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NANCE-HORAN Syndrome - Crossref

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Last Updated: 02 April 2022

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Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration

During mesenchymal cell migration, several coinciding signals trigger Arp2/3 mediated lamellipodia formation, which can be initiated by several coinciding signals. In addition, active Rac links to NHSL1 in two regions that mediate leading edge targeting of NHSL1. NHSL1 seems to have limited cell migration by its contact with the Scar/WAVE complex, surprisingly. NHSL1 may reduce cell migration by impeding Arp2/3 activity, as shown in cells using a new Arp2/3 FRET-FLIM biosensor, which leads to reduced F-actin density of lamellipodia and consequently in impaired lamellipodia protrusion stability, as measured in cells.

Source link: https://doi.org/10.1101/2020.05.11.083030

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions