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Mrna - PLOS

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Last Updated: 07 June 2022

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Association between history of HBV vaccine response and anti-SARS-CoV-2 spike antibody response to the BioNTech/Pfizer’s BNT162b2 mRNA SARS-CoV-2 vaccine among healthcare workers in Japan: A prospective observational study

"We wanted to see if healthcare workers with a history of poor immune response to HBV vaccination were more likely to have poor responses against the BioNTech/Pfizer BNT162b2 mRNA SARS-CoV-2 vaccine," he said. Methods: We prospectively tested 954 healthcare workers for the Anti-SARS-CoV-2 spike protein antibody antibodies prior to the first and second BNT162b2 vaccination doses and after four weeks after the second dose using Roche u2019s Elecsysu00ae assay, according to the test results. After the first BNT162b2 vaccine among HBV vaccine non-responders and poor responders in comparison to normal responders, we calculated the relative risk of non-seroconversion. Among 954 healthcare workers recruited between March 9 and March 24, 2021 at Osaka Medical and Pharmaceutical University, were among the first BNT162b2 dose responders had similar S-protein titers. Since a single dose, almost all participants seroconverted after the second dose, but some non-responders were more likely than normal responders to not seroconvert after a single dose.

Source link: https://doi.org/10.1371/journal.pone.0268529


Adverse effects following anti–COVID-19 vaccination with mRNA-based BNT162b2 are alleviated by altering the route of administration and correlate with baseline enrichment of T and NK cell genes

"The mRNA vaccines have demonstrated outstanding results among the many COVID-19 vaccines currently in use. " "The mRNA vaccines have been used in a variety of COVID-19 vaccines, and they have been used with outstanding success. " Increased expression of genes related to T and NK cell exhaustion and suppression after Pfizer-BionTech BNT162b2 vaccination increased, correlated with moderately fatigue following Pfizer-BionTech BNT162b2 vaccination, contributing to higher baseline expression of genes related to T and NK cell exhaustion and suppression at a single day post vaccination. According to this report, elevated baseline expression of T and NK cell genes raises susceptibility to fatigue after mRNA vaccination, and changing the route of vaccination could reduce the incidence of mRNA vaccine-associated systemic adverse events. ".

Source link: https://doi.org/10.1371/journal.pbio.3001643


Understanding pathogen–host interplay by expression profiles of lncRNA and mRNA in the liver of Echinococcus multilocularis -infected mice

"However, the long non-coding RNAs expression profiles of the host and the potential regulatory function of lncRNA during Em infection are poorly understood. " DELs that can influence Th17 cell differentiation and TGF-u03b2/Smad pathway of host by trans-regulating SMAD3, STAT1, and early growth response genes, according to the potential predicted function of DELs. During Em infection, Th1 and Th17-type CD4+ T-cells were present at the early infection stage, whereas Th2-type CD4+ T-cells were significantly higher at the middle/late stage. Our research found the potential regulatory roles of lncRNAs in modulating host Th cell subsets and gave novel insights into understanding Em infection-mediated host innate and adaptive immune responses. Author's comment: The growth, reproduction, and survival of Echinococcus multilocularis metacestode within the liver of the intermediate host's liver of Echinococcus multilocularis metacestode are dependent on host immune responses' dynamic control. Transcriptomic studies will likely help us to shed light on the potential role of regulatory RNA molecules in modulating the host immune response in favor of parasite survival. We compared lncRNAs and mRNAs in mice's liver after Em infection at different time points here. "Regulating SMAD3, STAT1, and early growth responses can influence differentiation of Th17 cells and TGF-1/Smad pathway of the host during the entire Em infection period. ".

Source link: https://doi.org/10.1371/journal.pntd.0010435


No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination

"We investigated two of the most widely distributed studies to see if COVID-19 mRNA vaccination of mice during early pregnancy is associated with an elevated risk of birth defects or growth abnormalities; and whether COVID-19 mRNA-vaccinated human volunteers have elevated levels of antibodies to the human placental protein syncytin-1. " We found that intramuscular COVID-19 mRNA vaccination during early pregnancy at gestational age E7. 5 did not result in differences in fetal length or weight at term, nor did we observe any gross birth defects. Severe Acute Respiratory Syndrome Coronavirus 2 and other circulating antibodies were found in these murine pregnancies prior to the establishment of the definitive placenta, showing transplacental transfer in the later stages of pregnancy after early immunization.

Source link: https://doi.org/10.1371/journal.pbio.3001506


Transcriptome-wide mapping reveals a diverse dihydrouridine landscape including mRNA

"Dihydrouridine is a modified nucleotide universally present in tRNAs, but in no organism, the complete dihydrouridine landscape is unknown. " With single-nucleotide resolution and use it to uncover new classes of dihydrouridine-containing RNA in yeast, which include mRNA and small nucleolar RNA. This research provides transcriptome-wide mapping of this RNA modification with single-nucleotide resolution, revealing dihydrouridine at new locations throughout the yeast transcriptome, suggesting a large role in folding functional RNA structures.

Source link: https://doi.org/10.1371/journal.pbio.3001622

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions