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Mild Cognitive Impairment - Springer Nature

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Last Updated: 28 September 2022

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DWI-based MR thermometry: could it discriminate Alzheimer’s disease from mild cognitive impairment and healthy subjects?

Purpose The aim of this research is to determine the lateral ventricular cerebrospinal fluid temperature of the patients with Alzheimer's disease, mild cognitive impairment, and healthy individuals using diffusion-weighted imaging based magnetic resonance thermometry. Study Protocols Seventy-two patients who underwent 3-T MR examination from September 2018 to August 2019 were included in this study. Patients were assessed using the Mini-Mental State Examination and the Clinical Dementia Rating score. The median MMSE score varied across groups and in pairwise comparisons. The median CSF temperature values revealed statistically significant differences between groups of participants. The post hoc Mannu2013Whitney U test showed a significant difference between AD patients and HS. Result: In AD patients, lower CSF temperatures were recorded in HS than in HS, likely due to reduced brain metabolism in AD. DWI-based MR thermometry as a noninvasive imaging technique that allows for the determination of CSF temperatures may aid in AD diagnosis.

Source link: https://doi.org/10.1007/s00234-022-02969-y


Diagnostic performance of hippocampal volumetry in Alzheimer’s disease or mild cognitive impairment: a meta-analysis

Objective The objective is to determine the diagnostic success of hippocampal volumetry for Alzheimer's disease or mild cognitive impairment. Methods The MEDLINE and Embase databases were searched for journals that assessed hippocampal volumetry in differentiating AD or MCI from normal controls, which was released up to March 6, 2022. The diagnostic results of entorhinal cortex volumetry were also pooled. Study heterogeneity was shown by MMSE scores, study design, and the reference benchmark that were used. Both AD and MCI showed a higher diagnostic success of entorhinal cortex volumetry for both AD and MCI. Entorhinal cortex volume analysis may have superior diagnostic results than hippocampal volumetry. u2022 Key Points : u2022 The pooled sensitivity and specificity of hippocampal volumetry for Alzheimer's disease were 82% and 87%, respectively, for mild cognitive impairment. u202222 Subgroup study showed superior diagnostic results for entorhinal cortex volume testing for AD and MCI.

Source link: https://doi.org/10.1007/s00330-022-08838-9


SafeMove: monitoring seniors with mild cognitive impairments using deep learning and location prediction

Seniors with such impairments may experience a slight decline in their cognitive skills, which may lead to memory loss and behavioral disorders. We introduce SafeMove, a real-time smartphone-based monitoring device that can detect and predict elderly people's activities by investigating outdoor trajectories in this paper. This is achieved by firstly reviewing the elder's mobility data that was earlier collected using the neural network SpaceTime-Convolutional Network in order to identify the most popular destinations he/she might visit in the upcoming year. In our abnormal behaviour detection system that takes advantage of recurrent neural networks, time and space-related variables, such as the distance traveled, the course of the movements, and the time spent, are investigated. Using different databases containing real-world GPS trajectories, we can assess the effectiveness and the reliability of our system for predicting the next location and reporting abnormal behaviour.

Source link: https://doi.org/10.1007/s00521-022-07320-3


A single-center, randomized, parallel design study to evaluate the efficacy of donepezil in improving visuospatial abilities in patients with mild cognitive impairment using eye-tracker: the COG-EYE study protocol for a phase II trial

Background Cholinesterrase inhibitors reduce long-term cognitive decline in patients with Alzheimer's disease and Alzheimer's disease; however, there is no evidence that ChEIs has influenced cognitive test results in patients with mild cognitive impairment. Because of this, the immediate need to refocus on direct physiological tests to determine the effects of ChEIs in patients with MCI as a result of AD is imperative. Methods We propose a controlled trial to determine the effect of donepezil, a ChEI, on patients with MCI due to AD. The differences in changes during the follow-up between the two companies' and control groups using the t-test or Mann u2013Whitney U test will be based on the difference in results during the follow-up as well as adjusting for baseline values. Discussion This article is intended to determine whether eye-tracking data can reveal the effects of donepezil on visuospatial dysfunction more accurately in patients with MCI.

Source link: https://doi.org/10.1186/s13063-022-06781-0


Quantitative gait analysis in mild cognitive impairment, dementia, and cognitively intact individuals: a cross-sectional case–control study

Background According to literature, cognitive age-related decline is attributed to dementia formation and gait, and it has been suggested to quantify brain function changes. This research was designed to see if spatiotemporal gait variables could be used to distinguish between the three cognitive status groups. The effects of cognitive stability and walking were determined by a two-way ANCOVA. Characteristics of Receiver Operating Characteristics was used to discriminate between three groups on gait variables. Conclusions There were significant differences between the MCI and dementia, as well as between dementia and cognitively intact groups walking in both single and dual-task walking in several variables between the MCI and dementia and cognitively healthy groups, however no difference was observed between the MCI and dementia groups. Conclusions In both single and dual-tasks, spatiotemporal gait variables demonstrated discriminative capability between dementia and cognitively healthy groups. This means that gait could potentially be used as a clinical differentiation indicator for people with cognitive impairments.

