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Mild Cognitive Impairment - ClinicalTrials.gov

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Last Updated: 28 September 2022

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Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment

Brain stimulation is thought to improve efficiency in the targeted brain regions/networks, thus increasing the patients' ability to profit from memory rehabilitation. The primary aim of this research is to investigate the effects of two specific types of memory loss therapies in people with mild cognitive impairment. Cognitive therapy, which involves teaching new ways to learn and recall information, is one form of therapy. To increase activity in certain brain regions that may be related to memory, the second type of therapy uses transcranial direct current stimulation. We'll use brain imaging to see if these therapies changed how people learn and remember information. Cognitive tests and questionnaires will also be used to see if memory changed as a result of therapy.

Source link: https://clinicaltrials.gov/ct2/show/NCT02155946


Reshaping the Path Post Hip Fracture in Mild Cognitive Impairment

Many with fall-related hip fractures have cognitive impairment, and they are less likely to recover pre-fracture functionality than those without cognitive impairment. The goal of this 6-month proof-of-concept RCT is to determine the effectiveness of the home-based Otago Exercise Program in comparison with standard care in reducing fall risk among community-dwelling seniors with MCI and a fall-related hip fracture.

Source link: https://clinicaltrials.gov/ct2/show/NCT04748354


Walking Interventions, Cognitive Remediation and Mild Cognitive Impairment

This is a single blind randomised research that aims to investigate the effects of various interventions, walking programs, and cognitive rehabilitation, in particular, on elderly people's cognition and gait. The investigators will look at the effects of each intervention on cognitive function and gait. Objective clinical results related to dementia will be included in clinic and "free living" measures related to falls.

Source link: https://clinicaltrials.gov/ct2/show/NCT01801943


Changing the Trajectory of Mild Cognitive Impairment With CPAP Treatment of Obstructive Sleep Apnea

According to an increasing number of new studies, obstructive sleep apnea, which is characterized by episodic nocturnal destruction of the upper airway and impairment/cessation of breathing leading to significant nocturnal hypoxia, is associated with an elevated risk of cognitive impairment. The n=460 divided into three groups will be divided into three groups for one year, with 2b a no apnea control group approximately n=100. This will allow us to determine whether CPAP therapy, accounting for risk factors such as neuroimaging results and OSA severity at baseline, would determine the primary outcome of cognitive function at a 1-year follow-up. In aMCI and OSA, this research will also investigate the one-year effects of CPAP on cognitive stability and establish physiological mechanisms for cognitive decline.

Source link: https://clinicaltrials.gov/ct2/show/NCT03113461


Effect of Tablet-Based Games on Executive Functions in Older Adults With Mild Cognitive Impairment

Mild Cognitive Impairment (Mild Cognitive Impairment): The aim of this report is to investigate the use of tablet-based video games as a means of enhancing executive functioning in senior adults with Mild Cognitive Impairment. Many studies point to the use of cognitive therapies as a means of improving general cognition in older adults. Video games can be more cost effective than traditional cognitive therapies because they are challenging and fun, offer regular feedback that motivates and encourages user participation, and are widely available on tablet devices at low cost. For a week, one of the forty-two older adults with Mild Cognitive Impairment, as well as their study partner, will be randomly selected to play either a role-playing game or a series of word or image puzzles.

Source link: https://clinicaltrials.gov/ct2/show/NCT05468424


Spironolactone Safety in African Americans With Mild Cognitive Impairment and Early Alzheimer's Disease

In 2018, 5. 5 million older adults in the United States were diagnosed with Alzheimer's disease, and by 2060, 15 million people will be diagnosed with dementia, including Alzheimer's disease. Compared to Whites, elderly African American adults in senior-advance are more likely to be diagnosed with Alzheimer's disease than in Whites. According to research, African Americans have elevated blood pressure and blood vessels that can be involved with regulation of blood pressure and blood vessels. Increases in blood vessels in the brain as a result of higher aldosterone levels are also attributed to changes in thinking skills and memory, according to research findings. Spironolactone is a drug that blocks aldosterone and has been used to treat elevated blood pressure for 60 years. This drug has been shown to have the ability to reduce declines in reasoning skills and memory, as well as cognitive declines. This study, as such, is designed to see how a small group of elderly African Americans with mild cognitive impairment would tolerate the drug. Persons who register to participate in the study and request to participate will be given spironolactone or a placebo and be monitored for drug side effects for one year. The findings of this report may support the larger study of spironolactone in older African Americans with mild cognitive impairment. As people age, the findings from this research will determine a racial difference in Alzheimer's disease and maintain the brain's health.

Source link: https://clinicaltrials.gov/ct2/show/NCT04522739


Evaluating the Retinal Microvasculature in Mild Cognitive Impairment and Alzheimer's Disease Using Optical Coherence Tomography Angiography

The investigators intend to investigate signs of reduced capillary blood flow and non-perfusion in the superficial and deep retinal plexuses and choriocapillaris of OCTA, a resolution not previously available, to extend their sensitivity and specificity in the early detection of MCI and AD, multiple sclerosis, Huntington's disease, and Huntington's disease using advanced image processing. This report provides evidence of concept for OCTA-based retinal microvascular biomarkers as an excellent screening device for cognitive age.

Source link: https://clinicaltrials.gov/ct2/show/NCT03233646


The Effects of an Agility Training and Its Relation to Motor, Cognitive Performance and Fall Risk in Elderly Adults With and Without Mild Cognitive Impairment

The following three-part report will explore agility training's effects as well as the connection between agility skill and motor and cognitive development, as well as the danger of falls in elderly adults with or without mild cognitive impairment. Part I of a cross-sectional research design that will determine the effect of aging and cognition decline on agility, cognition, and motor skills in healthy young adults, healthy elderly adults, and elderly adults with MCI. Cognitive function assessments include assessments of global awareness, working memory, mental agility, and selective attention. All tests will be used to determine the motor, cognitive, and other predictive factors associated with agility success, and will be used in the development of the training program in Part II and III. Multicomponent training and an agility, motor, and cognitive skills in elderly adults with and without MCI are single-blinded controlled trials that will investigate the short and long-term effects of a multicomponent training and an agility training protocol on agility, motor, and cognitive development in elderly adults with and without MCI. The agility test, cognitive assessments, and single and dual task walking tests using fNIRS will be tested. Each training session comprised of agility's determining factors of agility will feature 3 to 4 exercises, and the agility training group will enroll in integrated task-specific training. After the intervention and a one-month follow-up after training, the healthy elderly adults will be assessed.

Source link: https://clinicaltrials.gov/ct2/show/NCT05537363


The Effect of Transcranial Direct Current Stimulation on Visual Attention in Mild Cognitive Impairment - a Combined MRI and Non-invasive Brain Stimulation Study

In the MCI-AD, the investigator will investigate the long-term effects of ten active tDCS consecutive sessions using an enhanced stimulation protocol as compared to a placebo stimulus on visual attention. After the conclusion of the last stimulation session, behavioral analysis of the trained job and the transfer task will be repeated and again immediately after and again at a one-month follow-up visit.

Source link: https://clinicaltrials.gov/ct2/show/NCT03974087

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions