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Mutagen - Crossref

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Last Updated: 13 July 2022

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Abstract 3469: Effect of age and mutagen on the enriched murine mammary epithelial stem and progenitor cell population

Nevertheless, there is still no research into the causes that influence breast cancer initiation and promotion in older women. Functional mammary outgrowths indicating stem cell function are unaffected by the donor's age have been reported earlier by serial transplantation of murine mammary tissues. In this research, we first obtained lineage negative mammary gland cells from young and old mice's thoracic/inguinal mammary glands by serial enzymatic dissociation followed by a magnetic nanoparticle separation device. Although the frequency of mammosphere formation remained stable, the number of larger mammospheres from old mice was significantly lower than those from young mice, indicating reduced stem cell production in the older population. We treated two young and two old mice with methyl nitrosourea every week for three weeks in order to study mutagen's in vivo. Both total and larger mammospheres from the treated older mice's isolated Linu2212MEC were found in much greater numbers than those treated younger mice. These Linu2212MEC cells were also tested and compared for DNA damage caused by alkaline comet assay, and a larger percentage of cells with irreversible DNA damage in the older population were observed, in comparison to the younger population, indicating probable lower DNA repair capacity of the former cells. Thus, our preliminary results found that enriched stem/progenitor cells in the old mice with reduced in vitro stem cell production may be vulnerable to DNA damage caused by mutagens and subsequent tumorigenesis.

Source link: https://doi.org/10.1158/1538-7445.am10-3469


Abstract 4118: Hypoxia affects the metabolic activation and detoxification of the environmental mutagen benzo(a)pyrene

Since proper carcinogen metabolism is dependent on oxygen, we investigated how changing oxygen levels affected BaP metabolism by determining its activation and deactivation. During 18 hours, BaP was administered in different oxygen concentrations for 18 hours, and BaP-metabolism shifts were determined. First, we investigated BaP-induced expression of key metabolic enzymes; expression of CYP1A1 and CYP1B1 were elevated under hypoxia, while detoxifying enzymes UGT1A6 and UGT2B7 were significantly reduced by hypoxia; hypoxia caused the expression of key metabolic enzymes. Several BaP metabolites in supernatants were determined by HPLC-fluorescence analysis, indicating Then and several BaP metabolites in supernatants. In general, low oxygen levels lead to BaP breakdown, which occurs at a slower rate, leaving more of the parent substance intact. Eventually, under hypoxia DNA adducts built up over a period of 168 hours, whereas DNA adducts were quickly extracted under 20% oxygen, resulting in 1. 6 times higher adduct levels under hypoxic conditions.

Source link: https://doi.org/10.1158/1538-7445.am2012-4118


Abstract 3718: Well-done meat intake and meat-derived mutagen exposures in relation to breast cancer risk: The Nashville Breast Health Study

Abstract: Previous studies investigating the correlation between meat intake and meat-derived mutagen exposures with breast cancer risk have revealed inconsistent findings. In a population-based case-control analysis of incident breast cancer screening in Nashville, Tennessee, United States, which includes 2,386 breast cancer cases and 1,703 healthy women controls, we reviewed this association. Telephone interviews were conducted to collect data related to meat intake, including quantity, baking methods, and doneness levels, as well as other commonly reported or hypothesized risk factors for breast cancer. Breast cancer risk has been significantly elevated since a high intake of red meat. Postmenopausal women were more likely to experience breast cancer risk than premenopausal women. The findings from this analysis show that elevated red meat intake and meat-derived mutagen exposure may be associated with an increase in breast cancer risk.

Source link: https://doi.org/10.1158/1538-7445.am2011-3718


Abstract P3-08-01: Gamma-ray induced mutagen sensitivity and overall survival in young women with breast cancer

Abstract Background: Hypersensitivity to radiation has been shown to be a risk factor in breast cancer formation. In patients with breast cancer, we want to know if the same hypersensitivity predicts adverse clinical results. Methods: This report included 465 young, female, non-Hispanic white patients with carcinoma of the breast at our hospital from 1/1997 to 12/2005. The number of simple chromatid breaks per sample was determined from 50 well-spread metaphases. Each simple chromatic break was counted as a single break, and each isochromatic break, change figure, or interstitial deletion was counted as two breaks. The mean value of chromatid breaks per cell was then calculated and reported. To determine the hazard ratio and 95% confidence interval for the relationship between b/c and overall survival, the Cox multivariable proportional hazards model was used to estimate the hazard ratio and 95% confidence interval. Both 341 patients had invasive cancer and 253 patients had ER+ disease. stage 0, stage 1, stage 2, stage 3, and stage 4 were among AJCC's stage distributions, which included stage 0, stage 2, stage 2, stage 3, and stage 4. Patients with b/c higher than the median value of 0. 5 were seen with a statistically significant decline in 5- and 10-year overall survival in patients with b/c greater than the median value of 0. 5. Conclusions: A higher b/c score was predicted for reduced overall survival in this cohort of young, female, non-Hispanic white breast cancer patients. In young women with breast cancer survivors with breast cancer, Gamma-ray enhanced mutagen sensitivity and overall survival in young women with breast cancer. [abstract] In:: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium, Dec 9-13; San Antonio, Texas.

