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Multiple Myeloma - MedlinePlus Genetics

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Last Updated: 13 May 2022

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Multiple myeloma

Multiple myeloma is a cancer that occurs in the bone marrow, the spongy tissue found in the middle of most bones. The bone marrow produces red blood cells that transport oxygen throughout the body; white blood cells, which make the body's defenses; and platelets, which are required for blood clotting. Multiple myeloma is characterized by abnormalities in plasma cells, a form of white blood cell. These abnormal cells grow out of place, from one percent of bone marrow cells to the majority of bone marrow cells, extending from one percent to the majority of bone marrow cells. The abnormal plasma cells in several myeloma's multiple myeloma have proteins that hinder normal blood cell formation. Multiple myeloma patients have the disorder about age 65 in people with multiple myeloma.

Source link: https://medlineplus.gov/genetics/condition/multiple-myeloma


Congenital dyserythropoietic anemia

Congenital dyserythropoietic anemia is an inherited blood disorder that plays a role in red blood cell formation. This disorder, which is characterized by a red blood cell deficit, is one of several forms of anemia. Researchers have identified three key types of CDA: type I, type II, and type III. Moderate to severe anemia is associated with CDA type I. Many affected individuals have yellowing of the skin and eyes, as well as an enlarged liver and spleen. In particular, iron overload can lead to an abnormal heart rhythm, congestive heart failure, diabetes, and chronic liver disease. People of CDA type I are born with skeletal abnormalities, most commonly involving the fingers and/or toes. The anemia associated with CDA type II can range from mild to moderate, and the majority of individuals have jaundice, hepatosplenomegaly, and the forming of hard deposits in gallbladder called gallstones can vary from mild to severe. CDA type III's signs and symptoms are generally smaller than those of other categories. Most affected individuals have not had hepatosplenomegaly, and iron does not build up in tissues and organs. Vision loss can occur in adulthood as a result of abnormalities of a specific tissue at the back of the eye. Some people with CDA type III also have a condition known as monoclonal gammopathy, which can lead to a white blood cell cancer. Once researchers find the genetic causes of these variants, some of them can be grouped with the three main types of CDA.

Source link: https://medlineplus.gov/genetics/condition/congenital-dyserythropoietic-anemia

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions