft tissue disease may be identified well before disease development.
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