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Patients with MCI will be included in this research, and results will be collected in the baseline, including demographics, clinical findings, neuropsychology, electrophysiology, neuroelectrophysiology, blood samples, cerebrospinal fluid, etc. The subjects were divided into MCI progression and MCI stabilization, according to the neuropsychological evaluation findings of a follow-up, and MCI stabilization. Some neuropsychological scales included in patients with MCI, such as: Clinical Dementia Rating, Mini-Mental State Examination, Montreal Cognitive Assessment, etc. , were among the neuropsychological tests administered. tau-PET and tau-PET are among the candidate neuroimaging markers on display and functional brain magnetic resonance imaging, Diffusion tensor image, and 18 F-2-fluro-phosphate-positron emission tomography, including structure and functional brain magnetic resonance imaging, 18 F-2-fluro-positron emission tomography uff0cAmyloid-PET and tau-PET. The biomarkers and their combinations from MCI transmission to dementia can be obtained using statistics and machine learning techniques, and it can play a role in the development of a risk prediction model and a prompt warning evaluation system for MCI transmit to dementia.
Source link: https://clinicaltrials.gov/ct2/show/NCT05697588
Two-arm, single-blind, pilot placebo controlled trial at two VA medical centers will be used to carry out the study. In a 1:1 ratio to either the MiND-MCI group or the waitlist control group, eighty participants at each location will be randomly assigned in a 1:1 ratio to either the MiND-MCI group or a waitlist control group. Participants will include veterans 60 and older with a diagnosis of MCI, at least one cardiovascular risk factor, self-reported cognitive impairment, and self-reported difficulty in responding to MCI diagnosis or symptoms.
Source link: https://clinicaltrials.gov/ct2/show/NCT05690243
Repeated transcranial magnetic stimulation has improved global cognitive performance and daily living, according to early studies in Alzheimer's disease dementia patients. Given that there are adequate neuroplasticity in AD, neuronal decay, and synaptic dysfunction in brain networks, the findings of these early studies of brain stimulation show that there are sufficient neuroplasticity in AD for effective effects of brain stimulation. Importantly, when other researchers used rTMS to stimulate a lateral parietal cortical site in healthy young adults, the effects of rTMS on memory were apparent weeks later. DLPFC and LPC are two typical rTMS treatment groups, since the DLPFC and the LPC stimulations may have distinct effects, we planned this pilot trial to feature two active rTMS treatment groups: DLPFC and LPC. Active rTMS will outlast inactive rTMS in memory enhancements, according to the primary hypothesis. Measures of improvement in functional connectivity will be tested to see if there are signs that the PCC's connectivity with other areas of the brain can be determined. Genetic markers that measure heterogeneity of response will be collected in addition to investigating the effects of rTMS on functional connectivity and cognition in relation to the cortical site stimulated. Participants will be followed longer than in any previous study to determine the tenability of rTMS effects on memory. If this report shows that rTMS improves memory in older adults with MCI, it could potentially lead to more clinically and successfully treating millions of older adults with MCI and are at a higher risk of developing dementia.
Source link: https://clinicaltrials.gov/ct2/show/NCT03331796
Following a treatment protocol designed to foster learning, the investigators discovered an improvement in MCI with documented cognitive impairment through a small randomized clinical trial. The new report will expand on this research and investigate the effects of the therapy on everyday life, the long-term safety of the therapy, and the use of booster sessions in enhancing long-term treatment effects. We'll randomly assign older people who meet the requirements for an amnestic MCI diagnosis to a memory retraining group or a placebo control group. Through the assessment of cognitive function by a standard evaluation, the investigators will be able to determine the effectiveness of this particular memory retraining procedure in an aMCI population.
Source link: https://clinicaltrials.gov/ct2/show/NCT05396248
Mild cognitive impairment is a stage between the predicted cognitive decline of normal aging and Alzheimer's disease-related dementia. About 20% of older adults in the United States have MCI, and about 15% of those with MCI have MCI will move to AD. Impaired cognitive function in aging can have far-reaching and tragic effects on functioning, resilience, and overall quality of life. MCI's older adults with MCI double-task training that involves simultaneous cognitive and motor challenges improves certain domains of both cognitive and motor function. With MCI, one test determines the possibility of implementing a community-based dual-task analysis while still doing physical fitness training; two others investigate the impact of dual-task training on attention and motor function among adults, 65 years or older; and 2 examine the effects of dual-task training on attention and motor function among adults, 65 years or older.
Source link: https://clinicaltrials.gov/ct2/show/NCT04059705
Those with MCI also have poor standing balance results, i. e. the ability to maintain equilibrium when standing and simultaneously doing unrelated cognitive task. According to a recent report by our lab, standing reduces fronto-central alpha power, i. e. , changes in the 8-13 Hz band, and 2 others with lower fronto-central alpha power when dual tasking experience poor dual task standing balance. TACS is a non-invasive brain stimulation device that uses low-amplitude alternating currents to regulate brain function and entrain specific cortical rhythms based on the application frequency. Participants will be tested both standing and cognitive assessments immediately before and after single sessions of ten-task alpha stimulation tACS fronto-central alpha stimulation, as well as active-sham to determine the effect of different stimulation settings on dual-task standing results in older adults. Following a decrease in pre-to-post tACS in older adults with and without MCI, we suspect 1 older adults with MCI will have reduced EEG alpha power during dual-tasking, worse balance results during dual-tasking, and 2 compared to pre-stimulation.
Source link: https://clinicaltrials.gov/ct2/show/NCT05680701
Mild Cognitive Impairment, a medical condition that includes age-related cognitive impairment, and dementia-related cognitive disorders, represents the advanced stage of a syndrome spectrum of cognitive decline, as well as age-associated neurodegenerative disorder, and Mild Cognitive Impairment, a clinical disorder that includes memory and cognitive impairment, but no significant functional impairment must be present to meet threshold criteria for dementia diagnosis. MetS is a collection of cardiovascular risk factors related to central obesity, including impaired glucose metabolism, dyslipidaemia, and elevated BP, which are all associated with an elevated risk of both Type 2 Diabetes Mellitus and coronary artery disease. Insulin resistance in MCI and dementia Insulin and insulin resistance Insulin resistance, synaptic maintenance, beta-amyloid control, and tau phosphorylation are all important aspects and functions of age-related neurodegenerative diseases, including glucose metabolism, vascular function, synaptic maintenance, tau phosphorylation, and tau phosphorylation. Both hyperglycaemia and insulin resistance IR have also been shown in population-based studies to be related to reduced cognitive function in older people. Several mechanisms are likely to account for the rise in the risk of cognitive impairment in T2D. Insulin resistance, as mentioned above, has been shown to play a key role in cognitive decline in people with type 2 diabetes T2D. Moreover, chronic hyperglycemia has been shown to be associated with reduced cerebral blood flow, reduced glucose transport across the blood brain barrier, improved cerebral glucose metabolism, and microvascular damage caused by endothelial damage. Insulin resistance, Lowering Insulin Resistance Lowering Insulin Resistance As potential treatments for AD, Recent studies point to the discovery of insulin receptors and, specifically, the lowering of insulin resistance as potential AD treatments. Population of China patients are included in this new clinical trial, which also uses the populations of our on-going Singapore Longitudinal Ageing Studies SLAS Study, where only Chinese Patients are included. 360 Chinese patients with prediabetes or diabetes with MCI will be identified and recruited from the community and primary care clinics in the Singapore Longitudinal Ageing Study SLAS-1 cohort and SLAS-2 cohort in the South West Region. Younger patients IRMCI-1 or untreated type 2 diabetes IRMCI-2 or older patients with amnestic MCI or non-amnestic multi-domain MCI will be randomly selected within Apolipoprotein E4 positive and ApoE4 negative strata to the IRMCI-2 older patients, according to the IRMCI-1 positive and ApoE4 negative strata: Active Intervention Intensive lifestyle modification or Control group standard lifestyle guidelines. Using the Mini mental State Examination MMSE and Montreal Cognitive Assessment Scale, Executive function, Visual-Spatial and Constructional ability, and Attention are used in various cognitive domains, as well as a comprehensive Neuropsychological Test Battery that will assess results on several cognitive domains Memory, Story Memory, Language, Executive function, Visual-Spatial and Constructional ability and Attention. According to the Clinical Dementia Rating CDR scale, subjects with age-and education-adjusted MMSE 26 or MOCA 26 or more than average deviation from age-and-education adjusted norms are classified as "1. 0 Standard Deviation SD or more than age-education adjusted averages. According to a standard SLAS procedure that was previously used for the assessment and diagnosis of MCI and dementia, subjects with a CDR global score of 0. 5 together with Sum of Boxes of u22653 or global score of u22651 denoting dementia undergo intensive clinical evaluation including neurologic analysis, laboratory tests, and final analysis by an expert panel of neurologists and psychiatrists for final diagnosis and classification of MCI. B Prediabetic-APOE4+ and A Prediabetic-APOE4- are both divided into B Prediabetic-APOE4+ and A Prediabetic-APOE4-. The Diabetic group will also be divided into D Diabetic-APOE4+ and C Diabetic-APOE4-, respectively. Each of these four groups, A, B, C, & D, will have their individual list of 360 randomization numbers generated by NUS Research Fellow using the SAS computer software. Trained nurses will then divide patients into medical or control arm using the treatment allocations established within the serially allotted sealed envelopes.
Source link: https://clinicaltrials.gov/ct2/show/NCT02409238
High-definition transcranial direct current stimulation is particularly targeted in the region surrounded by its 4 x 1 ring of elctrodes, such that the targeted area is more susceptible to neuroplastic change than tDCS. According to research, tDCS improve cognition, memory recall, verbal fluency, and executive function. In patients with mild cognitive impairment, the aim of this report is to determine whether HD-tDCS may improve global cognitive function and sub-domains of cognition, mood, and subjective memory impairment in patients with mild cognitive impairment.
Source link: https://clinicaltrials.gov/ct2/show/NCT04121156
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