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Healthy Caucasians and 10-15% in patients with myelodysplastic syndrome and acute myeloid leukaemia predisposing GFI-36N carriers to these diseases have a 5-7% incidence. Since GFI1 is involved in B cell maturation and plasma cell formation, we investigated its incidence in patients with multiple myeloma, a haematological disorder characteristic of increased clonal PCs, we investigated its prevalence in patients with multiple myeloma. MM patients had a higher incidence than those in MDS and AML than controls, according to a study. Patients gaining 1q21 showed poor progress free survival.
Source link: https://zenodo.org/record/6414782
Multiple myeloma is a hematological malignancy triggered by plasma cell proliferation's clonal expansion. The incidence of MM globally is on the rise, with more than 140,000 people being diagnosed with MM per year. While 5-year survivors following a diagnosis of MM has increased from 28 percent in 1975 to 56% in 2012, the condition is still incurable. Ongoing research into the origins and early detection of MM, as well as the development of novel therapies such as immunotherapies, may have the ability to influence MM practice in the future.
Source link: https://zenodo.org/record/6413925
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