Source link: https://doi.org/10.1158/1538-7445.sabcs14-p3-08-01


Abstract 3099: Hydrocarbon carcinogenicity reexamined: An extremly potent direct-acting mutagen is common to smoke, soot and ash from a variety of combustion sources, including cigarette tobacco

Abstract Persuading Pott, an English surgeon, is widely credited with being the first to claim that cancer can be caused by environmental carcinogens u2013 in his case, scrotum cancer in London chimney sweeps occupationally exposed to soot. Those studies pointed toward a particular class of compounds as being primarily responsible for cancer induction by such products, a family of environmentally ubiquitous chemicals called polycyclic aromatic hydrocarbons (PAHs). Although BaP and its congeners are the primary carcinogens in incomplete combustion products such as coal tar, their concentrations in other hydrocarbon mixtures are too low to adequately account for their overall carcinogenic potency. It is possible that other factors such as tumor growth contribute to the increased potency, but it could also be expected that nitro-PAH derivatives, particularly the isomers of dinitropyrene, are among the key components of carbon black, diesel exhaust, and other combustion products, are responsible. Iwagawa et al. t al. showed one such isomer, 1,6-dinitropyrene, on display. Extracts of smoke soot, ash, and food products exposed to combustion product carcinogenesis were fractionated by HPLC, and the fractions determined in the Ames Test without metabolic activation were determined in order to indirectly measure nitroaromaticity in the combustion product carcinogenicity. Hydrogen's reexamined: An extremely strong direct-acting mutagen is used to inhale, soot, and ash from a number of combustion sources, including cigarette tobacco [abstract]. In:: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018-04-18; Chicago, Illinois.

Source link: https://doi.org/10.1158/1538-7445.am2018-3099


Abstract P2-03-08: Influence of mutagen exposure on molecular profile in breast cancer

Abstract Background: The study of several cancers has been revolutionized by the molecular profiling of tumor DNA. However, there is a paucity of evidence comparing the effects of mutagen exposure on molecular profil in other cancers. This is a pilot study to see if smoking history or prior adjuvant radiation has an effect on women with breast cancer's molecular profiles. Moffitt's Clinical Genomic Action Committee database was used to evaluate 62 patients with breast cancer treated at Moffitt with targeted deep sequencing of 315 genes as part of clinical care between 4/1/2013 and 12/31/2015. Moffitt's Clinical Genomic Action Committee database was used to analyze 62 patients with breast cancer treatment at Moffitt, including targeted deep sequencing of 315 genes as part of clinical care from 4/1/2013 to 12/31/2015. The history of adjuvant radiation therapy was determined by self-report and history of adjuvant radiation therapy, which was divorced from the medical record. The two groups were similar in terms of the percentage of triple negative patients between active/prior smokers and never smokers respectively, but the percentages were similar between active/prior smokers and never smokers. There was no difference in the genetic burden between 17 smokers and 42 never smokers; p=0. 35, with a trend towards more mutations in never smokers. Prior radiation and the 34 with prior radiation had no difference in the mutational burden between 26 patients without prior radiation and those with prior radiation, with no difference, and both groups had a mean of 11. 1 alterations. Conclusions: There was no difference in the mutational burden between smokers and never smokers in breast cancer or between breast cancer patients who underwent radiation therapy or those who did not. [abstract]: Influence of mutagen exposure on breast cancer's molecular profile [abstract]. In:: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, Texas; In:: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; 2016 San Antonio, Texas.

Source link: https://doi.org/10.1158/1538-7445.sabcs16-p2-03-08


Abstract 964: The association of meat intake, meat cooking methods, and meat-derived mutagen exposure with the risk of sessile serrated polyps

Abstract Colorectal polyps are the precursors of colorectal cancer, the second leading cause of cancer death in the United States, behind colorectal polyps. The mechanism for the association between red and processed meat intakes and adenoma risk remains unclear. This latest research expands on previous research by examining the links between meat intake, meat cooking techniques, and meat mutagens, which may pose SSP risks, as well as comparing the risks to conventional adenomas and hyperplastic polyps. In comparison to the lowest intake levels, the highest quartile total meat intake, red meat intake, processed meat intake, well-done red meat, well-done processed meat, and the HCA MeIQx were all found to have statistically significant risks of SSP in comparison to the lowest intake levels. SSP was more susceptible to SSP than for other forms of polyps in this group. In particular, MeIQx intake was not linked to risk of traditional adenomas, meaning that the mechanisms by which red meat intake influences polyp risk may be different between the traditional adenoma and serrated pathways may be different between the two common adenoma pathways. Future research is required to establish the connection between meat and meat mutagen intakes with SSP risk, as well as other ways in which intake of these factors influence SSP risk. The association of meat intake, meat preparation techniques, and meat-derived mutagen exposure can increase the possibility of sessile serrated polyps [abstract]. 2019: Abstract nr 964; Proceedings of the American Association for Cancer Research Annual Meeting, 2019 Mar 29-Apr 3; Atlanta, GA.

Source link: https://doi.org/10.1158/1538-7445.am2019-964


Unraveling the DNA Methylation in the rDNA Foci in Mutagen-Induced Brachypodium distachyon Micronuclei

We report DNA methylation in individual Brachypodium distachyon micronuclei that are caused by mutationagenic treatment with maleic acid hydrazide for the first time in this research. DNA methylation studies in specific DNA sequence locations are known in plants; however, no in situ analyses of DNA methylation in nuclei and micronuclei have been reported. Plant mutagenesis is greatly affected by gene expression, as these studies into the presence or absence of DNA methylation within specific DNA sequences are extremely important in plant mutagenesis.

Source link: https://doi.org/10.3390/ijms23126797


Mutagen Sensitivity: A Genetic Predisposition Factor for Cancer

Numerous epidemiologic studies have shown that mutagen sensitivity is a risk factor for a variety of epithelial cancers. A new classic twin study looked at the influence of genetic and environmental influences on the mutagen sensitivity phenotype, finding convincing evidence that mutagen sensitivity is highly heritable. Mutagen sensitivity is a risk factor for cancer risk factors, according to the evidence, which is getting more clear.

Source link: https://doi.org/10.1158/0008-5472.can-06-4137

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions