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Participants of the Alzheimer's Disease Neuroimaging Initiative who are free of clinical dementia or stroke underwent neuropsychological evaluation and MRI testing. Adjusting for age, sex, and apolipoprotein E u025b4 frequency, the ANCOVA models were compared to cognitive groups on regional WMH adjusting for age, sex, and apolipoprotein E u025b4 frequency. Many with Obj-SCD had higher temporal, occipital, and frontal WMH, compared to the CU group, while those with MCI had higher WMH figures in all regions. No differences were found in WMH volume between the Obj-SCD and MCI groups.
Source link: https://doi.org/10.1016/j.neurobiolaging.2022.06.002
If MCI's early detection of MCI and/or its conversion to AD prevents the subsequent AD, MCI should be the top priority for AD prevention as a distinct transitional stage before the onset of AD. The most convincing evidence is that GRK5 knockout mice develop into aMCI during aging. The resultant double transgenic GAP mice with Tg2576 Swedish amyloid precursor protein transgenic mouse was seen with exaggerated behavioral and pathological changes throughout the range of AD pathogenesis.
Source link: https://doi.org/10.3233/JAD-215379
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