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MicroRNA - PLOS

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Last Updated: 23 April 2022

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The regulation of HBP1, SIRT1, and SREBP-1c genes and the related microRNAs in non-alcoholic fatty liver rats: The association with the folic acid anti-steatosis

In rats with non-alcoholic fatty liver disease, our current research looked at the possibility of ameliorative potency of folic acid and its relationship with the hepatic miR-21, -122a, and -122 expression, as well as their target genes, HBP1, SIRT1, and SREBP-1c. A total of 50 Wistar rats were randomly divided into two groups, a control group and a NAFL group. Rats in the NAFL group were fed a high-fat diet with 20% fats for 14 weeks. In the pattern of miR-21, -34a, and -122 expression, as well as their target genes in the liver, NAFL rats displayed the classic characteristics of fatty liver disease profile and dysregulation in the pattern of miR-21, -122 and -122 expression, as well as their target genes in the liver. In conclusion, the anti-steatotic, insulin-sensitizing, glucose-lowering, and lipotropic potencies of folic acid in NAFL rats may be attributed to the epigenetic modulation of the hepatic microRNAs and the expression of their target genes.

Source link: https://doi.org/10.1371/journal.pone.0265455


Expression characteristics and interaction networks of microRNAs in spleen tissues of grass carp ( Ctenopharyngodon idella )

However, miRNA expression profiles and their interaction networks associated with the postnatal late development of spleen tissue are still unclear in fish. In China, the grass carp is a key economic aquaculture species. The expression patterns of miRNAs in the spleen of one-year-old and three-year-old grass carp were highly consistent, and the percentage of miRNAs with TPM > 59 was above 49%. During normal spleen tissue formation in the late developmental stages of grass carp, this research determined the miRNA transcriptome as well as miRNA-mRNA intercellular networks. The findings extend the number of identified miRNAs in grass carp and serve as a valuable resource for better understanding the spleen development in grass carp molecular biology.

Source link: https://doi.org/10.1371/journal.pone.0266189


MicroRNA-21 induces cisplatin resistance in head and neck squamous cell carcinoma

For miR-21 detection, matched tissue samples from 30 head and neck squamous cell carcinoma patients and 8 head and neck cancer cell lines were obtained. MiR-21 expression in 25 cancer tissues was found in the 30 matched pair tissues, and in the corresponding normal control tissues, was similarly reduced in three cases: UPCI-4B, UMSCC-1, and UPCI-15B. The miR-21 mimic enhanced cell proliferation with reduced apoptosis and improved viability in both the UMSCC-1 and UPCI-4B cell lines, whereas the miR-21 inhibitor caused the opposite effect; in addition, miR-21 specifically targeted the tumour suppressor phosphatase and tensin homologue and blocked PTEN expression; additionally, miR-21 inhibitor inhibited PTEN expression. miR-21 overexpression can promote cell proliferation, reduce apoptosis, and instill drug resistance by inhibiting PTEN expression. Targeting miR-21 can aid in cancer diagnosis, improve drug tolerance, and boost therapeutic effects.

Source link: https://doi.org/10.1371/journal.pone.0267017


Detection of SARS-CoV-2 infection by microRNA profiling of the upper respiratory tract

Host biomarkers are increasingly being considered as tools for enhanced COVID-19 detection and prognosis. A three-miRNA signature reliably classified COVID-19 cases with 100 percent certainty, according to a semi-miRNA fingerprint that independently assesses COVID-19 cases with 100 percent accuracy. This research expands the host miRNA response to SARS-CoV-2 disease and identifies potential biomarkers for improved COVID-19 detection.

Source link: https://doi.org/10.1371/journal.pone.0265670


Nuclear microRNA-466c regulates Vegfa expression in response to hypoxia

We'll show here that nuclear microRNA miR-466c participates in the regulation of vascular endothelial growth factor a gene expression in hypoxia. Long non-coding RNA on mouse Vegfa promoter is shown by miR-466c, which can be linked to this transcript in order to change Vegfa expression. These findings reveal that miR-466c controls gene transcription in the nucleus by targeting the promoter, as well as expanding our knowledge of miRNAs well beyond their canonical role.

Source link: https://doi.org/10.1371/journal.pone.0265948

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions