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Mild Cognitive Impairment - Europe PMC

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Last Updated: 28 January 2023

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Proteomics of serum exosomes identified fibulin-1 as a novel biomarker for mild cognitive impairment.

Mild cognitive impairment is a predictor of Alzheimer's disease pathology. Cognitive impairment patients commonly have a delayed diagnosis because there are no early symptoms or conventional diagnostic techniques. Correlation of cognitive function with the serum exosomal protein level was established. MCI patients had a higher serum exosome concentration and smaller exosome diameter, according to a Nanoparticle tracking study, with a greater serum exosome concentration and smaller exosome diameter than healthy controls. Using mass spectrometry analysis, we found 69 exosomal proteins that were differentially expressed between MCI patients and healthy controls. In MCI patients, Thirty-nine exosomal proteins were upregulated relative to those in control patients. Exosomal fibulin-1, with a region under the curve value of 0. 81, may be a biomarker for an MCI diagnosis. The cell adhesion molecule type was represented by the exosomal protein signature from MCI patients. In particular, higher exosomal fibulin-1 levels were correlated with lower cognitive function.

Source link: https://europepmc.org/article/MED/36018182


An Outpatient-Based Training Program Improves Family Caregivers' Preparedness in Caring for Persons With Mild Cognitive Impairment: A Randomized Controlled Trial.

Background Information Little is known about the effects of educational services on family caregivers of seniors with mild cognitive impairment in the various studies in the literature because of the significant differences in outcome variables reported in the various studies. The result at the third posttest was shown to be significantly less prepared than the control group and more capable than the control group at baseline and more confident than the control group at all three posttests, with the difference at the third posttest showing statistical significance. Conclusions The training intervention in this research was found to increase the perceived readiness of the family caregiver participants to cope with various aspects of providing services to people with mild cognitive impairment.

Source link: https://europepmc.org/article/MED/36692834


Effect of 3D-MOT training on the execution of manual dexterity skills in a population of older adults with mild cognitive impairment and mild dementia.

Computerized cognitive learning aids are a cost-effective alternative to preventive therapies related to cognitive decline and aging. The transfer of 3D multiple object tracking software on manual dexterity in 38 elderly patients was investigated in this research, half of them with mild cognitive impairment and the other half with mild dementia. The Montreal Cognitive Assessment survey was used to determine the participants's baseline cognitive status. The experimental findings show the effects of cognitive training on the development of motor skills in older adults.

Source link: https://europepmc.org/article/MED/36697411


Accelerometer-measured physical activity and sitting with incident mild cognitive impairment or probable dementia among older women.

Introduction Physical fitness is inversely linked to dementia risk, but no studies have investigated accelerometer measurements of PA and sitting in areas with rigorously-adjudicated mild cognitive impairment and dementia risk. Methods We investigated the correlations of accelerometer measurements with event MCI/probable dementia in the Women's Health Initiative in the Women's Health Initiative over a median follow-up of 4. 2 years, 267 MCI/probable dementia cases were reported. According to the results, u2265 moderate intensity PA, especially stepping, is associated with reduced MCI and dementia risk. To reduce ADRD risk among older women, moderate physical fitness may be required.

Source link: https://europepmc.org/article/MED/36695426


The combination of hyperventilation test and graph theory parameters to characterize EEG changes in mild cognitive impairment (MCI) condition.

The Mild Cognitive Impairment prodromal to Alzheimer's disease's main aim is to investigate the efficiency of HV tests in improving functional connectivity from the EEG signals that can be indicative of a prodromal state of Alzheimer's disease's precursors. Since the cognitive decline in MCI seems to be a progressive disconnection syndrome, the current study's methodology, which allows us to characterize brain networks with a variety of variables, is graph theory. All three graph variables, as measured in the standard EEG frequency bands, showed significant shifts between the three groups, but more interestingly, a significant difference in the GE values between the MCI group and the Ctrl one was established, indicating that the combination of HV test and graph theory parameters could be a powerful tool for the detection of potential cerebral dysfunction and alteration.

Source link: https://europepmc.org/article/MED/36692591


Error monitoring in amnestic mild cognitive impairment: Cognitive correlates and relationship to measures of everyday function.

