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Excess weight gain in early life can be particularly harmful by promoting earlier diabetes onset and potentially adversely affecting normal growth. In the present study, we investigated the effects of dietary fat composition on early overnutrition-induced body weight and glucose control in Swiss Webster mice, which are susceptible to high-fat diet-induced diabetes. We compared glucose homeostasis between a high-fat lard-based diet, high in saturated fats, and a high-fat olive oil/fish oil-based diet, with a high percentage of monounsaturated and omega-3 fats. However, early overnutrition HFO pups gained more weight and adiposity, and had a higher incidence of diabetes than HFL, which were lacking early overfeeding HFO pups gained more weight and adiposity, and had higher diabetes risk than HFL.
Source link: https://doi.org/10.1038/s41598-021-93409-z
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