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In 56 participants with PD, this prospective, longitudinal research looked at the correlations between NREM quantitative sleep electroencephalography and cognition. In a subset of 26 participants, the Sleep qEEG findings included slow wave density, spindle density, and SW-spindle coupling, measured cross-sectionally and as longitudinal predictors of PD-MCI. These results show that sleep qEEG measures can help identify individuals at risk of PD-MCI. Thus, spindles and SW have the ability to help optimize clinical trial populations and tailor clinical care.
Source link: https://doi.org/10.21203/rs.3.rs-1970916/v1
Abstract Background Myelin loss is a symptom of cerebral small vessel disease. Although physical activity can have protective effects over cSVD pathology, people living with the cSVD are unaware of its connection with myelin content. Also, we investigated whether physical activity levels in community-dwelling older adults with cSVD and mild cognitive impairment. Methods were analyzed cross-sectional data from 102 people with cSVD and mild cognitive impairment were examined for cross-sectional data. Using the Physical Activity Scale for the Elderly, physical fitness was estimated. Including myelin content in the corpus callosum's sagittal stratum, anterior corona radiata, and genu of the corpus callosum, increased physical fitness was also associated with increased physical fitness. Conclusions: Physical fitness may be a way to maintain myelin in older adults with cSVD and mild cognitive impairment. To determine if exercise raises myelin levels, future randomized controlled trials of exercise are required.
Source link: https://doi.org/10.1093/gerona/glac149
Background and Objective This was a multicenter research aimed at discovering the prevalence of cognitive decline, neuropsychiatric signs, and brain imaging in people with subjective cognitive decline and subtle cognitive decline. In 45 percent of participants and revealed brain hypometabolism in 55%, with a frontal-like pattern as the most common finding. The Neuropsychiatric Inventory and the Starkstein Apathy Scale were both highly prevalent in the whole sample. In the 18% of participants who underwent amyloid PET, an abnormal amyloid load was found. Two factors emerged from the neuropsychiatric PCA's effect, correlating with hypometabolism in orbitofrontal and insula; hyperactive/psychotic, correlated with hypometabolism in frontal, temporal, and parietal areas; and parietal regions. Review of FDG-PET results in SCD and pre-u2013MCI show either normal brain function or different patterns of brain hypometabolism. These results show that SCD and pre-u2013MCI represent heterogeneous populations.
Source link: https://doi.org/10.1212/wnl.0000000000200351
Regular exercise has been shown to be one of the most important lifestyle factors on improving functional efficiency and reducing morbidity and all-cause mortality among senior citizens. However, although there is some evidence relating to aerobic exercise's antioxidant stress, there is no information about multicomponent exercise and a blend of exercise with cognitive stimulation on oxidative stress. The aim of this analysis was to investigate the effects of a multicomponent exercise regimen on physical fitness and cognitive function in elderly people with mild cognitive impairment, as well as identify the role of oxidative stress and brain-derived neurotrophic factor. At baseline, 37 elderly nursing home residents with mild cognitive impairment were divided into two groups: the control group and the experimental group. The findings show that multicomponent exercise training increases functional capacity and reduces damage due to oxidative stress.
Source link: https://doi.org/10.3389/fnagi.2022.950937
According to previous studies, regular exercise may reduce dementia symptoms progression. Objectives Objectives: Objectives In comparison to standard care, the clinical relevance and cost-effectiveness of a bespoke exercise program could be determined on the cognitive impairment, function, and health-related quality of life of people with mild to moderate dementia, carer burden, and HRQoL. Participants People with MMD live in the community. The biggest outcomes for Carer were HRQoL and carer burden. From a NHS and Personal Social Services perspective, the economic analysis was based on incremental cost per quality-adjusted life-year gained from a health-care perspective. With the Client Services Receipt Inventory, we tracked health and social care use. For the EQ-5D-3L, a mean difference of 0. 6 versus the NPI was not reported; there were no treatment effects for any of the other secondary outcome measures for participants or carers: for the EQ-5D-3L a mean difference of 0. 6 versus u20132. 1, a difference of 0. 6 is the difference between participants or carers, but there were no treatment effects for any of the other secondary outcome measures, including the NPI, a difference of a Future work To influence cognitive impairment in dementia, cognitive impairment should be influenced by diet other than exercise. Funding This project was supported by the National Institute for Health Research Health Technology Assessment program and will be published in full as part of Health Technology Assessment Vol. 92 (Health Research Assessment Vol. 7) and will be published in full in Health Technology Assessment Vol. 11. The Oxford NIHR Biomedical Research Centre and the Oxford NIHR Collaboration for Leadership in Applied Health Research and Care each received additional funds from the Oxford NIHR Biomedical Research Centre and the Oxford NIHR Collaboration for Leadership in Applied Health Research and Care.
Source link: https://doi.org/10.3310/hta22280
This report is designed to compare the effects of multitask and multicomponent training on processing speed, cognitive skills, gait speed, and balance in people with mild cognitive impairment. Following training, processing speed, cognitive skills, gait speed, and balance skills increased in the MTT and MCT groups, with no significant differences between the groups in processing speed or cognitive tasks. MTT and MCT strategies can be used to enhance cognitive and physical fitness in people with moderate cognitive impairment.
Source link: https://doi.org/10.1123/japa.2021-0408
Using the floor maze test, this research sought to investigate the relationship between physical fitness and spatial navigation in older adults with mild cognitive impairment and healthy controls. In the floor maze test, mobility and aerobic capacity were both associated with later maze time. Spatial navigation is also associated with patients with mild cognitive impairment and healthy older adults.
Source link: https://doi.org/10.1123/japa.2021-0168
Purpose: To determine the clinical safety of Idebenone in stroke patients with mild cognitive impairment, as well as its impact on regional homogeneity of resting-state functional magnetic resonance imaging of the brain. Methods: The China Rehabilitation Research Center in Beijing Boai Hospital's January 2018 to January 2020 cohorts included one hundred and twenty stroke patients with mild cognitive impairment who were admitted to the Department of Neurology from January 2018 to January 2020. There were significantly more patients with improved clinical dementia scores in the study group after 6 months of observation than in the control group. Conclusion: Because of improved brain functioning in the precuneus, the use of idebenone and nimodipine for treating stroke patients with cognitive dysfunction leads to significant improvements in clinical outcomes, as well as an increase in cognitive function and quality of life.
Source link: https://doi.org/10.4314/tjpr.v21i7.28
Methods We present here the total plasma apoE and apoE isoform levels at baseline from a longitudinally followed cohort, patients with amnestic mild cognitive impairment during 24 months follow-up, patients with amnestic MCI during comparison, patients with dementia and patients with dementia were clinically diagnosed with dementia and patients with dementia at baseline. We further investigated the links between plasma apoE levels with cerebrospinal fluid AD biomarkers and u03b1-synuclein, as well as both CSF and plasma neurofilament light chains, YKL-40 and kallikrein 6. Low plasma apoE and low CSF A03b2 42's were also linked to higher blood tau and tau phosphorylated in Thyonine 181 residue and NfL, as well as a poor showing at the mini-mental state examination.
Source link: https://doi.org/10.1186/s13195-022-01058-9
Abstract Objective Objective: The aim of this paper is to investigate the incidence, influencing factors, and population distribution of AD and MCI among Hubei province residents aged 60 years or older. In a case-control study, the screened patients with AD and MCI were then selected as patients. According to the survey, AD and MCI were between 1. 4 percent and 10. 04%, respectively. Infrequent participation in social activities, etc;; and infrequent communication with children, etc. were all potential causes for AD and MCI separately. Conclusions The incidence of AD 60 and over in Hubei province was lower than the national average of 3. 0 percent. AD and MCI were influenced by their social networks, lifestyle habits, and so on, among other things. The elderly people should be encouraged to research and collaborate with others, partake in regular physical fitness, and adopt a healthier lifestyle in order to delay or slow cognitive decline.
Source link: https://doi.org/10.21203/rs.3.rs-1690951/v1
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