This report investigated how error recognition is affected by amnestic mild cognitive impairment in comparison to cognitively healthy older adults. Method Twenty-four people with aMCI and 24 cognitively HOAs completed standardized cognitive assessments; a computerized go-no-goo paradigm test that standardized error detection; a pragmatic, results-based assessment of everyday activities; and self- and informant-report measures of everyday dysexecutive difficulties; and quantitative measures of daily dysexecutive difficulties; and, eight people with aMCI and 24 cognitively HOAs completed standardized cognitive assessments; and, Participants with aMCI demonstrated noticeably poorer error monitoring in comparison to the HOA group. Conclusions Compared to HOAs, people with aMCI had less apparent errors alerts. If individuals with aMCI have trouble recognizing accuracy, they will be unable to rectify their mistakes, resulting in delays in everyday tasks completion and difficulty in implementing appropriate compensatory techniques. According to results, error monitoring may be a potential point for intervention with people with aMCI.

Source link: https://europepmc.org/article/MED/36689394


Diffusion Kurtosis Imaging in Evaluating the Mild Cognitive Impairment of Occupational Aluminum Workers.

Rationale and goals: To determine whether diffusion kurtosis imaging can detect mild cognitive impairment in aluminum-exposed workers and aluminum-exposed workers, as well as exploring the connection of DKI with cognitive function and plasma Al concentration, see Figures. Using Spearman correlation analysis, the relationship between parameter values and cognitive success and plasma Al concentration was investigated. The MK, Kr, MD, and FA scores were correlated with the Montreal Cognitive Assessment results, and MK values in the right hippocampus showed the highest correlation with MoCA ratings, according to MoCA results. Plasma Al in the MCI group was higher than that in the NC group, although there was no significant difference in plasma Al between the two groups compared to the NC group, although there was no significant difference in plasma Al between the two groups. Conclusion The DKI method can be used to discriminate MCI from NC, and it could be used to preliminarily determine cognitive impairment in Al-exposed workers.

Source link: https://europepmc.org/article/MED/36690563


A systematic review of the health effects of yoga for people with mild cognitive impairment and dementia.

Background Yoga is a mind-body exercise that can have pronounced health and wellbeing benefits for older adults. As a result, public and academic curiosity in the potential benefits of yoga for older people with mild cognitive impairment and dementia has risen. Methods Literature searches in five databases were conducted from the databases' inception to the date of inception and into early September 2020 to identify pre-post single and multigroup studies of yoga-based programs involving people with MCI or dementia. Two of the four studies used Kundalini yoga and chair yoga, while two others used Hatha yoga. Yoga classes were offered for 12 weeks and compared yoga to a control group. Conclusions These studies show that yoga may be safe and beneficial for people with MCI or dementia. To expand the evidence base and overcome the limitations of current studies, more high-quality randomised controlled trials are required.

Source link: https://europepmc.org/article/MED/36670348


Spatiotemporal gait parameter fluctuations in older adults affected by mild cognitive impairment: comparisons among three cognitive dual-task tests

Backgrounds: : Gait disorder is a result of cognitive impairment, and when doing additional cognitive tasks, it becomes more apparent. Our aim was to identify gait disorders in mild cognitive impairment under three separate tasks and find the relationship between gait endurance and cognitive function in three separate tasks. In LASSO regression, the Top 5 gait features in random forest and 46 important attributes were selected. Temporal gait parameters were among Robust variables correlated with cognitive function, associating with cognitive function. Participants in MCI showed reduced swing time and terminal swing, increased mid stance, and even variation of stride length in comparison to normal controls. Word recall administered a greater effect on gait regularity, velocity, and dual task cost in the three separate assessments than the other two cognitive assessments. Gait analysis under varied work conditions, particularly in the words recall test, might be a helpful adjunct to detecting MCI early in the process.

Source link: https://europepmc.org/article/PPR/PPR600597


What Tools Can We Use to Screen for Fall Risk in Older Patients With Mild Cognitive Impairment? Findings From the MEMENTO Cohort.

Objects: Identifying risk factors for falls can improve outcomes in older patients with no cognitive impairment. Despite this, it has not been demonstrated in older people with mild cognitive impairment. Setting and participants We included older people with MCI and a Short Physical Performance Battery score at baseline. Participants had fallen at least once during the study's two-year follow-up period, according to Methods Fallers, who had fallen at least once. Executive function was significantly worse in fallsers and the subgroup of men in a multivariable study, particularly in fallers than in nonfallers. Conclusion and implications The results show that simple attainable risk factors can be used to identify individuals with MCI at a higher risk of falls and for whom prevention may be helpful. Future studies are required to investigate the role of mild executive dysfunction in certain subgroups, such as men and elderly patients, where gentle executive dysfunction is present in some subgroups, such as male and elderly patients.

Source link: https://europepmc.org/article/MED/36682387

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions