Necrotizing Fasciitis - Europe PMC

Focus on Ophthalmopathology - Orbital Infections from Hordeolum to Necrotizing Fasciitis.

However, these disease entities are rarely recognized by an ophthalmic pathologist because orbital infections are usually diagnosed clinically, with the support of imaging and microbiological techniques when indicated. The role of ophthalmopathology in the diagnosis of orbital infections is illustrated in this review essay on the basis of several exemple diagnoses. An infectious hordeolum must be distinguished from a noninfectious chalazion. Canaliculitis diagnosis and treatment are often postponed. An elevated incidence of mucormycosis infections was recorded during the Sars-CoV2 pandemic, particularly in India.

Source link: https://europepmc.org/article/MED/35858598

Postoperative empyema complicated with descending necrotizing fasciitis: a case report.

Empyema is a significant complication of lung surgery and is a significant complication of lung surgery. Case presentation We present a case of Streptococcus anginosus empyema complicating the process of descending necrotizing fasciitis after surgery. On the ipsilateral iliac crest, a palpable pink erythematous skin change was noticed one week after the emergency surgery. Conclusions When Streptococcus anginosus is detected, it should be considered that the possibility of descending abscess and necrotizing fasciitis should be investigated.

Source link: https://europepmc.org/article/MED/35836035

HLA-II-dependent neuroimmune changes in Group A Streptococcal Necrotizing Fasciitis

Streptococcus pyogenes bacteria cause a variety of human ailments, from self-limiting pharyngitis and mild uncomplicated skin infections to severely impaired and fast-invasive life-threatening infections such as streptococcus fibrinopathy and necrotizing fasciitis. In an HLA-II transgenic mouse model of GAS skin disease in a HLA-II transgenic mouse model of GAS NF with and without treatment with an antibiotic, clindamycin, we investigated the effects of peripheral GAS skin inflammation on the brain. Methods Mice expressing the human HLA-III DR3 or the HLA-III DR4 alleles were divided into three groups: ii uninfected controls, ii subcutaneously infected with a clinical GAS strain isolated from a patient with GAS disease, and iii autoimmune disease patients with CLN therapy 10 mg/kg/5 days intraperitoneal. However, CLN treatment has dramatically reduced GFAP immunoreactivity in DR3 mice but not in DR4 mice.

Source link: https://europepmc.org/article/PPR/PPR514247

Necrotizing Fasciitis In A Patient with Metastatic Clear Cell Ovarian Carcinoma Treated with Bevacizumab.

BACKGROUND Necrotizing fasciitis is a life-threatening disease of the deep soft tissues that causes progressive skin loss of the fascia and subcutaneous fat. Muscle tissue is generally spared due to its increased blood supply. Trauma, hunger, excess, uncontrolled diabetes mellitus, uncontrolled diabetes mellitus, alcoholism, cirrhosis, neutropenia, and recent surgery are all typical risk factors for necrotizing fasciitis. CASE REPORT We present a case of a middle-aged female with necrotizing fasciitis of the right gluteal region. She underwent surgery and debridement of right gluteal absces with drain of 200 ml of foul-smelling pus and was introduced on intravenous antibiotics. Her blood cultures were negative, but Escherichia coli cultures obtained from the right gluteal abscess demonstrated modest growth. With an outpatient follow-up, the antibiotics were de-escalated and the patient was discharged. BEvacizumab, a humanized monoclonal IgG antibody, is a novel therapy for metastatic ovarian cancer.

Source link: https://europepmc.org/article/MED/35751369

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