Source link: https://doi.org/10.1186/s12877-022-03405-9


A 'good dyadic relationship' between older couples with one having mild cognitive impairment: a Q-methodology

Background Cognitive impairment gradually adds to the relationship between senior married couples. Therefore, this report was intended to investigate couple dyadic relationship's key characteristics in the context of mild cognitive impairment, as well as whether their relationship and well-being were consistent and similar. Methods Q-methodology was used to determine the perceptions of a good dyadic relationship'u2019 among couples with one of MCI. The Q-sort was completed by Forty people with MCI and forty spousal partners. Couples with discrepant views scored significantly higher on measures of the relationship's quality and closeness with their partner. Both directions contribute to this research's increasing theoretical knowledge of the dyadic relationship between couples with one having MCI. MCI is a state in which couples can freely discuss their aspirations.

Source link: https://doi.org/10.1186/s12877-022-03449-x


Predicting conversion to Alzheimer’s disease in individuals with Mild Cognitive Impairment using clinically transferable features

Patients with Mild Cognitive Impairment have an elevated risk of Alzheimer's disease in the United States. We used longitudinal data from the ADNI database to determine a trajectory toward AD in a group of patients identified as MCI at a baseline examination. We obtained a cross-validation classification accuracy of about 70% by running two independent classification schemes within a machine learning framework, with cognitive function, hippocampal volume, and genetic APOE status as standard. Impaired memory function was consistently found to be one of the key signs of MCI patients on a path to AD.

Source link: https://doi.org/10.1038/s41598-022-18805-5


Reshaping the path of mild cognitive impairment by refining exercise prescription: a study protocol of a randomized controlled trial to understand the “what,” “for whom,” and “how” of exercise to promote cognitive function

Background Information Targeted exercise training is a promising tool for boosting cognitive function and preventing dementia in older people. Both aerobic training and resistance training improve cognitive development in older adults without cognitive impairment; however, the overwhelming majority of studies have concentrated solely on AT. Therefore, we intend to conduct a 6-month, two u00d7 two factorial controlled trial in older adults with MCI to determine the individual effects of AT and RT, as well as the combined effect of AT and RT on cognitive function, as well as the potential underlying biological mechanisms. The most important outcome is cognitive function as measured by the Alzheimer's Disease Assessment Scale-Cognitive-Plus. Understanding the feasibility of various forms and combinations of exercise training to reduce cognitive decline will improve our ability to prescribe exercise as a u201cmedicine+u201d to prevent MCI and delay the onset and progression of dementia.

Source link: https://doi.org/10.1186/s13063-022-06699-7


Metabolomic alterations in the blood plasma of older adults with mild cognitive impairment and Alzheimer’s disease (from the Nakayama Study)

Metabolomic studies have gained increasing interest, and the aim of this study was to find metabolomic biomarkers associated with AD and mild cognitive impairment. The ornithine metabolic enzymes' blood mRNA levels were also determined. In the AD group, Ornithine's level was noticeably lower in comparison to the Control and MCI groups. In the AD group, both Uracil and lysine were also significantly reduced compared to the Control group. The Barthel index score was highly correlated with lysine. The spermine synthase mRNA level in AD was significantly reduced in the ornithine metabolism pathway. In the AD group, Ornithine metabolism was decreased, and mRNA expressions related to its metabolism were changed, suggesting a correlation between abnormal ornithine metabolism and AD. Both increased betaine and reduced methionine may also be used as indicators of elevated IADL in elderly patients.

Source link: https://doi.org/10.1038/s41598-022-19670-y


Change in brain amyloid load and cognition in patients with amnestic mild cognitive impairment: a 3-year follow-up study

Background The purpose was to investigate the discriminative value of 18F-Flutemetamol PET in longitudinal studies of amyloid beta accumulation in amnestic mild cognitive impairment patients, irrespective of longitudinal demographic changes. Methods We investigated the connection between changes in brain amyloid load and cognitive stability in aMCI patients over time up to three years, allowing us to investigate potential correlations between changes in brain amyloid load and cognition as time progressed. Patients with aMCI were tested with 18F-Flutemetamol PET scan, brain MRI, and cognitive tests at baseline and after 3-year follow-up or earlier if the patient had responded to Alzheimer's disease. Results 18F-flutemetamol uptake during the sequel soared during the follow-up, and the rise was noticeably higher in patients who were amyloid positive at baseline compared to amyloid-negative ones. The increase in 18F-Flutemetamol uptake and decrease in MMSE and logical memory I scores were seen together by an association.

Source link: https://doi.org/10.1186/s13550-022-00928-5

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions