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Multicenter Clinical Trial - Springer Nature

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Last Updated: 25 July 2022

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A randomized, parallel control and multicenter clinical trial of evidence-based traditional Chinese medicine massage treatment VS External Diclofenac Diethylamine Emulgel for the treatment of knee osteoarthritis

Background Both massage and topically administered NSAIDs are safe and effective for knee osteoarthritis treatment, but different massage sects in China contributed to evaluation challenges for treating KOA. knee osteoarthritis treatment in China We arranged multi-disciplinary experts in China in order to standardize the massage techniques and protocols in order to standardize the massage techniques and protocols. Compared to External Diclofenac Diethylamine Emulgel, the aim of this research is to provide clinicians with a complementary and alternative therapy for patients, as well as assessing the effectiveness and safety of evidence-based traditional Chinese medicine massage therapy for KOA. 100 participants will receive External Diclofenac Diethylamine Emulgel as the control group, while the experimental group's two hundred participants will receive evidence-based traditional Chinese medicine massage two sessions per week for ten weeks, and 100 participants will receive External Diclofenac Diethylamine Emulgel 30004 times per day for ten weeks as the control group.

Source link: https://doi.org/10.1186/s13063-022-06388-5


The effect of Bushen Culuan Decoction on anovulatory infertile women among 6 different diseases: a study protocol for a randomized, double-blinded, positively controlled, adaptive multicenter clinical trial

Background Anovulation is one of the leading causes of female infertility. A day and a day of every menstrual cycle will begin with Bushen Culuan Decoction 13 g three times a day and a five-day treatment with clomiphene citrate placebo tablets 50 mg begins on day 5 of every menstrual period. Once a day from day 5 in every menstrual cycle, the control group will undergo a 14-day surgical program with Bushen Culuan Decoction placebo 13 g three times a day, and a five-day treatment with clomiphene citrate tablets 50 mg. The Medical Ethics Committee of the Xiyuan Hospital China Academy of Medical Sciences has approved this research. This research is intended to determine whether Bushen Culuan Decoction results in a higher pregnancy rate than clomiphene citrate in women with anovulatory infertility and to determine the anovulatory diseases for which Bushen Culuan Decoction has improved success.

Source link: https://doi.org/10.1186/s13063-022-06289-7


Dual block HER2 assessment increased HER2 immunohistochemistry positive rate in resected specimens of gastric cancer: a prospective multicenter clinical trial from China

Background Information Former single center studies reported that HER2 examination with two primary tumor blocks could be a quick and cost-effective way to combat heterogeneity's negative effect on gastric cancer and achieve a HER2 positive rate in gastric cancer. Methods Anonymous GCs from 8 hospitals in China have been trained, with a total of 3806 patients with primary GCs. Following histological examination, two primary tumor blocks were identified and registered as block 1 and block 2 and block 2, respectively. Findings In total patients, the HER2 IHC positive rate with dual block testing was higher than that with single block assessment. In comparison, dual block assessment revealed a lower HER2 negative rate than single block analysis. In resected specimens of GC, the dual block HER2 assessment effectively raised the HER2 IHC positive rate. In regular clinical use in GC, we recommended that dual block HER2 testing be promoted.

Source link: https://doi.org/10.1186/s13000-022-01230-7

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions