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Naloxone - Springer Nature

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Last Updated: 13 September 2022

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Buprenorphine/naloxone versus methadone opioid rotation in patients with prescription opioid use disorder and chronic pain: study protocol for a randomized controlled trial

While opioid prescription opioid use disorder is prevalent in pain-management, long-term opioid users can suffer with prescription opioid use disorder. A short-acting opioid is giving way to a long-acting opioid in Patients with OUD. Both BuNa and methadone have been shown to be safe in patients with OUD decreasing opioid use, but data on head-to-head comparisons in patients with persistent non-malignant pain and prescription OUD are scarce, as well as OUD reducing prescription OUD. Methods This two-armed open-label, randomized controlled trial aims to determine the effectiveness of BuNa and methadone in patients with chronic non-malignant with prescription OUD. To determine change in outcome parameters as a result of time between the treatment arms, a Linear mixed model approach will be used to evaluate change in outcome parameters. Discussion This is one of the first studies to compare buprenorphine/naloxone/methadone and methadone for treating prescription OUD in a large patient population with chronic non-malignant pain. Patients with persistent pain and prescription OUD can potentially be influenced by future therapy for patients with persistent pain and prescription OUD.

Source link: https://doi.org/10.1186/s13722-022-00326-1


Patient perspectives on naloxone receipt in the emergency department: a qualitative exploration

Background The naloxone supply to patients at high risk of opioid overdose is essential, but no information is available about patient perceptions or best practices for patient education and communication. Interviews debating the importance of naloxone, as well as attitudes and experiences of receiving naloxone in the ED. Although most respondents expressed positive reactions about getting naloxone from the ED, the quality of discussions with ED providers was uneven, with some participants not even aware they were getting a naloxone prescription before discharge. These findings highlight the vital role that EDs play in mitigating patient risks for patients who are not affiliated with other health or community health services, as well as future research into the efficient implementation of harm reduction strategies in ED settings.

Source link: https://doi.org/10.1186/s12954-022-00677-7

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions