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Multiple Sclerosis - ClinicalTrials.gov

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Last Updated: 13 September 2022

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Cognitive-motor Telerehabilitation in Multiple Sclerosis

Compared to single cognitive and motor rehabilitation, the main purpose of this project is to show that a home-based combined cognitive-motor training curriculum improves cognition among people with multiple sclerosis. The main backbone of this program will be a randomized controlled two-centre clinical trial, in which an at-home computerised cognitive-motor rehabilitation service aimed at improving working memory in people with MS will be evaluated. In addition, factors that could predict treatment responses to the rehabilitation program will be identified.

Source link: https://clinicaltrials.gov/ct2/show/NCT05355389


Thematic Studies of Multiple Sclerosis and Related Diseases

Protocol includes only methods that have minimal risk or more-than-minimal risk that are safe and common in this study population. If additional participants are required, a memo will be sent to the Protocol Review Committee and the institution's statistical examiner to request the study of a hypothesis-testing subpoena for potential additional enrollment. The IRB will also receive the memo. These studies are intended to increase understanding of a disease process or assist in the diagnosis of an individual patient. These studies will be used to educate new investigators in techniques that are not relevant to the research under this protocol. Study Results According to the Survey Data The study participants will be divided into three groups of study participants: MS patients. MS is a disease that shares features with MS. Planning is divided into small substudies as new research that is relevant to the topic of MS pathophysiology. If a hypothesis testing sub-study yields results of interest, but if a larger population is required to reach statistical significance, a separate protocol will be submitted with a priori hypotheses, specific research design, and power analysis developed from the pilot or exploratory sub-studies performed in the present protocol. Outcome Measures These will include MRI, medical, and biological outcome measures that align with the study's objectives and investigators' goals. Imaging studies will focus on aspects of the central nervous system, particularly focal lesions. Standard and established MS disability scales as well as quantitative measures related to function will be included in clinical studies.

Source link: https://clinicaltrials.gov/ct2/show/NCT02504840


Exploratory Study of Entire-body PET Scans for Multiple Sclerosis

The pilot study will be conducted on 20 participants as a clinical research trial of F18-florbetapir radiotracer activity in MS patients relative to healthy controls, as well as the secondary aim of monitoring psychological health of those participants who wish to be informed of imaging findings and who complete a questionnaire of psychometric scales before and after imaging results publication.

Source link: https://clinicaltrials.gov/ct2/show/NCT04390009


Natalizumab in Preventing Post-partum Relapses in Multiple Sclerosis

Patients with multiple sclerosis with a diagnosis of multiple sclerosis will be able to enroll in this research that will determine the effectiveness of IV natalizumab to reduce postpartum relapses. Patients who experience natalizumab treatment postpartum will be eligible to enroll in the study in the control group. As determined by qualitative MRI results, the secondary objectives of the trial were to determine the efficacy of natalizumab in reducing the risk of disability progression during the postpartum period and to avoid the occurrence of new and/or enlarging brain MRI lesions.

Source link: https://clinicaltrials.gov/ct2/show/NCT03046251


Evaluation of Progression in Multiple Sclerosis by Magnetic Resonance Imaging (MRI)

Multiple MRI procedures of tissue damage, including the detection of new on-study lesions, quantification of contrast-enhancing lesions, the total number and/or number of MRI-visible lesions, mouse volume, and brain volume change, will be evaluated, as well as more sophisticated MRI techniques of tissue damage, such as quantitative magnetic relaxation mapping, diffusion-weighted imaging, and MR spectroscopy will be used to determine tissue damage. Two control cohorts one consisting of patients will be used to obtain comparative data for proper interpretation of the results in MS, the other of healthy volunteers will be tested in order to obtain comparable data for correct interpretation of the findings in MS. Patients with other CNS disorders that may have a common pathophysiologic pattern with MS patients will be included in the patient monitoring project. Enrollment of these control patient populations will help determine whether the MRI findings and/or pathophysiological pathways are MS-specific or generalizable.

Source link: https://clinicaltrials.gov/ct2/show/NCT00001248


The Reliability and Validity of the Figure of 8 Walk Test in Multiple Sclerosis

The prevalence of balance in MS patients with MS is high, as well as its clinical relevance, has pushed balance into a central focus in MS clinical practice and research. In the case of an 8-Walk Test, two cones are placed 1. 5 meters apart, establishing a universal clinical test used to measure forward walking endurance in daily life. The 8 Walk Test is a common clinical tool used to assess forward walking endurance in daily life. The aim of the study is to determine the validity and reliability of the 8-shape walking test in MS patients.

Source link: https://clinicaltrials.gov/ct2/show/NCT05433714


Promotion of Exercise Behavior Among Rural-Residing African-Americans With Multiple Sclerosis

Because only 1. 7% of participants in physical fitness and exercise research involving individuals with multiple sclerosis identifie as African-American, there is a lack of evidence from high-quality randomized controlled trials of exercise for African-Americans with multiple sclerosis. The African-American rural residing group has a unique challenge to MS research that addresses the unique challenges of MS in the African-American rural residing population. People with MS also have a very rich and refined exercise training program that can be carried out in one's home and/or local community, and does not include facility access that is extremely limited in the target, rural residing population of people with MS. There is no other research initiative that has delved so far in study refinement and design for immediate integration with a high-quality RCT for improving the lives of African-Americans with MS who live in rural communities of the Southeast United States' rural areas.

Source link: https://clinicaltrials.gov/ct2/show/NCT05516537

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions