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Migraine - U.S. Department of Veterans Affairs

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Last Updated: 22 April 2022

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Peripherally administered calcitonin gene-related peptide induces spontaneous pain in mice: implications for migraine.

A trigeminal nerve hypersensitivity and photosensitivity in migraine is thought to be related to trigeminal nerve hypersensitivity and photosensitivity in migraine, but no concrete role has been identified in migraine headaches. We conclude in this review that peripherally administered CGRP may act in a light-independent manner to produce spontaneous pain in mice that is usually depicted as a facial grimace. We created a squint assay using a video-based measurement of the eyelid fissure, which revealed a significant squint reaction after CGRP injection, both in absolute darkness and in brilliant light. These findings reveal that CGRP can cause spontaneous pain in the absence of light, as well as in the absence of light, and that the squint response provides an objective biomarker for CGRP-induced pain that is translatable to humans.

Source link: https://doi.org/10.1097/j.pain.0000000000001337


Induction of Migraine-Like Photophobic Behavior in Mice by Both Peripheral and Central CGRP Mechanisms.

Although migraine can be controlled with CGRP antagonists that act peripherally, the actual locations of CGRP action remain unclear. Results in light-aversive activity in wild-type CD1 mice similar to aversion seen before after central injection. Following intraperitoneal CGRP, motility was reduced in the dark only, similar to motility changes after intracerebroventricular CGRP. We used transgenic CGRP receptor hRAMP1 subunits in nervous tissue to start investigating the mechanism of peripheral CGRP action. Surprisingly, sensitivity to low light was not apparent after intraperitoneal CGRP injection, but it was seen after intracerebroventricular CGRP injection. These findings show that CGRP can play in both the periphery and the brain by distinct mechanisms, and that CGRP's activities can be broadcast to the CNS by indirect sensitization of peripheral nerves.

Source link: https://doi.org/10.1523/JNEUROSCI.2967-16.2016


Increase in migraine diagnoses and guideline-concordant treatment in veterans, 2004-2012.

Background and purpose: While reducing unnecessary use of opioid- and barbiturate-containing medications, health care researchers, policy makers, and educators have attempted to raise guideline adherence to migraine medications. We reviewed the prevalence of migraines and proportion of guideline-conservant care in a large, national health care system over time. Methods We conducted a time-series analysis using records from the Veterans Health Administration's electronic health registry. Results A total of 57,064 veterans were diagnosed with migraine headache, with women being significantly more likely to be diagnosed. The number of veterans with migraine has dramatically increased over the years. Triptans were prescribed to 43% of people with migraine by 2012, with no difference between gender. After controlling for age, sex, race, and comorbidities treated with medications used for migraine prevention, migraine prevention showed a significant increase during the year of migraine diagnosis.

Source link: https://doi.org/10.1177/0333102416631959

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions